The biology of SPARC, a protein that modulates cell‐matrix interactions

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin

1991 • 560 citations

Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization

1988 • 519 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.

1989 • 375 citations

The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

1992 • 358 citations

Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell ‘culture shock’ glycoprotein of Mr 43,000.

1986 • 315 citations

In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.

1987 • 292 citations

Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]

1991 • 281 citations

SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway.

1993 • 274 citations

Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture.

1984 • 264 citations

The Epidermal Growth Factor Family

1991 • 260 citations

Follistatin Binds to both Activin and Inhibin through the Common Beta-Subunit

1991 • 258 citations

The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells.

1991 • 223 citations

Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.

1993 • 217 citations

Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues

1987 • 211 citations

Isolation and characterization of native adult osteonectin.

1985 • 207 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.

1991 • 196 citations

Distribution of the calcium-binding protein SPARC in tissues of embryonic and adult mice.

1989 • 192 citations

Osteonectin cDNA sequence reveals potential binding regions for calcium and hydroxyapatite and shows homologies with both a basement membrane protein (SPARC) and a serine proteinase inhibitor (ovomucoid).

1988 • 189 citations

Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.

1986 • 175 citations

Anti-adhesive molecules of the extracellular matrix

1991 • 166 citations

Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape.

1990 • 164 citations

Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: Sequence, expression, and localization of the gene to chromosome 5q31-q33

1988 • 157 citations

Molecular cloning of SC1: A putative brain extracellular matrix glycoprotein showing partial similarity to osteonectin/BM40/SPARC

1990 • 153 citations

Secretory phenotypes of endothelial cells in culture: comparison of aortic, venous, capillary, and corneal endothelium.

1981 • 146 citations

SPARC antagonizes the effect of basic fibroblast growth factor on the igration of bovine aortic endothelial cells

1992 • 142 citations

Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts

1993 • 139 citations

Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour

1993 • 129 citations

Solubilization of protein BM‐40 from a basement membrane tumor with cheating agents and evidence for its identity with osteonectin and SPARC

1987 • 128 citations

Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor β

1991 • 121 citations

Functions of agrin and agrin-related proteins

1993 • 119 citations

SPARC (secreted protein acidic and rich in cysteine) regulates endothelial cell shape and barrier function.

1994 • 115 citations

Markers of complement-dependent and complement-independent glomerular visceral epithelial cell injury in vivo. Expression of antiadhesive proteins and cytoskeletal changes.

1992 • 109 citations

Calcium‐dependent binding of basement membrane protein BM‐40 (osteonectin, SPARC) to basement membrane collagen type IV

1991 • 107 citations

The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.

1993 • 102 citations

Characterization of porcine osteonectin extracted from foetal calvariae

1988 • 101 citations

Endothelial cell injury in vitro is associated with increased secretion of an M_r 43,000 glycoprotein ligand

1986 • 99 citations

Developmental expression of genes in chick growth cartilage detected byin situ hybridization

1989 • 97 citations

Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1.

1992 • 96 citations

Complex formation of human thrombospondin with osteonectin

1988 • 95 citations

Distribution of osteonectin mRNA and protein during human embryonic and fetal development.

1992 • 85 citations

Structure of human osteonectin based upon analysis of cDNA and genomic sequences

1989 • 83 citations

Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region.

1988 • 82 citations

High‐affinity and low‐affinity calcium binding and stability of the multidomain extracellular 40‐kDa basement membrane glycoprotein (BM‐40/SPARC/osteonectin)

1992 • 79 citations

The collagen binding specificity of bone and platelet osteonectin is related to differences in glycosylation

1991 • 78 citations

Distinct patterns of glycosylation of colligin, a collagen‐binding glycoprotein, and SPARC (osteonectin), a secreted Ca²⁺‐binding glycoprotein

1987 • 77 citations

Cloning and complete amino acid sequences of human and murine basement membrane protein BM‐40 (SPARC, osteonectin)

1988 • 76 citations

Extracellular matrix formation by osteoblasts from patients with osteogenesis imperfecta

1992 • 73 citations

SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells

1991 • 70 citations

Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.

