The role of fibroblasts in tumor behavior

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Growth Factors and Cancer

1991 • 2,044 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction

1971 • 1,458 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Ciba Foundation Symposium

1965 • 1,026 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

1990 • 677 citations

Growth factors and wound healing: Biochemical properties of growth factors and their receptors

1993 • 650 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

The biology of SPARC, a protein that modulates cell‐matrix interactions

1994 • 533 citations

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

1994 • 522 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.

1991 • 509 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.

1991 • 449 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity

1994 • 431 citations

Fibrogenic cytokines and connective tissue production

1994 • 425 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites

1988 • 405 citations

Peptide growth factors and inflammation, tissue repair, and cancer.

1986 • 360 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue.

1993 • 320 citations

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

1993 • 283 citations

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.

1992 • 242 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Antibody targeting in metastatic colon cancer: a phase I study of monoclonal antibody F19 against a cell-surface protein of reactive tumor stromal fibroblasts.

1994 • 240 citations

Influence of Organ Environment on Extracellular Matrix Degradative Activity and Metastasis of Human Colon Carcinoma Cells

1990 • 238 citations

Production of transforming growth factors by human colon cancer lines.

1986 • 227 citations

Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex.

1989 • 225 citations

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

1991 • 217 citations

Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer.

1989 • 189 citations

Growth factor production by human colon carcinoma cell lines.

1989 • 186 citations

Type IV collagenase (M(r) 72,000) expression in human prostate: benign and malignant tissue.

1993 • 181 citations

Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin‐3 and BM‐40/SPARC genes

1995 • 174 citations

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

1991 • 174 citations

Association of transforming growth factor-β1 with prostate cancer: An immunohistochemical study

1993 • 170 citations

Modulation of tumor cell response to chemotherapy by the organ environment

1994 • 161 citations

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

1992 • 154 citations

Participation of tenascin and transforming growth factor-beta in reciprocal epithelial-mesenchymal interactions of MCF7 cells and fibroblasts.

1989 • 150 citations

Elevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinoma.

1991 • 150 citations

Tumor invasion: A consequence of destructive and compositional matrix alterations

1988 • 146 citations

Expression of transforming growth factor alpha in normal human adult kidney and enhanced expression of transforming growth factors alpha and beta 1 in renal cell carcinoma.

1989 • 143 citations

Mechanisms of tumor invasion: evidence from in vivo observations

1985 • 142 citations

An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice.

1991 • 139 citations

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

1992 • 134 citations

Localization of basic fibroblast growth factor and transforming growth factor beta 1 in the human mammary gland.

1991 • 123 citations

Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review

1993 • 123 citations

Selective inactivity of TGF‐β/decorin complexes

1994 • 118 citations

MEDICAL ONCOLOGY

1977 • 116 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Transforming growth factor-βs are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation

1988 • 106 citations

The Tumor-Promoting Effect of Wounding: A Possible Role for TGF-β-lnduced Stromal Alterations

1994 • 100 citations

Characterization of an immunosuppressive factor derived from colon cancer cells.

1987 • 96 citations

Desmoplasia and its relevance to colorectal tumour invasion

1993 • 95 citations

The invasive phenotypes

1990 • 94 citations

Stromal myofibroblasts in primary invasive and metastatic carcinomas

1981 • 93 citations

Expression of 7F7‐antigen, a human adhesion molecule identical to intercellular adhesion molecule‐1 (ICAM‐1) in human carcinomas and their stromal fibroblasts

1989 • 89 citations

Pleiotropic Effects of Transforming Growth Factor‐β on Cells of the Immune System

1993 • 87 citations

Invasion and metastasis

1992 • 83 citations

Regulatory pathways in tumor growth and invasion.

1991 • 76 citations

Effects of Transforming Growth Factor-beta on Human Pulmonary Adenocarcinoma Cell Adhesion, Motility, and Invasion In Vitro

1992 • 73 citations

Transforming growth factor β1 as a biomarker for prostate cancer

1992 • 71 citations

The role of transforming growth factor beta 1 in the fibroblastic reaction associated with rat colorectal tumor development.

