Stromelysin-3 Induction and Interstitial Collagenase Repression by Retinoic Acid

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

1982 • 727 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

The war on cancer

1996 • 684 citations

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

1995 • 620 citations

Retinoic Acid Receptors and Cellular Retinoid Binding Proteins: Complex Interplay in Retinoid Signaling*

1994 • 514 citations

Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas.

1995 • 511 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 449 citations

Nuclear Receptor/AP-1 Interaction*

1993 • 435 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Patterns of matrix metalloproteinase expression in cycling endometrium imply differential functions and regulation by steroid hormones.

1994 • 391 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic

1996 • 337 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

Matrix metalloproteinase–1 is associated with poor prognosis in colorectal cancer

1996 • 312 citations

RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.

1995 • 257 citations

Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.

1994 • 217 citations

Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells

1985 • 215 citations

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ

1992 • 205 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.

1994 • 179 citations

The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.

1992 • 173 citations

Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells.

1990 • 173 citations

Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C

1990 • 170 citations

Separation of Transactivation and AP1 Antagonism Functions of Retinoic Acid Receptor α

1995 • 168 citations

Widely Spaced, Directly Repeated PuGGTCA Elements Act as Promiscuous Enhancers for Different Classes of Nuclear Receptors

1995 • 167 citations

Matrix metalloproteinases and their inhibitors

1995 • 165 citations

Transcriptional Activation of the Matrix Metalloproteinase Gene stromelysin-3 Coincides with Thyroid Hormone-Induced Cell Death during Frog Metamorphosis

1995 • 165 citations

Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.

1993 • 160 citations

lnterleukin-1 Stimulates andAll-Trans-Retinoic Acid Inhibits Collagenase Gene Expression through Its 5′ Activator Protein-1-Binding Site

1990 • 154 citations

Differential Regulation of Retinoic Acid Receptors and Binding Proteins in Human Skin

1992 • 118 citations

Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.

1996 • 113 citations

Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C.

1990 • 112 citations

High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma

1996 • 107 citations

Chromosome 17p deletions and p53 mutations in renal cell carcinoma.

1993 • 104 citations

Stromelysin-3 gene expression in human cancer: an overview.

1994 • 104 citations

Developmental expression of mouse stromelysin-3 mRNA

1995 • 98 citations

Stromelysin-3 expression promotes tumor take in nude mice.

1996 • 92 citations

Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR'S)

1990 • 84 citations

Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.

1995 • 83 citations

Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.

1995 • 81 citations

Correlation between stromelysin‐3 mRNA level and outcome of human breast cancer

1994 • 76 citations

Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

1996 • 74 citations

Identification of Structural Determinants Controlling Human and Mouse Stromelysin-3 Proteolytic Activities

1995 • 72 citations

Suppression of collagenase gene expression by all‐trans and 9‐cis retinoic acid is ligand dependent and requires both RARs and RXRs

1995 • 69 citations

Structure and Promoter Characterization of the Human Stromelysin-3 Gene

1995 • 66 citations

Retinoic acid receptor and retinoid X receptor expression in retinoic acid—resistant human tumor cell lines

1993 • 50 citations

Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.

1994 • 48 citations

Differential regulation of human ectocervical epithelial cell line proliferation and differentiation by retinoid X receptor- and retinoic acid receptor-specific retinoids.

1996 • 34 citations

Cellular Aging and Transformation Suppression: A Role for Retinoic Acid Receptor β2

1995 • 32 citations

New chemotherapeutic agents for breast cancer

1994 • 32 citations

Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage.

1993 • 29 citations

Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues

1997 • 21 citations