Reversible lymphomagenesis in conditionally c‐MYC expressing mice

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

A matter of life and death

2002 • 1,251 citations

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors

1994 • 1,047 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

2002 • 845 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

Translocations Among Antibody Genes in Human Cancer

1983 • 736 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Control of c-myc Regulation in Normal and Neoplastic Cells

1991 • 632 citations

Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells.

1988 • 409 citations

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

1999 • 409 citations

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

2001 • 408 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

The role of c-myc in cell growth

1993 • 365 citations

An alternative pathway for gene regulation by Myc

1997 • 365 citations

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

2001 • 334 citations

Co-regulation of two gene activities by tetracycline via a bidirectional promoter

1995 • 320 citations

THE MANY ROLES OF c-Myc IN APOPTOSIS

1998 • 310 citations

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma

1984 • 259 citations

Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene.

1995 • 259 citations

Control of cell proliferation by Myc

1998 • 251 citations

The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5

2000 • 234 citations

Transcriptional repression by Myc

2003 • 211 citations

Burkitt Lymphoma in the Mouse

2000 • 209 citations

Genome changes and gene expression in human solid tumors

2000 • 192 citations

Genomic Instability and Tumor Progression: Mechanistic Considerations

1992 • 178 citations

Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice

2000 • 152 citations

Identification of virus-coded nonstructural polypeptides in bunyavirus-infected cells

1982 • 95 citations

Annexin V Binds to Positively Selected B Cells

2001 • 90 citations

The B Lymphocyte-Specific Coactivator BOB.1/OBF.1 Is Required at Multiple Stages of B-Cell Development

2001 • 68 citations

Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping.

1997 • 48 citations

c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis

2002 • 39 citations

Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice

1992 • 21 citations

Further studies on chromosome 15 trisomy in murine T‐cell lymphomas: Mapping of the relevant chromosome segment

1988 • 16 citations

Clonal evolution of N-methylnitrosourea-induced C57BL/6J thymic lymphomas by analysis of multiple genetic alterations

1997 • 13 citations

Normal development, oncogenesis and programmed cell death

1998 • 6 citations