RhoGDI: multiple functions in the regulation of Rho family GTPase activities

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho GTPases in cell biology

2002 • 4,662 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

ERM proteins and merlin: integrators at the cell cortex

2002 • 1,301 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Differential Localization of Rho Gtpases in Live Cells

2001 • 686 citations

The Phagosome Proteome

2001 • 680 citations

Rho GTPase-activating proteins in cell regulation

2002 • 608 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Integrins Regulate Rac Targeting by Internalization of Membrane Domains

2004 • 533 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

2000 • 494 citations

Rho Guanine Dissociation Inhibitors

1999 • 487 citations

Targeting Rab GTPases to distinct membrane compartments

2004 • 464 citations

Inhibition of RhoA by p120 catenin

2000 • 459 citations

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

2003 • 456 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

2004 • 362 citations

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

2002 • 326 citations

Serine Phosphorylation Negatively Regulates RhoA in Vivo

2003 • 307 citations

Protein Kinase C-α Signals Rho-Guanine Nucleotide Dissociation Inhibitor Phosphorylation and Rho Activation and Regulates the Endothelial Cell Barrier Function

2001 • 253 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: an essential role for polyphosphoinositides in vivo

2002 • 240 citations

Phosphorylation of RhoGDI by Pak1 Mediates Dissociation of Rac GTPase

2004 • 233 citations

Cytoskeletal regulation: rich in lipids

2004 • 220 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα

1999 • 205 citations

The Rho Small G Protein Family-Rho GDI System as a Temporal and Spatial Determinant for Cytoskeletal Control

1998 • 200 citations

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.

2000 • 198 citations

Calcium Signaling Regulates Translocation and Activation of Rac

2003 • 195 citations

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

1997 • 169 citations

Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

2002 • 163 citations

Always look on the bright site of Rho: structural implications for a conserved intermolecular interface

2004 • 151 citations

Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

2003 • 147 citations

Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex

1998 • 147 citations

Crystal Structure of the Rac1−RhoGDI Complex Involved in NADPH Oxidase Activation^,

2001 • 135 citations

Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

2002 • 131 citations

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

1997 • 118 citations

A novel role for RhoGDI as an inhibitor of GAP proteins.

1993 • 117 citations

RhoGDI-3 Is a New GDP Dissociation Inhibitor (GDI)

1996 • 117 citations

Stimulation of phospholipase C-β₂by the Rho GTPases Cdc42Hs and Rac1

1998 • 117 citations

The δ Subunit of Retinal Rod cGMP Phosphodiesterase Regulates the Membrane Association of Ras and Rap GTPases

2002 • 114 citations

Epidermal Growth Factor-dependent Regulation of Cdc42 Is Mediated by the Src Tyrosine Kinase

2003 • 111 citations

RhoGDIγ: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

1997 • 102 citations

Localization of AtROP4 and AtROP6 and interaction with the guanine nucleotide dissociation inhibitor AtRhoGDI1 from Arabidopsis.

2000 • 94 citations

Mechanism of NADPH Oxidase Activation by the Rac/Rho-GDI Complex

2001 • 92 citations

Molecular cloning and characterization of yeast rho GDP dissociation inhibitor.

1994 • 86 citations

RhoGDI Is Required for Cdc42-Mediated Cellular Transformation

2003 • 84 citations

Dissociation of GDP Dissociation Inhibitor and Membrane Translocation Are Required for Efficient Activation of Rac by the Dbl Homology-Pleckstrin Homology Region of Tiam

2003 • 76 citations

How RhoGDI binds Rho

1999 • 76 citations

Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae

1997 • 73 citations

Phosphoinositide‐dependent activation of Rho A involves partial opening of the RhoA/Rho‐GDI complex

1999 • 73 citations

Vav1 and Ly-GDI Two Regulators of Rho GTPases, Function Cooperatively as Signal Transducers in T Cell Antigen Receptor-induced Pathways

2002 • 70 citations

Residues of the Rho Family GTPases Rho and Cdc42 That Specify Sensitivity to Dbl-like Guanine Nucleotide Exchange Factors

1997 • 68 citations

Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity

1998 • 65 citations

Defects in cytokinesis, actin reorganization and the contractile vacuole in cells deficient in RhoGDI

2002 • 64 citations

Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)

2001 • 64 citations

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI

2001 • 64 citations

Kinetics of Cdc42 Membrane Extraction by Rho-GDI Monitored by Real-Time Fluorescence Resonance Energy Transfer

1999 • 63 citations

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

2002 • 63 citations

Selective Activation of Small GTPase RhoA by Tyrosine Kinase Etk through Its Pleckstrin Homology Domain

2002 • 61 citations

Phagocytosis, an alternative model system for the study of cell adhesion

2004 • 60 citations

Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.

1996 • 58 citations

A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors.

1995 • 54 citations

RhoGDI‐3 Regulates RhoG and Targets This Protein to the Golgi Complex Through its Unique N‐Terminal Domain

2002 • 53 citations

Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases

1997 • 42 citations

Global Effects of BCR/ABL and TEL/PDGFRβ Expression on the Proteome and Phosphoproteome

2004 • 41 citations

Phagocytosis, an alternative model system for the study of cell adhesion

2004 • 40 citations

An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells

2004 • 37 citations

RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells

2001 • 34 citations

Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation

1996 • 34 citations

LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane

2004 • 34 citations

Phosphorylation of Rho GDI Stabilizes the Rho A-Rho GDI Complex in Neutrophil Cytosol

1996 • 31 citations

RhoGDI-binding-defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells

2001 • 29 citations

Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex

2001 • 28 citations

Rapid association of cytoskeletal remodeling proteins with the developing phagosomes of human neutrophils

2002 • 21 citations

An activating mutant of Cdc42 that fails to interact with Rho GDP-dissociation inhibitor localizes to the plasma membrane and mediates actin reorganization

2004 • 20 citations

A Rho GDP-dissociation inhibitor is involved in cytokinesis of Dictyostelium

2002 • 15 citations

Structural consequences of site‐directed mutagenesis in flexible protein domains

2001 • 11 citations

Molecular characterization of the Caenorhabditis elegans Rho GDP‐dissociation inhibitor

1999 • 8 citations