Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK)

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Taxol: A Unique Antineoplastic Agent with Significant Activity in Advanced Ovarian Epithelial Neoplasms

1989 • 1,111 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

THE IMPACT OF NATIONAL CANCER ACT

1991 • 809 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer

1991 • 730 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis.

1996 • 352 citations

Shared Actions of Endotoxin and Taxol on TNF Receptors and TNF release

1990 • 288 citations

Taxanes: A New Class of Antitumor Agents

1995 • 276 citations

Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates

1998 • 239 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

1994 • 185 citations

Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages.

1992 • 180 citations

Interaction between c-Rel and the Mitogen-activated Protein Kinase Kinase Kinase 1 Signaling Cascade in Mediating B Enhancer Activation

1996 • 166 citations

Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor α and interleukin-1 in macrophages

1992 • 153 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

Taxol provides a second signal for murine macrophage tumoricidal activity.

1994 • 138 citations

Constitutive production of macrophage colony-stimulating factor by human ovarian and breast cancer cell lines.

1989 • 135 citations

Major Histocompatibility Complex Class II-associated Invariant Chain Gene Expression Is Up-regulated by Cooperative Interactions of Sp1 and NF-Y

1995 • 129 citations

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

1998 • 122 citations

Tumor Necrosis Factor (TNF) Receptor 1 Signaling Downstream of TNF Receptor-associated Factor 2

1997 • 117 citations

Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.

1996 • 110 citations

Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa B site.

1994 • 108 citations

Lipopolysaccharide antagonists block taxol-induced signaling in murine macrophages.

1993 • 103 citations

Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants

1997 • 98 citations

Transient stimulation of the c-Jun-NH2-terminal kinase/activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts.

1998 • 90 citations

Identification of Tumor-Specific Paclitaxel (Taxol)-Responsive Regulatory Elements in the Interleukin-8 Promoter

1997 • 90 citations

Taxol-dependent transcriptional activation of IL-8 expression in a subset of human ovarian cancer.

1996 • 88 citations

Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells

1998 • 69 citations

Paclitaxel (Taxol(R)) inhibits motility of paclitaxel-resistant human ovarian carcinoma cells.

1996 • 64 citations

Use of paclitaxel (Taxol) in squamous cell carcinoma of the head and neck.

1993 • 61 citations

Apoptosis during HL‐60 cell differentiation is closely related to a G0/G1 cell cycle arrest

1995 • 57 citations

Preferential Involvement of MEK1 in the Tumor Necrosis Factor-α-induced Activation of p42mapk/erk2 in Mouse Macrophages

1995 • 49 citations

Taxol enhances but does not induce interleukin-1 beta and tumor necrosis factor-alpha production.

1993 • 42 citations

Ovarian cancer cell invasion is inhibited by paclitaxel.

1997 • 38 citations

Identification of the structural region of taxol that may be responsible for cytokine gene induction and cytotoxicity in human ovarian cancer cells

1998 • 21 citations

Docetaxel (Taxotere) in the treatment of solid tumors other than breast and lung cancer.

1995 • 18 citations

Affinity Enrichment and Functional Characterization of TRAX1, a Novel Transcription Activator and X1-Sequence-Binding Protein of HLA-DRA

1995 • 10 citations

Effects of Combined Chemotherapy on Sarcoma 180, With Special Reference to Food Intake, Body-Weight Changes, and Survival Time<xref ref-type="fn" rid="fn1">2</xref>

1954 • 5 citations