UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

1982 • 630 citations

A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells

1983 • 485 citations

Tumor Promoters and the Mechanism of Tumor Promotion

1980 • 415 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

Chemical characterization of 465 known or suspected carcinogens and their correlation with mutagenic activity in the Salmonella typhimurium system.

1979 • 267 citations

Chromosomes and cancer

2009 • 266 citations

Induction of replication by thymine starvation at the chromosome origin in Escherichia coli

1964 • 262 citations

Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.

1983 • 244 citations

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

1983 • 239 citations

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells

1976 • 237 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts.

1981 • 212 citations

Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

1977 • 195 citations

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

1981 • 191 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

1981 • 171 citations

Resistance to methotrexate due to gene amplification in a patient with acute leukemia.

1984 • 145 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Inhibition of DNA replication by ultraviolet light

1976 • 125 citations

Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

1983 • 118 citations

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

1981 • 114 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

1981 • 104 citations

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases.

1980 • 100 citations

Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.

1981 • 96 citations

The remarkable instability of replication loops provides a general method for the isolation of origins of DNA replication

1981 • 92 citations

Replication of the Bacterial Chromosome: Location of New Initiation Sites After Irradiation

1969 • 75 citations

Ultraviolet Irradiation of Mouse L Cells: Effects on DNA Synthesis and Progression through the Cell Cycle

1968 • 73 citations

Nitrosoguanidine mutagenesis in synchronized hamster cells

1971 • 62 citations

Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.

1983 • 61 citations

Deoxyribonucleic acid replication in bacteria following ultraviolet irradiation

1963 • 57 citations

Cloning of DNA from double minutes of Y1 mouse adrenocortical tumor cells: Evidence for gene amplification

1981 • 56 citations

Amplification and rearrangement of onc genes in mammalian species

1982 • 56 citations

Effects of promoters on DNA synthesis in C3H/10T1/2 mouse fibroblasts.

1977 • 55 citations

Evidence for double replication of chromosomal DNA segments as a general consequence of DNA replication inhibition.

1981 • 45 citations

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.

1982 • 43 citations

Homogeneously staining chromosome regions and double minutes in a mouse adrenocortical tumor cell line

1980 • 43 citations

Amplification and Loss of Dihydrofolate Reductase Genes in a Chinese Hamster Ovary Cell Line

1981 • 42 citations

Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.

1982 • 41 citations

Chapter 2 Cloning of Mammalian Cells

1972 • 32 citations

Isolation and characterization of dihydrofolic acid reductase from methotrexate-sensitive and -resistant human cell lines.

1981 • 29 citations

Loss and Stabilization of Amplified Dihydrofolate Reductase Genes in Mouse Sarcoma S-180 Cell Lines

1981 • 28 citations

A heterochromatic homogeneously staining region (HSR) in the karyotype of a human breast carcinoma cell line

1980 • 22 citations

Overproduction of Dihydrofolate Reductase and Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells

1982 • 15 citations

Chromosomes and Cancer

1977 • 5 citations

Deleted Work

1955 • 0 citations