MicroRNAs and cancer

The Hallmarks of Cancer

2000 • 27,569 citations

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

2000 • 4,834 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia

2000 • 3,282 citations

Identification of Tissue-Specific MicroRNAs from Mouse

2002 • 3,236 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

2000 • 2,422 citations

MicroRNA maturation: stepwise processing and subcellular localization

2002 • 2,410 citations

bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila

2003 • 2,012 citations

MicroRNAs in plants

2002 • 1,791 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation

2002 • 1,426 citations

Gene silencing in mammals by small interfering RNAs

2002 • 1,403 citations

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

1999 • 1,174 citations

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

2002 • 1,081 citations

The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

2003 • 1,003 citations

Endogenous and Silencing-Associated Small RNAs in Plants[W]

2002 • 908 citations

Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

2001 • 373 citations

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

2003 • 353 citations

Notch Signaling in Cancer

2002 • 340 citations

Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity

2003 • 316 citations

bic, a Novel Gene Activated by Proviral Insertions in Avian Leukosis Virus-Induced Lymphomas, Is Likely To Function through Its Noncoding RNA

1997 • 280 citations

Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors

1997 • 266 citations

Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA

2001 • 258 citations

Computational Genomics of Noncoding RNA Genes

2002 • 249 citations

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.

1996 • 235 citations

Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia

1997 • 212 citations

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia

2001 • 199 citations

T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC

2002 • 184 citations

Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events.

1989 • 172 citations

Avian bic , a Gene Isolated from a Common Retroviral Site in Avian Leukosis Virus-Induced Lymphomas That Encodes a Noncoding RNA, Cooperates with c- myc in Lymphomagenesis and Erythroleukemogenesis

2002 • 156 citations

Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene.

2001 • 154 citations

Ras pathway signals are required for notch-mediated oncogenesis

2000 • 150 citations

Noncoding RNA genes

1999 • 149 citations

The Expression of the let-7 Small Regulatory RNA Is Controlled by Ecdysone during Metamorphosis in Drosophila melanogaster

2002 • 144 citations

Translational regulation of human p53 gene expression.

1996 • 139 citations

Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis

2003 • 126 citations

Loss of heterozygosity at 13q14 and 13q21 in high grade, high stage prostate cancer

2001 • 125 citations

Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia.

1989 • 122 citations

Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.

2001 • 102 citations

B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions

2001 • 97 citations

Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia

2002 • 92 citations

Suppression of malignancy by the 3' untranslated regions of ribonucleotide reductase R1 and R2 messenger RNAs.

1996 • 51 citations

Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame.

1994 • 42 citations

Comprehensive analysis of a large genomic sequence at the putative B-cell chronic lymphocytic leukaemia (B-CLL) tumour suppresser gene locus

2001 • 33 citations

Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia

2002 • 28 citations

Murine leukemia provirus‐mediated activation of the Notch1 gene leads to induction of HES‐1 in a mouse T lymphoma cell line, DL‐3

1999 • 17 citations

Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues.

1997 • 17 citations

Identification of a cell type-specific silencer in the first exon of theHis-1 gene

2000 • 7 citations