Molecular Targets for AIDS Therapy

The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 3,000 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

1985 • 1,830 citations

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

1988 • 1,488 citations

Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative Disorders

1986 • 1,442 citations

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

1988 • 1,394 citations

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

1986 • 1,348 citations

Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection

1990 • 1,288 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 1,134 citations

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

1986 • 1,032 citations

A controlled trial

1971 • 982 citations

The Accuracy of Reverse Transcriptase from HIV-1

1988 • 982 citations

Non-Hodgkin's Lymphoma in 90 Homosexual Men

1984 • 975 citations

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

1988 • 936 citations

Fidelity of HIV-1 Reverse Transcriptase

1988 • 919 citations

Rational Design of Peptide-Based HIV Proteinase Inhibitors

1990 • 910 citations

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1990 • 899 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

1990 • 845 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

1986 • 806 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 Å Resolution

1989 • 683 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents

1990 • 663 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Occurrence of malignancy in immunodeficiency diseases: A literature review

1971 • 621 citations

Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region

1988 • 617 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

1987 • 569 citations

Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV

1986 • 543 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

1988 • 532 citations

Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

1990 • 531 citations

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

1987 • 530 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms.

1990 • 529 citations

PHASE I STUDIES OF 2',3'-DIDEOXYCYTIDINE IN SEVERE HUMAN IMMUNODEFICIENCY VIRUS INFECTION AS A SINGLE AGENT AND ALTERNATING WITH ZIDOVUDINE (AZT)

1988 • 513 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

Trans -Acting Transcriptional Regulation of Human T-Cell Leukemia Virus Type III Long Terminal Repeat

1985 • 500 citations

Biological Catalysis by RNA

1986 • 496 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

Strategies for antiviral therapy in AIDS

1987 • 480 citations

The HIV A (sor) gene product is essential for virus infectivity

1987 • 475 citations

Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitro.

1989 • 472 citations

Expression of the Rous Sarcoma Virus pol Gene by Ribosomal Frameshifting

1985 • 471 citations

Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.

1988 • 467 citations

Dextran Sulfate Suppression of Viruses in the HIV Family: Inhibition of Virion Binding to CD4 ⁺ Cells

1988 • 465 citations

Tat Protein from Human Immunodeficiency Virus Forms a Metal-Linked Dimer

1988 • 464 citations

The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating

1986 • 462 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes

1989 • 453 citations

Effect of Continuous Intravenous Infusion of Zidovudine (AZT) in Children with Symptomatic HIV Infection

1988 • 452 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

In Vivo Activity Against HIV and Favorable Toxicity Profile of 2′,3′-Dideoxyinosine

1989 • 426 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope

1988 • 412 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

1986 • 403 citations

Retroviral DNA integration: Structure of an integration intermediate

1988 • 397 citations

Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.

1989 • 392 citations

2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 391 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions

1989 • 372 citations

The sor Gene of HIV-1 Is Required for Efficient Virus Transmission in Vitro

1987 • 365 citations

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.

1989 • 357 citations

Clinical Pharmacology of 3'-Azido-2',3'-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides

1989 • 356 citations

Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.

1988 • 355 citations

HIV-1 isolates are rapidly evolving quasispecies: evidence for viral mixtures and preferred nucleotide substitutions.

1989 • 354 citations

RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE

1987 • 352 citations

Recombinant Human Erythropoietin for Patients with AIDS Treated with Zidovudine

1990 • 347 citations

Crystal structure of a retroviral protease proves relationship to aspartic protease family

1989 • 345 citations

Interferon-α But Not AZT Suppresses HIV Expression in Chronically Infected Cell Lines

1989 • 339 citations

Nucleosides. V. The Monomesylates of 1-(2'-Deoxy-β-D-lyxofuranosyl)thymine^1,2

1964 • 337 citations

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

1988 • 336 citations

Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.

1987 • 331 citations

Recombinant Alpha-2 Interferon Therapy for Kaposi's Sarcoma Associated with the Acquired Immunodeficiency Syndrome

1984 • 329 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity

1986 • 326 citations

Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro

1987 • 320 citations

Site-specific mutagenesis of AIDS virus reverse transcriptase

1987 • 319 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus

1987 • 314 citations

Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication.

1987 • 310 citations

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro.

1988 • 309 citations

Productive dual infection of human CD4+ T lymphocytes by HIV-1 and HHV-6

1989 • 308 citations

Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

1988 • 308 citations

GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage.

1989 • 307 citations

RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO

1985 • 306 citations

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

1989 • 293 citations

HTLV-III gag Protein Is Processed in Yeast Cells by the Virus pol -Protease

1986 • 289 citations

Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication

1987 • 282 citations

Functional role of human immunodeficiency virus type 1 vpu.

