Stromelysin-3: a paradigm for stroma-derived factors implicated in carcinoma progression

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

[13] Evolutionary families of metallopeptidases

1995 • 794 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Matrix metal loproteinases and the development of cancer

1996 • 569 citations

The biology of SPARC, a protein that modulates cell‐matrix interactions

1994 • 533 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

The Family of Matrix Metalloproteinases^a

1994 • 437 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.

1994 • 391 citations

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.

1993 • 383 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.

1994 • 345 citations

Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic

1996 • 337 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Proteases as prognostic markers in cancer.

1996 • 319 citations

Cancer Cell Invasion and Metastasis

1992 • 260 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution

1997 • 254 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 244 citations

Structure and expression of the human gene for the matrix metalloproteinase matrilysin.

1994 • 243 citations

Oncogenes as inducers of tumor angiogenesis

1995 • 241 citations

Structural features of a superfamily of zinc-endopeptidases: the metzincins

1995 • 236 citations

Matrix metalloproteinase inhibition: A review of anti-tumour activity

1995 • 226 citations

Stromal Involvement In Malignant Growth

1988 • 225 citations

Expression of Matrix Metalloproteinases during Rat Skin Wound Healing: Evidence that Membrane Type-1 Matrix Metalloproteinase Is a Stromal Activator of Pro-Gelatinase A

1997 • 225 citations

Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.

1993 • 222 citations

The Modulating Influence of Stromal Environment on Epithelial Cells Studied in Human Autotransplants11From the Dermatology Service, General Medicine Branch, National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda, Maryland.Presented at the Twenty-first Annual Meeting of The Society for Investigative Dermatology, Inc., Miami Beach, Florida, June 13, 1960.

1961 • 219 citations

Inhibition of the metastatic spread and growth of B16‐BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

1994 • 218 citations

Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

1994 • 217 citations

Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.

1993 • 209 citations

Matrix metalloproteinases as stromal effectors of human carcinoma progression: Therapeutic implications

1997 • 207 citations

Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ

1996 • 206 citations

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).

1996 • 195 citations

Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.

1994 • 189 citations

The origin of matrix metalloproteinases and their familial relationships

1991 • 182 citations

Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin‐3 and BM‐40/SPARC genes

1995 • 174 citations

The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.

1992 • 173 citations

Role of mesenchymal-epithelial interactions in mammary gland development

1996 • 169 citations

Transcriptional Activation of the Matrix Metalloproteinase Gene stromelysin-3 Coincides with Thyroid Hormone-Induced Cell Death during Frog Metamorphosis

1995 • 165 citations

lnterleukin-1 Stimulates andAll-Trans-Retinoic Acid Inhibits Collagenase Gene Expression through Its 5′ Activator Protein-1-Binding Site

1990 • 154 citations

Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas

1992 • 143 citations

Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development.

1996 • 142 citations

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

1994 • 135 citations

The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase

1993 • 132 citations

Matrilysin Is Much More Efficient Than Other Matrix Metalloproteinases in the Proteolytic Inactivation of α1-Antitrypsin

1994 • 128 citations

Breast-Cancer-Associated Stromelysin-3 Gene Is Expressed in Basal Cell Carcinoma and During Cutaneous Wound Healing

1992 • 127 citations

The role of fibroblasts in tumor behavior

1995 • 125 citations

Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase

1996 • 123 citations

High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma

1996 • 107 citations

Stromelysin-3 gene expression in human cancer: an overview.

1994 • 104 citations

Developmental expression of mouse stromelysin-3 mRNA

1995 • 98 citations

Stromelysin-3 expression promotes tumor take in nude mice.

1996 • 92 citations

Matrix Metalloproteinase MMP-19 (RASI-1) is Expressed on the Surface of Activated Peripheral Blood Mononuclear Cells and is Detected as an Autoantigen in Rheumatoid Arthritis

1998 • 91 citations

The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.

1996 • 88 citations

Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.

1988 • 87 citations

Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.

1995 • 83 citations

Correlation between stromelysin‐3 mRNA level and outcome of human breast cancer

1994 • 76 citations

Localization by In Situ Hybridization of mRNAs Encoding Stromelysin 3 and Tissue Inhibitors of Metallo-Proteinases TIMP-1 and TIMP-2 in Human Head and Neck Carcinomas*

1993 • 75 citations

Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

1996 • 74 citations

Identification of Structural Determinants Controlling Human and Mouse Stromelysin-3 Proteolytic Activities

1995 • 72 citations

Structure and Promoter Characterization of the Human Stromelysin-3 Gene

1995 • 66 citations

Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor

1994 • 65 citations

Metalloproteinase super–families and drug design

1994 • 62 citations

Building a Market Economy in Poland

1992 • 60 citations

Expression Pattern of Metalloproteinases and Their Inhibitors Changes with the Progression of Human Sporadic Colorectal Neoplasia

1993 • 58 citations

Proteolysis of human native and oxidised α1-proteinase inhibitor by matrulysin and stromelysin

1994 • 54 citations

Stromelysin-3 mRNA Associated with Myofibroblasts Is Overexpressed in Aggressive Basal Cell Carcinoma and in Dermatofibroma but Not in Dermatofibrosarcoma

1996 • 53 citations

Accelerated mammary cancer development by fetal salivary mesenchyma isografted to adult mouse mammary epithelium.

1981 • 50 citations

Stromelysin-3 Induction and Interstitial Collagenase Repression by Retinoic Acid

1997 • 49 citations

The Development of Biological Therapies for Breast Cancer

1993 • 49 citations

Remodeling MMPIs

1995 • 49 citations

Increased expression of stromelysin‐3 in basal cell carcinomas

1994 • 46 citations

Understanding the P₁‘ Specificity of the Matrix Metalloproteinases: Effect of S₁‘ Pocket Mutations in Matrilysin and Stromelysin-1

1996 • 45 citations

Stromelysin‐3 expression in breast cancer biopsies: Clinico‐pathological correlations

1993 • 43 citations

Expression Pattern of Metalloproteinases and Their Inhibitors Changes with the Progression of Human Sporadic Colorectal Neoplasia

1993 • 42 citations

Expression of stromelysin-3 in the human placenta and placental bed

1997 • 42 citations

Patent Update Oncologic, Endocrine & Metabolic: Oncologic, Endocrine & Metabolic: Recent advances in the field of matrix metalloproteinase inhibitors

1996 • 37 citations

Sequence Requirements for Endoproteolytic Processing of Precursor Proteins by Fur in: Transfection and In Vitro Experiments1

1994 • 34 citations

Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22

1992 • 32 citations

Expression of Stromelysin 3 in the Stromal Elements of Human Basal Cell Carcinoma

1992 • 30 citations

Stromelysin-3 mRNA expression and malignancy: comparison with clinicopathological features and type IV collagenase mRNA expression in breast tumors.

1993 • 24 citations

Amplification of stromelysin-3 transcripts from carcinomas of the colon

1996 • 21 citations

Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues

1997 • 21 citations

Expression of stromelysin‐3 and nm23 in breast carcinoma and related tissues

1994 • 15 citations

Comparative expression of the SPARC and stromelysin-3 genes in mammary tumours

1996 • 15 citations

PCR Production of a Digoxigenin-labeled Probe for the Detection of Human Cytomegalovirus in Tissue Sections

1994 • 11 citations

The challenge of cancer research

1993 • 4 citations

Activité biologique des différentes zones obtenues par ultracentrifugation du facteur lacté de la souche de souris PS sur gradients préformés de Ficoll

1970 • 2 citations