The α Chain of the T Cell Antigen Receptor Is Degraded in the Cytosol

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components.

1975 • 1,175 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Common Principles of Protein Translocation Across Membranes

1996 • 1,081 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

Use of a Monoclonal Antibody (W6/32) in Structural Studies of HLA-A,B,C Antigens

1979 • 682 citations

[6] Preparation of microsomal membranes for cotranslational protein translocation

1983 • 679 citations

Quality control in the secretory pathway

1995 • 679 citations

PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

1996 • 560 citations

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

1986 • 547 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

1996 • 451 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1996 • 400 citations

The T Cell Antigen Receptor: Insights into Organelle Biology

1990 • 361 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

1992 • 286 citations

[4] Enzymatic deglycosylation of asparagine-linked glycans: Purification, properties, and specificity of oligosaccharide-cleaving enzymes from Flavobacterium meningosepticum

1994 • 284 citations

Identification of a tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen

1994 • 275 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

1990 • 266 citations

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.

1989 • 228 citations

Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β₂‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

1988 • 224 citations

A Peptide Sequence Confers Retention and Rapid Degradation in the Endoplasmic Reticulum

1990 • 219 citations

Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum.

1991 • 215 citations

A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface

1997 • 202 citations

Degradation of proteins within the endoplasmic reticulum

1991 • 191 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

Purification and enzymatic properties of peptide:N-glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrence of post-translational remodification of proteins by N-deglycosylation

1994 • 141 citations

Major histocompatibility complex independent clonal T cell anergy by direct interaction of Staphylococcus aureus enterotoxin B with the T cell antigen receptor.

1992 • 140 citations

Selective degradation of T cell antigen receptor chains retained in a pre-Golgi compartment.

1988 • 139 citations

Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment.

1995 • 129 citations

The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes.

1995 • 115 citations

A role for a pre-T-cell receptor in T-cell development

1993 • 114 citations

Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of “ER-resident” molecular chaperones

1997 • 108 citations

Depletion of cellular calcium accelerates protein degradation in the endoplasmic reticulum

1991 • 105 citations

Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis

1996 • 104 citations

Requirements for cell surface expression of the human TCR/CD3 complex in non-T cells

1991 • 92 citations

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

1994 • 87 citations

The gamma and epsilon subunits of the CD3 complex inhibit pre-Golgi degradation of newly synthesized T cell antigen receptors.

1990 • 81 citations

Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

1994 • 76 citations

Translocation of TCRα Chains into the Lumen of the Endoplasmic Reticulum and Their Degradation

1993 • 75 citations

Intermediates in the Assembly and Degradation of Class I Major Histocompatibility Complex (MHC) Molecules Probed with Free Heavy Chain–specific Monoclonal Antibodies

1996 • 49 citations

Associations between subunit ectodomains promote T cell antigen receptor assembly and protect against degradation in the ER

1993 • 46 citations

One‐Dimensional Isoelectric Focusing of Proteins in Slab Gels

1995 • 39 citations

The T‐Cell Antigen Receptor

1988 • 39 citations

Production and characterization of antibody probes directed at constant regions of the α and β subunit of the human T cell receptor

1985 • 28 citations

Two‐Dimensional Gel Electrophoresis

1998 • 19 citations

[21] Immunotitration of 3-hydroxy-3-methylglutaryl-CoA reductase

1981 • 5 citations