X-ray induction of methotrexate resistance due todhfr gene amplification

Genomic sequencing.

1984 • 8,343 citations

Separation of Large DNA Molecules by Contour-Clamped Homogeneous Electric Fields

1986 • 1,525 citations

Gene amplification in cultured animal cells

1984 • 639 citations

GENE AMPLIFICATION

1984 • 580 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.

1988 • 191 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

1981 • 171 citations

Effect of chromosomal position on amplification of transfected genes in animal cells

1984 • 140 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

A structure for amplified DNA

1983 • 127 citations

Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

1983 • 118 citations

Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

1989 • 96 citations

Hamster cells with increased rates of DNA amplification, a new phenotype

1987 • 83 citations

Quantitative and Molecular Analyses of Radiation-Induced Mutation in AS52 Cells

1986 • 82 citations

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin.

1987 • 80 citations

Circular DNA of 3T6R50 double minute chromosomes

1988 • 65 citations

Mutation to ouabain-resistance in Chinese hamster cells: Induction by ethyl methanesulphonate and lack of induction by ionising radiation

1978 • 62 citations

Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification.

1986 • 52 citations

Moderate-Level Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells is Accompanied by Chromosomal Translocations At or Near the Site of the Amplified DHFR Gene

1984 • 51 citations

X irradiation and sister chromatid exchange in cultured human lymphocytes

1980 • 51 citations

The role of poly(ADP-ribose) synthesis in toxicity and repair of DNA damage

1985 • 44 citations

Rapid emergence of methotrexate resistance in cultured mouse cells.

1984 • 39 citations

Mathematical Analysis of Mutation-Induction Kinetics

1980 • 37 citations

Enhancement of the frequency of methotrexate resistance by gamma-radiation in Chinese hamster ovary and mouse 3T6 cells.

1989 • 34 citations

A cytogenetic investigation of DNA rereplication after hydroxyurea treatment: implications for gene amplification

1986 • 31 citations

Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene.

1984 • 31 citations

X-rays mutate human lymphoblast cells at genetic loci that should respond only to point mutagens

1986 • 30 citations

The role of acentric chromosome fragments in gene amplification

1987 • 30 citations

Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification.

1987 • 26 citations

Spontaneous and 3-aminobenzamide-induced sister-chromatid exchange frequencies estimated by ring chromosome analysis

1986 • 19 citations

Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-Aminobenzamide

1987 • 13 citations

Induction of CAD gene amplification by restriction endonucleases in V79,B7 Chinese hamster cells

1989 • 11 citations