Gene amplification in a single cell cycle in Chinese hamster ovary cells.

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Specific Gene Amplification in Oocytes

1968 • 811 citations

Fluorescence Activated Cell Sorting

1972 • 774 citations

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

1982 • 630 citations

A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

1983 • 485 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

Amplification of genes for chorion proteins during oogenesis in Drosophila melanogaster

1980 • 301 citations

Effects of Hydroxyurea and 1‐β‐D‐Arabinofuranosyl‐cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

1971 • 280 citations

The organization and amplification of two chromosomal domains containing drosophila chorion genes

1981 • 260 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

Hydroxyurea

1975 • 234 citations

Studies on Simian Virus 40 Excision from Cellular Chromosomes

1979 • 206 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

1981 • 171 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

1982 • 136 citations

Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter

1978 • 131 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

A structure for amplified DNA

1983 • 127 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

Novel amplification and transcriptional activity of chorion genes in Drosophila melanogaster follicle cells

1983 • 112 citations

Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting.

1983 • 106 citations

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

1981 • 104 citations

S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells.

1981 • 94 citations

The temporal order of replication of murine immunoglobulin heavy chain constant region sequences corresponds to their linear order in the genome

1982 • 93 citations

Gene-amplification model of carcinogenesis.

1981 • 86 citations

Selective overproduction of adenosine deaminase in cultured mouse cells.

1983 • 75 citations

Amplification and rearrangement of onc genes in mammalian species

1982 • 56 citations

Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1981 • 53 citations

The Temporal Order of Replication of Some DNA Cistrons

1974 • 48 citations

General Method for Cloning Amplified DNA by Differential Screening with Genomic Probes

1982 • 47 citations

Production of DNA bifilarly substituted with bromodeoxyuridine in the first round of synthesis: branch migration during isolation of cellular DNA

1978 • 39 citations

Mouse 3T6 cells that overproduce glutamine synthetase.

1983 • 38 citations

Replication pattern of a large homogenously staining chromosome region in antifolate‐resistant Chinese hamster cell lines

1981 • 38 citations

Unusual base-pairing of newly synthesized DNA in HeLa cells

1979 • 36 citations

Chromosome-Mediated Gene Transfer of Hydroxyurea Resistance and Amplification of Ribonucleotide Reductase Activity

1983 • 36 citations

Relationship between aberrant DNA replication and loss of cell viability in Chinese hamster ovary CHO-K1 cells.

1982 • 13 citations