1989 • 280 citations

Development of Non-Hodgkin Lymphoma in a Cohort of Patients with Severe Human Immunodeficiency Virus (HIV) Infection on Long-Term Antiretroviral Therapy

1990 • 275 citations

Bidirectional Interactions Between Human Immunodeficiency Virus Type 1 and Cytomegalovirus

1988 • 274 citations

Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein

1989 • 267 citations

Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.

1989 • 266 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

1989 • 264 citations

POST-PARTUM PULMONARY ŒDEMA ASSOCIATED WITH PREVENTIVE THERAPY FOR PREMATURE LABOUR

1979 • 259 citations

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

1988 • 257 citations

Integration of human immunodeficiency virus type 1 DNA in vitro.

1990 • 257 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

Once-Daily Administration of 2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 253 citations

Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.

1989 • 243 citations

Potent new inhibitors of human renin

1982 • 239 citations

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon

1987 • 237 citations

Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.

1988 • 235 citations

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

1990 • 234 citations

Human immunodeficiency virus can infect CD4-negative human fibroblastoid cells.

1989 • 233 citations

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.

1987 • 232 citations

Potent and selective activity of a new carbocyclic nucleoside analog (Carbovir: NSC 614846) against human immunodeficiency virus In vitro

1988 • 229 citations

Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.

1989 • 227 citations

The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides.

1987 • 226 citations

3′-azido-3′-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion.

1987 • 224 citations

Animal models of AIDS

1989 • 219 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin.

1989 • 213 citations

Circulating p24 Antigen Levels and Responses to Dideoxycytidine in Human Immunodeficiency Virus (HIV) Infections

1989 • 211 citations

Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIV

1990 • 211 citations

Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro.

1987 • 210 citations

Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus

1987 • 208 citations

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1990 • 208 citations

Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

1989 • 207 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro.

1987 • 201 citations

Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro

1988 • 194 citations

Suppression of HIV Infection in AZT-Treated SCID-hu Mice

1990 • 193 citations

Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeat.

1988 • 193 citations

Combined Zidovudine and Interferon-α Therapy in Patients with Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)

1989 • 192 citations

Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide

1989 • 190 citations

OSTEOGENESIS IMPERFECTA

1976 • 189 citations

Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor, sulfated polysaccharides extracted from sea algae

1987 • 188 citations

Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 186 citations

Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor

1987 • 184 citations

Differential Effects of nef on HIV Replication: Implications for Viral Pathogenesis in the Host

1989 • 183 citations

Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

1989 • 180 citations

HIV and HCMV coinfect brain cells in patients with AIDS

1988 • 180 citations

Nucleosides. IX. The Formation of 2',3'-Unsaturated Pyrimidine Nucleosides via a Novel β-Elimination Reaction^1,2

1966 • 178 citations

Synthesis and biological activity of several amino analogues of thymidine.

1978 • 176 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay

1987 • 176 citations

Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells.

1989 • 176 citations

SEVERELY DISTURBED ADOLESCENTS

1970 • 172 citations

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

1987 • 167 citations

Synthesis and biological activity of several amino analogs of thymidine

1978 • 165 citations

Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity.

1989 • 162 citations

Functional Analysis of CAR, the Target Sequence for the Rev Protein of HIV-1

1989 • 152 citations

Inhibition of infectivity of human immunodeficiency virus by oxetanocin.

1987 • 150 citations

NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity.

1988 • 148 citations

HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor

1990 • 145 citations

Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease

1990 • 144 citations

Human Immunodeficiency Virus: The Eighth Gene

1987 • 143 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivity

1987 • 142 citations

Oral Dextran Sulfate (UAOO1) in the Treatment of the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1989 • 134 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

Dextran Sulfate Is Poorly Absorbed after Oral Administration

1989 • 133 citations

Potent and selective anti-HTLV-IIILAV activity of 2′,3′-dideoxycytidinene, the 2′,3′-unsaturated derivative of 2′,3′-dideoxycytidine

1986 • 131 citations

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA.

1989 • 129 citations

Effects of 2′,3′‐dideoxynucleosides on mammalian cells and viruses

1984 • 127 citations

Commentary from Westminster

1983 • 126 citations

Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.

1988 • 123 citations

Induction of Endogenous Virus and of Thymidine Kinase by Bromodeoxyuridine in Cell Cultures Transformed by Friend Virus

1974 • 122 citations

HEALTH VISITING AND GENERAL PRACTICE.

