Defective trophoblast function in mice with a targeted mutation of Ets2

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

The secret life of the hair follicle

1992 • 919 citations

The Ets family of transcription factors

1993 • 848 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1995 • 774 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

1994 • 575 citations

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

1994 • 550 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β

1997 • 414 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Identification of Six Novel Autophosphorylation Sites on Fibroblast Growth Factor Receptor 1 and Elucidation of Their Importance in Receptor Activation and Signal Transduction

1996 • 385 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

Death before birth: clues from gene knockouts and mutations

1995 • 373 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Expression pattern of the Brachyury gene in whole-mount T WIS/T WIS mutant embryos

1991 • 350 citations

Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation

1996 • 345 citations

Defective activation and survival of T cells lacking the Ets-1 transcription factor

1995 • 329 citations

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

1996 • 325 citations

Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.

1994 • 315 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

1996 • 307 citations

Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4−/− embryos

1997 • 295 citations

Bicistronic Vector for the Creation of Stable Mammalian Cell Lines that Predisposes All Antibiotic-Resistant Cells to Express Recombinant Protein

1996 • 288 citations

High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development

1994 • 286 citations

The secret life of the hair follicle

1992 • 243 citations

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths

1992 • 221 citations

Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis.

1994 • 201 citations

Fibroblast growth factors in mammalian development

1995 • 182 citations

Synergistic Transcriptional Activation of the Tissue Inhibitor of Metalloproteinases-1 Promoter via Functional Interaction of AP-1 and Ets-1 Transcription Factors

1996 • 179 citations

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

1995 • 165 citations

Rapid Phosphorylation of Ets-2 Accompanies Mitogen-Activated Protein Kinase Activation and the Induction of Heparin-Binding Epidermal Growth Factor Gene Expression by Oncogenic Raf-1

1997 • 162 citations

Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells

1981 • 128 citations

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

1996 • 127 citations

Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites.

1994 • 122 citations

Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene.

1989 • 121 citations

Identification and immunoprecipitation of cytoskeletal proteins from murine extra-embryonic endodermal cells.

1981 • 107 citations

Stromelysin in tumor progression and metastasis

1990 • 105 citations

Definition of an Ets1 Protein Domain Required for Nuclear Localization in Cells and DNA-Binding Activity In Vitro

1989 • 98 citations

Secondary Structure of the ETS Domain Places Murine Ets-1 in the Superfamily of Winged Helix-Turn-Helix DNA-Binding Proteins

1994 • 82 citations

Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.

1994 • 77 citations

PU.1 but not ets-2 is essential for macrophage development from embryonic stem cells

1996 • 77 citations

A Short-Lived Nuclear Phosphoprotein Encoded by the Human ets-2 Proto-Oncogene Is Stabilized by Activation of Protein Kinase C

1988 • 66 citations

Definition of an Ets1 protein domain required for nuclear localization in cells and DNA-binding activity in vitro.

1989 • 57 citations

cis regulation of the keratin 18 gene in transgenic mice.

1993 • 55 citations

Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.

1990 • 53 citations

The ETS Family of Transcriptional Regulators

1997 • 50 citations

The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein.

1994 • 49 citations

Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.

1996 • 47 citations

Non-nuclear oncogenes and the regulation of gene expression in transformed cells.

1993 • 42 citations

Metalloproteinases regulate parietal endoderm differentiating and migrating in cultured mouse embryos

1997 • 41 citations

Regulatory Elements in the 5′-Flanking Region and the First Intron Contribute to Transcriptional Control of the Mouse Alpha 1 Type I Collagen Gene

1989 • 40 citations

A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.

1988 • 38 citations

Phosphorylation of Ets1 regulates the complementation of a CSF-1 receptor impaired in mitogenesis.

1996 • 28 citations

The ETS domain protein Pointed-P2 is a target of MAP kinase in the Sevenless signal transduction pathway

1994 • 20 citations

A new pattern for helix–turn–helix recognition revealed by the PU.1 ETS-domain–DNA complex

1998 • 18 citations

The role of metalloproteinases and their inhibitors in regulating mammary epithelial morphology and function in vivo

1995 • 17 citations

cis Regulation of the Keratin 18 Gene in Transgenic Mice

1993 • 13 citations

Murine embryonal carcinoma hybrids: Decreased ability to spontaneously differentiate as a dominant trait

1981 • 12 citations

Molecular organization and differential polyadenylation sites of the human ETS2 gene.

1990 • 12 citations

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 9 citations