1994 • 70 citations

Myofibroblasts in human pathology

1981 • 67 citations

Role of Transforming Growth Factor-β in Repair and Fibrosis

1991 • 62 citations

Lack of the latent transforming growth factor beta binding protein in malignant, but not benign prostatic tissue.

1993 • 61 citations

Stromelysin-3 in stromal tissue as a control factor in breast cancer behavior

1994 • 61 citations

Stromal cell changes in human colorectal adenomas and carcinomas

1983 • 60 citations

Cytoskeletal and Cytocontractile Protein Composition of Smooth Muscle Cells in Developing and Obstructed Rabbit Bladder

1993 • 54 citations

Transplantation of colon carcinoma into granulation tissue induces an invasive morphotype

1993 • 54 citations

Inhibition by tranilast of collagen accumulation in hypersensitive granulomatous inflammation in vivo and of morphological changes anf functions of fibroblasts in vitro

1994 • 46 citations

Tenascin induction in tenascin nonproducing carcinoma cell lines in vivo and by TGF‐β1 in vitro

1994 • 45 citations

Peptide growth factors and wound healing

1991 • 45 citations

Inhibition of lymphokine-activated killer cell generation by cultured tumor cell lines in vitro

1989 • 43 citations

α-Smooth Muscle Actin Expression in Tumor and Stromal Cells of Benign and Malignant Human Pigment Cell Tumors

1992 • 41 citations

The invasive edge: invasion in colorectal cancer

1986 • 39 citations

Role of Orthotopic Fibroblasts in the Development of Scirrhous Gastric Carcinoma

1994 • 39 citations

Immunohistologic analysis of the extracellular matrix components of the fibrous stroma of human colon cancer

1993 • 39 citations

Identification and characterization of a novel membrane activation antigen with wide cellular distribution

1988 • 39 citations

Cell-matrix interactions during tumor invasion

1990 • 38 citations

High Frequency of Resistance of Human Squamous Carcinoma Cells to the Anti-proliferative Action of Transforming Growth Factor β

1990 • 37 citations

Characterization of transforming growth factor-beta-resistant subclones isolated from a transforming growth factor-beta-sensitive human colon carcinoma cell line.

1988 • 37 citations

Morphological observations during developing concomitant immunity against a C3H/He mammary tumor.

1985 • 37 citations

Reaction of α2-macroglobulin with plasmin increases binding of transforming growth factors-β1 and β2

1991 • 36 citations

Extracellular matrix contraction by fibroblasts: Peptide promoters and second messengers

1992 • 31 citations

Suppression of the generation of lymphokine-activated killer (LAK) cells by serum-free supernatants of in vitro maintained tumour cell lines

1989 • 30 citations

Potentiation of Metastatic Capacity by Transforming Growth Factor‐β1 Gene Transfection

1993 • 30 citations

Identification of endogenous inhibitory growth factors from a human colon carcinoma cell line.

1985 • 30 citations

Collagen production by macrophages in tumour encapsulation and dormancy

1991 • 29 citations

An Orthotopic Model for the Study of Growth Factors in the Ventral Prostate of the Rat: Effects of Epidermal Growth Factor and Basic Fibroblast Growth Factor

1994 • 28 citations

Relationships between epithelial basement membrane staining patterns in primary colorectal carcinomas and the extent of tumour spread

1991 • 27 citations

ENCAPSULATION OF TUMOURS AS A MODIFIED WOUND HEALING RESPONSE

1988 • 21 citations

Secretion of a TGF‐β‐like growth inhibitor by normal rat mammary epithelial cells in vitro

1990 • 20 citations

Cytokines and fibrosis

1994 • 16 citations

Smooth muscle myosin regulation by serum and cell density in cultured rat lung connective tissue cells

1993 • 16 citations

Possible involvement of TGF beta 1 in the distinct tumorigenic properties of two rat colon carcinoma clones.

1992 • 12 citations

TGF‐β: A Possible Autocrine Immune Regulator

2007 • 10 citations

Immunologic aspects of fibrosis in mouse mammary carcinomas

1992 • 8 citations

Tumor Cell Subpopulation Interactions Mediated by Transforming Growth Factor � May Contribute to Clonal Dominance of Metastatically Competent Cells in Primary Tumors

2015 • 4 citations

[Role of TGF beta 1 in the stromal reaction to human colonic tumors].

1993 • 1 citations