c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A

1975 • 3,054 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 • 1,028 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

1982 • 494 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Avian leukemia viruses interaction with their target cells in vivo and in vitro

1978 • 421 citations

v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis

1986 • 244 citations

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

1986 • 235 citations

BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines

1983 • 224 citations

Neoplastic Transformation of Human Epidermal Keratinocytes by AD12-SV40 and Kirsten Sarcoma Viruses

1985 • 223 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

1985 • 210 citations

Primary Rat Embryo Cells Transformed by One or Two Oncogenes Show Different Metastatic Potentials

1986 • 196 citations

Induction of human cervical squamous cell carcinoma by sequential transfection with human papillomavirus 16 DNA and viral Harvey ras.

1989 • 177 citations

Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones

1989 • 164 citations

Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy.

1987 • 159 citations

Genetic suppression of tumor formation: a new frontier in cancer research.

1986 • 152 citations

Resistance of human cells to tumorigenesis induced by cloned transforming genes.

1983 • 147 citations

Growth and Differentiation Characteristics of Transformed Keratinocytes from Mouse and Human Skin in Vitro and in Vivo

1983 • 127 citations

Selective transfer of individual human chromosomes to recipient cells.

1985 • 118 citations

Suppression of tumor growth by senescence in virally transformed human fibroblasts.

1986 • 108 citations

Mouse epidermal cell cultures

1975 • 107 citations

Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells.

1986 • 94 citations

Differentiation specific functions in cultured and transplanted mouse keratinocytes:

1984 • 91 citations

Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral harvey ras

1988 • 81 citations

Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation.

1988 • 76 citations

Environmental modulation of the expression of differentiation and malignancy in six human squamous cell carcinoma cell lines.

1985 • 74 citations

Response modification creates promotability in multistage carcinogenesis

1988 • 74 citations

Block in the expression of differentiation markers of rat thyroid epithelial cells by transformation with Kirsten murine sarcoma virus.

1982 • 74 citations

Evidence for multiple steps in neoplastic transformation of normal and preneoplastic Syrian hamster embryo cells following transfection with Harvey murine sarcoma virus oncogene (v-Ha-ras).

1985 • 60 citations

Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the Kirsten murine sarcoma virus.

1983 • 57 citations

Morphological transformation, focus formation, and anchorage independence induced in diploid human fibroblasts by expression of a transfected H-ras oncogene.

1987 • 55 citations

Transfection of the EJ ras^Ha Gene into Keratinocytes Derived from Carcinogen-Induced Mouse Papillomas Causes Malignant Progression

1986 • 47 citations

Oncogene activation in malignant transformation: a study of H-ras in human breast cancer.

1987 • 45 citations

Mammalian Epidermal Cells in Culture

1986 • 44 citations

Multi-step neoplastic transformation of normal human fibroblasts by Co-60 gamma rays and Ha-ras oncogenes

1988 • 42 citations

Phenotypic and cytogenetic characteristics of different stages during spontaneous transformation of mouse keratinocytes in vitro.

1985 • 40 citations

Environmental induction of differentiation-specific keratins in malignant mouse keratinocyte lines.

1986 • 38 citations

Transformation of primary human embryonic kidney cells to anchorage independence by a combination of BK virus DNA and the Harvey-ras oncogene

1986 • 33 citations

Normal human mesothelial cells and fibroblasts transfected with the EJras oncogene become EGF-independent, but are not malignantly transformed.

1987 • 33 citations

Suppression of tumorigenicity in human cell hybrids derived from cell lines expressing different activated ras oncogenes.

1989 • 24 citations

Site-Specific Integration of H- ras in Transformed Rat Embryo Cells

1988 • 23 citations

Effect of cellular determination on oncogenic transformation by chemicals and oncogenes.

1988 • 18 citations

Initial studies on cultured embryonic chick lens epithelial cells infected with a temperature-sensitive Rous sarcoma virus

1981 • 18 citations