Did Protein Kinase Regulatory Mechanisms Evolve Through Elaboration of a Simple Structural Component?

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

RASMOL: biomolecular graphics for all

1995 • 2,601 citations

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

1998 • 2,048 citations

The Conformational Plasticity of Protein Kinases

2002 • 1,691 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

Regulation of Protein Kinases

2004 • 1,103 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

2002 • 925 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Structural Basis for the Autoinhibition of c-Abl Tyrosine Kinase

2003 • 843 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Visualizing and quantifying molecular goodness-of-fit: small-probe contact dots with explicit hydrogen atoms 1 1Edited by J. Thornton

1999 • 523 citations

Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

2000 • 515 citations

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1999 • 478 citations

A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia

1995 • 464 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

2002 • 416 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I

1996 • 329 citations

Novel Families of Putative Protein Kinases in Bacteria and Archaea: Evolution of the “Eukaryotic” Protein Kinase Superfamily

1998 • 311 citations

PKA: a portrait of protein kinase dynamics

2003 • 304 citations

Positioning hydrogen atoms by optimizing hydrogen-bond networks in protein structures

1996 • 297 citations

Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

2004 • 279 citations

Crystal Structure of the Atypical Protein Kinase Domain of a TRP Channel with Phosphotransferase Activity

2001 • 268 citations

More hydrogen bonds for the (structural) biologist

2001 • 244 citations

Structure of an Enzyme Required for Aminoglycoside Antibiotic Resistance Reveals Homology to Eukaryotic Protein Kinases

1997 • 235 citations

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase.

1994 • 231 citations

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

2002 • 207 citations

The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation

2001 • 194 citations

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

2000 • 192 citations

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

1998 • 191 citations

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

1995 • 187 citations

Switching on kinases: oncogenic activation of BRAF and the PDGFR family

2004 • 180 citations

Structural Basis for Nucleotide Exchange and Competition with tRNA in the Yeast Elongation Factor Complex eEF1A:eEF1Bα

2000 • 175 citations

The Role of Mg2+ Cofactor in the Guanine Nucleotide Exchange and GTP Hydrolysis Reactions of Rho Family GTP-binding Proteins

2000 • 172 citations

Sequence space, folding and protein design

1996 • 157 citations

Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2α

2004 • 145 citations

Structure of the Tie2 RTK Domain

2000 • 143 citations

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. Wilson

1999 • 138 citations

Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure

2003 • 134 citations

Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export

2002 • 131 citations

Domain movements in protein kinases

1994 • 129 citations

Alpha-kinases: analysis of the family and comparison with conventional protein kinases

2003 • 129 citations

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

2002 • 121 citations

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

2004 • 116 citations

Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.

2001 • 112 citations

Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange

2001 • 109 citations

Processive phosphorylation of alternative splicing factor/splicing factor 2

2003 • 104 citations

The Crystal Structure of Aminoglycoside-3′-Phosphotransferase-IIa, an Enzyme Responsible for Antibiotic Resistance

2003 • 103 citations

Cluster analysis of consensus water sites in thrombin and trypsin shows conservation between serine proteases and contributions to ligand specificity

1998 • 83 citations

Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A

1998 • 77 citations

Crystal Structure of A. fulgidus Rio2 Defines a New Family of Serine Protein Kinases

2004 • 77 citations

Phosphorylation Driven Motions in the COOH-terminal Src Kinase, Csk, Revealed Through Enhanced Hydrogen–Deuterium Exchange and Mass Spectrometry (DXMS)

2002 • 77 citations

Participation of ADP Dissociation in the Rate-Determining Step in cAMP-Dependent Protein Kinase

1997 • 77 citations

Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein 1 1Edited by G. von Heijne

1999 • 74 citations

Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine Kinase

2001 • 73 citations

The structure of Sky1p reveals a novel mechanism for constitutive activity.

2001 • 72 citations

The Crystal Structure of Choline Kinase Reveals a Eukaryotic Protein Kinase Fold

2003 • 68 citations

Analysis of Two-residue Turns in Proteins

1994 • 66 citations

Interior turns in globular proteins

1983 • 64 citations

Catalytically Active MAP KAP Kinase 2 Structures in Complex with Staurosporine and ADP Reveal Differences with the Autoinhibited Enzyme

2003 • 63 citations

Allosteric Network of cAMP-dependent Protein Kinase Revealed by Mutation of Tyr204 in the P+1 Loop

2004 • 62 citations

A Single Amino Acid Exchange Inverts Susceptibility of Related Receptor Tyrosine Kinases for the ATP Site Inhibitor STI-571

2003 • 61 citations

Dynamic Coupling Between the SH2 Domain and Active Site of the COOH Terminal Src Kinase, Csk

2004 • 48 citations

Phosphatidylinositol Phosphate Kinase: A Link between Protein Kinase and Glutathione Synthase Folds

1999 • 46 citations

Structural Characterization of Protein Kinase A as a Function of Nucleotide Binding

2001 • 46 citations

Ran's C-terminal, Basic Patch, and Nucleotide Exchange Mechanisms in Light of a Canonical Structure for Rab, Rho, Ras, and Ran GTPases

2003 • 43 citations

Unconventional interactions between water and heterocyclic nitrogens in protein structures

2004 • 40 citations

Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model

2004 • 36 citations

The crystal structure of the Physarum polycephalum actin-fragmin kinase: an atypical protein kinase with a specialized substrate-binding domain

1999 • 36 citations

GEF-mediated GDP/GTP exchange by monomeric GTPases: A regulatory role for Mg2+?

1998 • 33 citations

Lipopolysaccharide phosphorylating enzymes encoded in the genomes of Gram‐negative bacteria are related to the eukaryotic protein kinases

2002 • 26 citations

Communication Pathways between the Nucleotide Pocket and Distal Regulatory Sites in Protein Kinases

2004 • 21 citations

Role of Magnesium in Nucleotide Exchange on the Small G Protein Rac Investigated Using Novel Fluorescent Guanine Nucleotide Analogues

2002 • 16 citations