1991 • 67 citations

Biosynthesis of osteonectin by fetal porcine calvarial cells in vitro.

1984 • 66 citations

Biosynthesis of bone proteins by fetal porcine calvariae in Vitro. Rapid association of sulfated sialoproteins (Secreted Phosphoprotein-1 and Bone Sialoprotein) and chondroitin sulfate proteoglycan (CS-PGIII) with bone mineral

1991 • 66 citations

Characterization of human osteoblast and megakaryocyte-derived osteonectin (SPARC)

1992 • 63 citations

Osteonectin Promoter

1989 • 60 citations

Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea.

1991 • 59 citations

[28] Biological activity of human plasma copper-binding growth factor glycyl-l-histidyl-l-lysine

1987 • 57 citations

Localization of platelet osteonectin at the internal face of the alpha- granule membranes in platelets and megakaryocytes

1992 • 55 citations

Developmental anomalies ofXenopus embryos following microinjection of SPARC antibodies

1993 • 49 citations

Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence containing a calcium-binding EF hand.

1993 • 49 citations

Evidence for Positive and Negative Regulatory Elements in the 5′-Flanking Sequence of the Mouse Sparc (osteonectin) Gene

1989 • 48 citations

Degradation of bone matrix proteins by osteoclast cathepsins

1993 • 47 citations

The Calcium-Binding Protein SPARC is Secreted by Leydig and Sertoli Cells of the Adult Mouse Testis1

1989 • 44 citations

Isolation of the osteonectin gene: evidence that a variable region of the osteonectin molecule is encoded within one exon

1988 • 43 citations

Heat‐shock response in cultured chick embryo chondrocytes

1992 • 42 citations

Modulation of SPARC Expression during Butyrate-Induced Terminal Differentiation of Cultured Human Keratinocytes: Regulation via a TGF-β-Dependent Pathway

1993 • 42 citations

The osteonectin family of proteins

1988 • 37 citations

The Regulation of the Expression of Genes Encoding Basement Membrane Proteins during the Retinoic Acid‐Associated Differentiation of Murine Teratocarcinoma Cells^a

1990 • 29 citations

Expression of SPARC is correlated with altered morphologies in transfected F9 embryonal carcinoma cells

1992 • 28 citations

Intertissular variations in osteonectin: A monoclonal antibody directed to bone osteonectin shows reduced affinity for platelet osteonectin

1991 • 27 citations

Expression and structure of human SPARC transcripts: SPARC mRNA is expressed by human cells involved in extracellular matrix production and some of these cells show an unusual expression pattern

1990 • 22 citations

Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro

1992 • 21 citations

A linkage map spanning the locus for diastrophic dysplasia (DTD)

1991 • 19 citations

Transcriptional Downregulation of the Retina-Specific QR1 Gene by pp60^v-src and Identification of a Novel v-src-Responsive Unit

1993 • 18 citations

Expression of the osteonectin gene potentially controlled by multiple Cis- and trans-acting factors in cultured bone cells

1991 • 18 citations

Modulation of endothelial cell shape by SPARC does not involve chelation of extracellular Ca²⁺ and Mg²⁺

1992 • 15 citations

Partial characterization of a novel ‘GGA’factor which binds to the osteonectin promoter in bovine bone cells

1993 • 14 citations

Overexpression of SPARC in stably transfected F9 cells mediates attachment and spreading in Ca²⁺-deficient medium

1992 • 13 citations

Ezrin and Osteonectin, Two Proteins Associated with Cell Shape and Growth, Are Enriched in the Locus Coeruleus

1993 • 10 citations

Expression and distribution of SPARC in early Xenopus laevis embryos

1992 • 10 citations

Cytokines alter mRNA steady state levels for basement membrane proteins in human skin fibroblasts

1991 • 9 citations

Cited By (0)

Loading...