Multipartite structure of a negative regulatory element associated with a steroid hormone-inducible promoter.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

[36] Eukaryotic gene transcription with purified components

1983 • 992 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

1983 • 619 citations

Multiple sequence motifs are involved in SV40 enhancer function.

1986 • 511 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

1986 • 406 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression.

1984 • 375 citations

Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters

1985 • 366 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

The SV40 enhancer contains two distinct levels of organization

1988 • 286 citations

Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action

1975 • 284 citations

The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.

1987 • 275 citations

The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificity.

1987 • 265 citations

Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription

1989 • 265 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.

1984 • 247 citations

Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

1983 • 238 citations

Promoter specificity and modulation of RNA polymerase II transcription

1989 • 221 citations

A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.

1983 • 213 citations

A control element within a structural gene: The gal operon of Escherichia coli

1983 • 206 citations

The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of replication, and the BK virus enhancer

1985 • 203 citations

Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates.

1984 • 202 citations

Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P₁450 gene

1985 • 174 citations

Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus.

1987 • 168 citations

Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.

1985 • 164 citations

Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumour virus DNA.

1982 • 153 citations

Purified glucocorticoid receptor-hormone complex from rat liver cytosol binds specifically to cloned mouse mammary tumor virus long terminal repeats in vitro.

1982 • 147 citations

The 5′ region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element.

1985 • 146 citations

A negative transcriptional control element located upstream of the murine c-myc gene.

1986 • 142 citations

Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene.

1986 • 113 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

Functional analysis of the steroid hormone control region of mouse mammary tumor virus

1984 • 84 citations

Mouse mammary tumor virus proviruses in T-cell lymphomas lack a negative regulatory element in the long terminal repeat

1988 • 82 citations

Alterations in the U3 region of the long terminal repeat of an infectious thymotropic type B retrovirus

1988 • 80 citations

Transcriptional repression of a hormone-responsive promoter

1987 • 77 citations

Modulation of enhancer activity by the hormone responsive regulatory element from mouse mammary tumor virus.

1984 • 74 citations

Functional elements of the steroid hormone-responsive promoter of mouse mammary tumor virus

1990 • 71 citations

Binding of multiple factors to the MMTV promoter in crude and fractionated nuclear extracts

1988 • 68 citations

Negative regulation of transcription in vitro by a glucocorticoid response element is mediated by a trans-acting factor.

1988 • 67 citations

Rearrangements in the long terminal repeat of extra mouse mammary tumor proviruses in T-cell leukemias of mouse strain GR result in a novel enhancer-like structure.

1985 • 65 citations

A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter.

1989 • 65 citations

Tandemly Reiterated Negative Enhancer-like Elements Regulate Transcription of a Human Gene for the Large Subunit of Calcium-dependent Protease

1989 • 60 citations

The S promoter of hepatitis B virus is regulated by positive and negative elements.

1988 • 53 citations

The chicken ovalbumin promoter is under negative control which is relieved by steroid hormones.

1987 • 52 citations

Context-Dependent Gene Expression: cis-Acting Negative Effects of Specific Procaryotic Plasmid Sequences on Eucaryotic Genes

1987 • 42 citations

Multiple Hormone-Inducible Enhancers as Mediators of Differential Transcription

1986 • 29 citations

A transcriptionally defective long terminal repeat within an endogenous copy of mouse mammary tumor virus proviral DNA

1988 • 28 citations

Multiple protein binding sites within the ovalbumin gene 5′-flanking region: isolation and characterization of sequence-specific binding proteins

1989 • 18 citations

Amplification of mouse mammary tumor virus genomes in non-mammary tumor cells

1989 • 13 citations