Protein Transport from the Cytoplasm into the Vacuole

Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae

1993 • 1,649 citations

Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction.

1992 • 1,187 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

1996 • 904 citations

The fungal vacuole: composition, function, and biogenesis

1990 • 758 citations

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1990 • 674 citations

Implications of the SNARE hypothesis for intracellular membrane topology and dynamics

1994 • 582 citations

Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

1994 • 544 citations

Autophagy and related mechanisms of lysosome-mediated protein degradation

1994 • 506 citations

Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway.

1995 • 493 citations

Ultrastructural analysis of the autophagic process in yeast: detection of autophagosomes and their characterization

1994 • 480 citations

Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae

1997 • 466 citations

Autophagy and other vacuolar protein degradation mechanisms

1992 • 408 citations

Proteasomes: destruction as a programme

1996 • 373 citations

Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway.

1992 • 371 citations

Novel System for Monitoring Autophagy in the Yeast Saccharomyces cerevisiae

1995 • 344 citations

Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

1996 • 259 citations

Genetic and Phenotypic Overlap between Autophagy and the Cytoplasm to Vacuole Protein Targeting Pathway

1996 • 257 citations

Peptide sequences that target proteins for enhanced degradation during serum withdrawal.

1988 • 238 citations

Lysosomal (Vacuolar) Proteinases of Yeast Are Essential Catalysts for Protein Degradation, Differentiation, and Cell Survival

1989 • 230 citations

Three proteolytic systems in the yeast saccharomyces cerevisiae

1991 • 228 citations

Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris

1995 • 218 citations

Protein and peptide binding and stimulation of in vitro lysosomal proteolysis by the 73-kDa heat shock cognate protein.

1992 • 201 citations

Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes

1983 • 189 citations

Review: Biosynthesis and function of yeast vacuolar proteases

1996 • 184 citations

Regulated import and degradation of a cytosolic protein in the yeast vacuole

1991 • 174 citations

Turnover of Yeast Fructose-Bisphosphatase in Different Metabolic Conditions

1980 • 147 citations

Transport of a Large Oligomeric Protein by the Cytoplasm to Vacuole Protein Targeting Pathway

1997 • 146 citations

Analysis of the Membrane Structures Involved in Autophagy in Yeast by Freeze-Replica Method.

1995 • 145 citations

Acidification of Vacuoles Is Required for Autophagic Degradation in the Yeast, Saccharomyces cerevisiae

1997 • 133 citations

A novel pathway of import of alpha-mannosidase, a marker enzyme of vacuolar membrane, in Saccharomyces cerevisiae.

1990 • 125 citations

SNAREs and the specificity of transport vesicle targeting

1995 • 123 citations

Selective autophagy of peroxisomes in methylotrophic yeasts.

1993 • 121 citations

Catabolite Inactivation of Fructose-1,6-bisphosphatase of Saccharomyces cerevisiae

1995 • 116 citations

Isolation and characterization of mutants impaired in the selective degradation of peroxisomes in the yeast Hansenula polymorpha

1995 • 113 citations

Selective Uptake of Cytosolic, Peroxisomal, and Plasma Membrane Proteins into the Yeast Lysosome for Degradation

1996 • 104 citations

Polypeptide import and degradation by isolated lysosomes.

1993 • 103 citations

Structural and functional analyses of APG5 a gene involved in autophagy in yeast

1996 • 103 citations

Stress‐induced proteolysis in yeast

1992 • 103 citations

Cloning and heterologous expression of glycosidase genes from Saccharomyces cerevisiae.

1987 • 103 citations

Nucleotide sequence ofAMS1, the structure gene of vacuolarα-mannosidase of Saccharomyces cerevisiae

1989 • 102 citations

Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.

1996 • 102 citations

AUT1, a gene essential for autophagocytosis in the yeast Saccharomyces cerevisiae

1997 • 97 citations

Identification of Novel Vesicles in the Cytosol to Vacuole Protein Degradation Pathway

1997 • 97 citations

Isolation of Degradation-Deficient Mutants Defective in the Targeting of Fructose-1,6-bisphosphatase into the Vacuole for Degradation in Saccharomyces cerevisiae

1996 • 88 citations

Structure and function of the yeast vacuolar membrane proton ATPase

1989 • 79 citations

Catabolite inactivation of fructose‐1,6‐bisphosphatase in yeast is mediated by the proteasome

1994 • 77 citations

Molecular Cloning and Sequencing of Genomic DNA Encoding Aminopeptidase I from Saccharomyces cerevisiae

1989 • 68 citations

Degradation of microbodies in relation of activities of alcohol oxidase and catalase inCandida boidinii

1978 • 65 citations

Yeast vacuolar aminopeptidase yscI

1989 • 59 citations

Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae.

1988 • 58 citations

Yeast aminopeptidase I is post-translationally sorted from the cytosol to the vacuole by a mechanism mediated by its bipartite N-terminal extension.

1995 • 44 citations

Hsp70s and lysosomal proteolysis

1994 • 43 citations

In vitro reconstitution of cytoplasm to vacuole protein targeting in yeast.

1995 • 40 citations

Selective inactivation of alcohol oxidase in two peroxisome‐deficient mutants of the yeast Hansenula polymorpha

1991 • 38 citations

Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non‐selective proteolysis, the vacuole

1992 • 36 citations

Biogenesis and turnover of peroxisomes involved in the concurrent oxidation of methanol and methylamine in Hansenula polymorpha

1981 • 35 citations

Degradation of peroxisomes after transfer of methanol-grown Hansenula polymorpha into glucose-containing media

1978 • 33 citations

Autophagic death after cell cycle arrest at the restrictive temperature in temperature-sensitive cell division cycle and secretory mutants of the yeast Saccharomyces cerevisiae.

1995 • 25 citations

Catabolite inactivation of fructose 1,6-bisphosphatase and cytoplasmic malate dehydrogenase in yeast

1985 • 22 citations

Degradative inactivation of the peroxisomal enzyme, alcohol oxidase, during adaptation of methanol-grown Candida boidinii to ethanol

1985 • 21 citations

Site of catabolite inactivation

1994 • 18 citations

Evidence for non-vacuolar proteolytic catabolite inactivation of yeast fructose-1,6-bisphosphatase

1987 • 17 citations