Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-β-induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

In VitroChondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells

1998 • 2,347 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

1999 • 841 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

SOX9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Up-regulated by Retinoic Acid in a Cartilage-derived Cell Line, TC6

2000 • 469 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

1999 • 441 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation

1999 • 419 citations

A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells

1990 • 384 citations

FGF-4 and BMP-2 have opposite effects on limb growth

1993 • 377 citations

Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vitro: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor.

1996 • 376 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Insulin signal transduction through protein kinase cascades.

1998 • 364 citations

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

1999 • 347 citations

Chondrocyte Differentiation

1995 • 330 citations

Roles of Aggrecan, a Large Chondroitin Sulfate Proteoglycan, in Cartilage Structure and Function

1998 • 314 citations

Smad2 transduces common signals from receptor serine–threonine and tyrosine kinases

1998 • 291 citations

Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene

1998 • 288 citations

p38 Mitogen-activated Protein Kinase-dependent and -independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils

1998 • 282 citations

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

1999 • 265 citations

Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: I. Stimulation by bone morphogenetic protein-2 in high-density micromass cultures

1999 • 253 citations

Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene

1994 • 242 citations

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

1997 • 220 citations

A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH₂-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5

1999 • 212 citations

Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-β1

1995 • 205 citations

p38 Mitogen-Activated Protein Kinase Functionally Contributes to Chondrogenesis Induced by Growth/Differentiation Factor-5 in ATDC5 Cells

1999 • 203 citations

The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain

2000 • 177 citations

Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

1997 • 175 citations

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

1999 • 171 citations

Glucocorticoid receptor inhibits transforming growth factor-β signaling by directly targeting the transcriptional activation function of Smad3

1999 • 169 citations

Sequential Progression of the Differentiation Program by Bone Morphogenetic Protein-2 in Chondrogenic Cell Line ATDC5

1998 • 155 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

1998 • 139 citations

Altered Transforming Growth Factor β Signaling in Epithelial Cells when Ras Activation Is Blocked

1996 • 128 citations

Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

1999 • 120 citations

Continuously growing bipotential and monopotential myogenic, adipogenic, and chondrogenic subclones isolated from the multipotential RCJ 3.1 clonal cell line

1990 • 111 citations

Controlled conversion of an immortalized mesodermal progenitor cell towards osteogenic, chondrogenic, or adipogenic pathways.

1995 • 99 citations

Genetics of skeletogenesis

1998 • 93 citations

Bone growth: Coordinating chondrocyte differentiation

1996 • 79 citations

Insulin-Like Growth Factors I and II Are Autocrine Factors in Stimulating Proteoglycan Synthesis, a Marker of Differentiated Chondrocytes, Acting through Their Respective Receptors on a Clonal Human Chondrosarcoma-Derived Chondrocyte Cell Line, HCS-2/8¹

1997 • 77 citations

Transforming Growth Factor-β1 Stimulates Protein Kinase A in Mesangial Cells

1998 • 77 citations

Regulation of expression of the chondrocytic phenotype in a skeletal cell line (CFK2) in vitro

1993 • 65 citations

Overexpression of a Single Helix-Loop-Helix-type Transcription Factor, Scleraxis, Enhances Aggrecan Gene Expression in Osteoblastic Osteosarcoma ROS17/2.8 Cells

1997 • 65 citations

Differential effects of transforming growth factors beta 1, beta 2, beta 3 and beta 5 on chondrogenesis in mouse limb bud mesenchymal cells.

1997 • 55 citations

Distinct spatial and temporal distributions of aggrecan and versican in the embryonic chick heart

1999 • 54 citations

Analysis of chondroprogenitor frequency and cartilage differentiation in a novel family of clonal chondrogenic rat cell lines

1996 • 52 citations

Distinct spatial and temporal distributions of aggrecan and versican in the embryonic chick heart

1999 • 48 citations