Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin‐3 and BM‐40/SPARC genes

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

THE PROGNOSTIC SIGNIFICANCE OF DIRECT EXTENSION OF CARCINOMA OF THE COLON AND RECTUM

1954 • 1,110 citations

The Spread of Rectal Cancer and its Effect on Prognosis

1958 • 807 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin

1991 • 560 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Natural history of patients with untreated liver metastases from colorectal cancer

1981 • 438 citations

Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.

1990 • 417 citations

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.

1989 • 375 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

1993 • 283 citations

SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.

1993 • 274 citations

Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.

1993 • 222 citations

Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.

1993 • 207 citations

Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts

1993 • 139 citations

The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase

1993 • 132 citations

Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor β

1991 • 121 citations

Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1.

1992 • 96 citations

Cloning and complete amino acid sequences of human and murine basement membrane protein BM‐40 (SPARC, osteonectin)

1988 • 76 citations

Stromelysin‐3 expression in breast cancer biopsies: Clinico‐pathological correlations

1993 • 43 citations

Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes

1993 • 33 citations

Detection by in Situ Hybridization of HIV I RNA in Spleens of HIV I Sero-Positive Patients with Thrombocytopenic Purpura

1989 • 14 citations