1964 • 120 citations

Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogs

1987 • 116 citations

2',3'-Dideoxy-2'-fluoro-ara-a. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV)

1987 • 110 citations

Tumors Arising in Organ Transplant Recipients

1978 • 108 citations

Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells

1989 • 103 citations

Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases

1989 • 100 citations

HUMAN DIPLOID CELL STRAIN RABIES VACCINE

1976 • 99 citations

Dimerization of the tat protein from human immunodeficiency virus: a cysteine-rich peptide mimics the normal metal-linked dimer interface.

1988 • 98 citations

Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

1989 • 93 citations

Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides

1990 • 87 citations

Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity

1988 • 87 citations

Nucleosides. XI. 2',3'-Dideoxycytidine

1967 • 85 citations

Effect of Phosphorothioate Homo-oligodeoxy nucleotides on Herpes Simplex Virus Type 2-induced DNA Polymerase

1989 • 85 citations

Putative Metal Finger Structure of the Human Immunodeficiency Virus Type 1 Enhancer Binding Protein HIV-EP1

1989 • 79 citations

Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro

1990 • 78 citations

Adenallene and cytallene: acyclic-nucleoside analogues that inhibit replication and cytopathic effect of human immunodeficiency virus in vitro.

1988 • 75 citations

Pharmacokinetic Analysis of Dextran Sulfate in Rats as Pertains to Its Clinical Usefulness for Therapy of HIV Infection

1990 • 74 citations

Pediatric AIDS: Problems within Problems

1990 • 72 citations

Three-Drug Synergistic Inhibition of HIV-l Replication In Vitro by Zidovudine, Recombinant Soluble CD4, and Recombinant Interferon-alpha A

1990 • 72 citations

1-(2,3-Anhydro-.beta.-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus

1988 • 71 citations

The National Cancer Institute Phase I Study of 2′,3′-Dideoxyinosine Administration in Adults with AIDS or AIDS-Related Complex: Analysis of Activity and Toxicity Profiles

1990 • 68 citations

Messenger RNA Transport and HIV rev Regulation

1990 • 67 citations

Effect of Interferon on Murine Leukaemia Virus Infection. IV. Formation of Non-infectious Virus in Chronically Infected Cells

1979 • 67 citations

Processing of the structural proteins of human immunodeficiency virus type 1 in the presence of monensin and cerulenin.

1988 • 65 citations

CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses.

1989 • 64 citations

Incorporation of 3’-Azido-3’-deoxythymidine into Cellular DNA and Its Removal in a Human Leukemic Cell Line

1990 • 64 citations

Nucleic acid derived allenols. Unusual analogs of nucleosides with antiretroviral activity

1989 • 64 citations

Tat and Rev

1990 • 64 citations

Synergistic Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication In Vitro by Recombinant Soluble CD4 and 3'-Azido-3'-Deoxythymidine

1989 • 60 citations

Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro.

1990 • 57 citations

Zidovudine Resistance of Human Immunodeficiency Virus

1990 • 55 citations

Overview of the Preclinical Development of an Antiretroviral Drug, 2′,3′-Dideoxyinosine

1990 • 55 citations

Enhancement of HIV Replication and Giant Cell Formation by Tumor Necrosis Factor

1989 • 53 citations

Selective inhibition of human immunodeficiency virus (HIV) by 3′-Azido-2′,3′-dideoxyguanosine invitro

1987 • 52 citations

A second front against AIDS

1989 • 52 citations

Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate

1989 • 50 citations

Phosphate-Methylated DNA Aimed at HIV-1 RNA Loops and Integrated DNA Inhibits Viral Infectivity

1990 • 49 citations

In vitro inhibition of the infectivity and replication of human immunodeficiency virus type 1 by combination of antiretroviral 2',3'-dideoxynucleosides and virus-binding inhibitors

1990 • 49 citations

5-chloro-substituted derivatives of 2',3'-didehydro-2' ,3'-dideoxyuridine, 3'-fluoro-2' ,3'-dideoxyuridine and 3'-azido-2' ,3'-dideoxyuridine as anti-HIV agents

1989 • 41 citations

Inhibition of HIV and virus replication by polysulphated polyxylan

1988 • 40 citations

The Synthesis of 2′,3′-Dideoxyadenosine from 2′-Deoxyadenosine

1964 • 35 citations

Polymer Synthesis in Killed Bacteria: Lethality of 2′,3′-Dideoxyadenosine

1966 • 34 citations

Differences in the interaction of HIV-1 and HIV-2 with CD4.

1990 • 34 citations

Selective Killing of HIV-Infected Cells by Anti-gp120 Immunotoxins

1990 • 26 citations

Inhibition by 2′,3′-dideoxythymidine of retroviral infection of mouse and human cells

1980 • 25 citations

Inhibition of the activity of DNA polymerase α by 2′,3′-dideoxythymidine 5′-triphosphate

1979 • 18 citations