Smad3 Mediates Transforming Growth Factor-β-induced Collagenase-3 (Matrix Metalloproteinase-13) Expression in Human Gingival Fibroblasts

How Matrix Metalloproteinases Regulate Cell Behavior

2001 • 3,860 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Transforming Growth Factor-β Signaling Through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation

2002 • 622 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Smads as transcriptional co-modulators

2000 • 522 citations

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1997 • 470 citations

Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-β

2000 • 389 citations

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1999 • 388 citations

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1997 • 383 citations

Matrix metalloproteinases in tumor invasion

2000 • 344 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

Smads bind directly to the Jun family of AP-1 transcription factors

1999 • 324 citations

Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development

1997 • 292 citations

Smad2 transduces common signals from receptor serine–threonine and tyrosine kinases

1998 • 291 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-β-induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells

2001 • 276 citations

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 • 261 citations

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4

1999 • 249 citations

Transforming Growth Factor-β Repression of Matrix Metalloproteinase-1 in Dermal Fibroblasts Involves Smad3

2001 • 247 citations

Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase

2000 • 247 citations

Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells.

1988 • 244 citations

Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.

1997 • 235 citations

Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector

1992 • 222 citations

Transforming Growth Factor-β Induces Collagenase-3 Expression by Human Gingival Fibroblasts via p38 Mitogen-activated Protein Kinase

1999 • 214 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Activation of p38α MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization

2002 • 211 citations

Structural Analysis and Promoter Characterization of the Human Collagenase-3 Gene (MMP13)

1997 • 198 citations

Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts

2001 • 187 citations

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene ( COL 7A1 ) promoter by transforming growth factor β

1998 • 178 citations

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

1999 • 171 citations

Smad3 and Smad4 Mediate Transcriptional Activation of the Human Smad7 Promoter by Transforming Growth Factor β

2000 • 167 citations

Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3

2000 • 167 citations

Inactivation of Smad-Transforming Growth Factor β Signaling by Ca²⁺-Calmodulin-Dependent Protein Kinase II

2000 • 161 citations

Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase

1997 • 160 citations

Cell-specific Induction of Distinct Oncogenes of the Jun Family Is Responsible for Differential Regulation of Collagenase Gene Expression by Transforming Growth Factor-β in Fibroblasts and Keratinocytes

1996 • 157 citations

Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins

1999 • 155 citations

Participation of Smad2, Smad3, and Smad4 in Transforming Growth Factor β (TGF-β)-induced Activation of Smad7

2000 • 137 citations

Cross-talk between the p42/p44 MAP Kinase and Smad Pathways in Transforming Growth Factor β1-induced Furin Gene Transactivation

2001 • 124 citations

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

1999 • 120 citations

Smad-dependent Transcriptional Activation of Human Type VII Collagen Gene (COL7A1) Promoter by Transforming Growth Factor-β

1998 • 118 citations

Role of p38 MAPK in Transforming Growth Factor β Stimulation of Collagen Production by Scleroderma and Healthy Dermal Fibroblasts

2002 • 111 citations

Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity

2000 • 105 citations

Regulation of Clusterin Gene Expression by Transforming Growth Factor β

1997 • 98 citations

Human proα1(I) collagen: cDNA sequence for the C-propeptide domain

1988 • 86 citations

Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.

1997 • 83 citations

Expression of transforming-growth-factor (TGF)-? receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-?1

1999 • 77 citations

Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase.

2001 • 72 citations

Expression of collagenase‐3 (MMP‐13) enhances invasion of human fibrosarcoma HT‐1080 cells

2001 • 55 citations

Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites.

2001 • 42 citations

Smad3 Inhibits Transforming Growth Factor-β and Activin Signaling by Competing with Smad4 for FAST-2 Binding

1999 • 38 citations

Transcriptional targeting of adenoviral gene delivery into migrating wound keratinocytes using FiRE, a growth factor-inducible regulatory element

2000 • 18 citations