Transcriptional repression of a hormone-responsive promoter

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment

1984 • 898 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences

1981 • 657 citations

Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

1981 • 624 citations

The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

1983 • 619 citations

Deletion of thymidine kinase activity from L cells resistant to bromodeoxyuridine

1963 • 611 citations

Enhancer elements

1983 • 576 citations

Characterization of a “silencer” in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer

1985 • 531 citations

Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids

1981 • 489 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

Specific interaction between enhancer-containing molecules and cellular components

1984 • 374 citations

A repressor (MATα2 product) and its operator control expression of a set of cell type specific genes in yeast

1985 • 368 citations

Purified glucocorticoid receptors bind selectively in vitro to a cloned DNA fragment whose transcription is regulated by glucocorticoids in vivo.

1981 • 341 citations

Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action

1975 • 284 citations

Control of Cytochrome P ₁ -450 Gene Expression by Dioxin

1985 • 272 citations

Immunoglobulin Heavy-Chain Enhancer Requires One or More Tissue-Specific Factors

1985 • 271 citations

A novel transcription property of SP6 and T7 RNA polymerases: dependence on template structure

1985 • 267 citations

Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus

1981 • 261 citations

Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.

1977 • 256 citations

Role of DNA replication in the repression of silent mating type loci in yeast

1984 • 254 citations

THE REGULATION OF TRANSCRIPTION INITIATION IN BACTERIA

1985 • 251 citations

Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus.

1984 • 247 citations

Cloning vectors that yield high levels of single-stranded DNA for rapid DNA sequencing

1984 • 238 citations

Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

1983 • 238 citations

A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene

1984 • 237 citations

A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.

1983 • 213 citations

Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates.

1984 • 202 citations

A trans-acting factor is responsible for the simian virus 40 enhancer activity in vitro

1985 • 196 citations

Detection of factors that interact with the human β-interferon regulatory region in vivo by DNAase I footprinting

1986 • 188 citations

Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P₁450 gene

1985 • 174 citations

Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.

1985 • 164 citations

Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumour virus DNA.

1982 • 153 citations

Purified glucocorticoid receptor-hormone complex from rat liver cytosol binds specifically to cloned mouse mammary tumor virus long terminal repeats in vitro.

1982 • 147 citations

The 5′ region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element.

1985 • 146 citations

A negative transcriptional control element located upstream of the murine c-myc gene.

1986 • 142 citations

Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene.

1986 • 113 citations

Chromosomal position effects determine transcriptional potential of integrated mammary tumor virus DNA

1982 • 101 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

Functional analysis of the steroid hormone control region of mouse mammary tumor virus

1984 • 84 citations

Modulation of enhancer activity by the hormone responsive regulatory element from mouse mammary tumor virus.

1984 • 74 citations

Glucocorticoids and Chromosomal Position Modulate Murine Mammary Tumor Virus Transcription by Affecting Efficiency of Promoter Utilization

1983 • 71 citations

Rearrangements in the long terminal repeat of extra mouse mammary tumor proviruses in T-cell leukemias of mouse strain GR result in a novel enhancer-like structure.

1985 • 65 citations

Repression of transcription in yeast

1985 • 59 citations

Generation of glucocorticoid-responsive Moloney murine leukemia virus by insertion of regulatory sequences from murine mammary tumor virus into the long terminal repeat

1985 • 56 citations

Exogenous mouse mammary tumor virus proviral DNA isolated from a kidney adenocarcinoma cell line contains alterations in the U3 region of the long terminal repeat

1986 • 50 citations

Context-Dependent Gene Expression: cis-Acting Negative Effects of Specific Procaryotic Plasmid Sequences on Eucaryotic Genes

1987 • 42 citations

Sequence organization and molecular cloning of mouse mammary tumor virus DNA endogenous to C57BL/6 mice

1985 • 34 citations

Multiple Hormone-Inducible Enhancers as Mediators of Differential Transcription

1986 • 29 citations

Alterations in chromatin structure associated with glucocorticoid-induced expression of endogenous mouse mammary tumor virus genes.

1985 • 20 citations

Alterations in Chromatin Structure Associated with Glucocorticoid-Induced Expression of Endogenous Mouse Mammary Tumor Virus Genes

1985 • 8 citations