Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

Stereochemically restrained refinement of macromolecular structures

1985 • 614 citations

A structural model for the retroviral proteases

1987 • 594 citations

An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis

1983 • 545 citations

The use of an imaging proportional counter in macromolecular crystallography

1987 • 494 citations

CHEMICAL SYNTHESIS OF PEPTIDES AND PROTEINS

1988 • 484 citations

MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement

1988 • 348 citations

Crystal structure of a retroviral protease proves relationship to aspartic protease family

1989 • 345 citations

Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A.

1988 • 327 citations

Binding of a reduced peptide inhibitor to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action.

1987 • 305 citations

Mechanisms for the removal of benzyl protecting groups in synthetic peptides by trifluoromethanesulfonic acid-trifluoroacetic acid-dimethyl sulfide

1986 • 281 citations

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins

1988 • 269 citations

Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease

1988 • 234 citations

Retroviral protease-like sequence in the yeast transposon Ty 1

1985 • 219 citations

Aspartic proteinases and their inhibitors

1985 • 218 citations

Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease.

1989 • 180 citations

Human immunodeficiency virus protease

1989 • 175 citations

Molecular Modeling of the HIV-1 Protease and Its Substrate Binding Site

1989 • 168 citations

Effective blocking of HIV‐1 proteinase activity by characteristic inhibitors of aspartic proteinases

1989 • 166 citations

Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases

1989 • 140 citations

Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation.

1988 • 127 citations

Partial purification and substrate analysis of bacterially expressed HIV protease by means of monoclonal antibody.

1988 • 115 citations

Constrained-restrained least-squares (CORELS) refinement of proteins and nucleic acids

1985 • 60 citations

A second front against AIDS

1989 • 52 citations

Crystallization of the aspartylprotease from the human immunodeficiency virus, HIV-1

1989 • 37 citations