Moderate-Level Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells is Accompanied by Chromosomal Translocations At or Near the Site of the Amplified DHFR Gene

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure

1979 • 1,403 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Two Types of Ribosome in Mouse–Hamster Hybrid Cells

1971 • 577 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Unequal Crossover and the Evolution of Multigene Families

1974 • 360 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster

1980 • 301 citations

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1974 • 277 citations

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1976 • 237 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

SISTER CHROMATID EXCHANGE FORMATION

1981 • 182 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Chromosome stability in CHO cells

1977 • 155 citations

REDUNDANT GENES

1975 • 151 citations

Gene amplification and gene correction in somatic cells

1982 • 149 citations

Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

1982 • 136 citations

A structure for amplified DNA

1983 • 127 citations

Report of the committee on chromosome markers

1976 • 108 citations

Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate

1980 • 106 citations

Gene amplification proceeds by a chromosome copy mechanism

1972 • 97 citations

Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase

1980 • 88 citations

[27] Karyotyping

1979 • 86 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

Genetic characterization of methotrexate-resistant chinese hamster ovary cells

1976 • 41 citations

Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells

1977 • 37 citations

Antifolate-resistant chinese hamster cells. Evidence from independently derived sublines for the overproduction of two dihydrofolate reductases encoded by different mRNAs.

1980 • 36 citations

Chromosomal Alterations Associated with Overproduction of Asparagine Synthetase in Albizziin-Resistant Chinese Hamster Ovary Cells

1983 • 35 citations

Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.

1982 • 33 citations

Overproduction of Dihydrofolate Reductase and Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells

1982 • 15 citations

The use of selection and counterselection in microcell-mediated transfer of dominant genetic markers

1981 • 5 citations