ClC-2 Cl− channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

Submucosal glands are the predominant site of CFTR expression in the human bronchus

1992 • 644 citations

CFTR Is a Conductance Regulator as well as a Chloride Channel

1999 • 436 citations

Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion

1994 • 341 citations

Sites of Reaction of the Gastric H,K-ATPase with Extracytoplasmic Thiol Reagents

1997 • 258 citations

Heteromultimeric CLC chloride channels with novel properties

1996 • 246 citations

Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland

1999 • 159 citations

Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells

1998 • 147 citations

CFTR in Calu-3 human airway cells: channel properties and role in cAMP-activated Cl- conductance

1994 • 146 citations

CIC-2: a developmentally dependent chloride channel expressed in the fetal lung and downregulated after birth.

1995 • 139 citations

Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel

1995 • 123 citations

Reverse Transcription-Polymerase Chain Reaction (RT-PCR) Phenotypic Analysis of Cell Cultures of Human Tracheal Epithelium, Tracheobronchial Glands, and Lung Carcinomas

1993 • 117 citations

An aspartic acid residue important for voltage-dependent gating of human muscle chloride channels

1995 • 112 citations

A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel

1997 • 108 citations

[44] Cyclic AMP-dependent protein kinase from bovine heart muscle

1974 • 95 citations

Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues

1995 • 94 citations

Subunit Stoichiometry of Human Muscle Chloride Channels

1997 • 94 citations

The mechanism for inhibition of gastric (H+ + K+)-ATPase by omeprazole

1985 • 87 citations

Studies on the mechanism of action of omeprazole

1985 • 73 citations

PKA and arachidonic acid activation of human recombinant ClC-2 chloride channels

2000 • 72 citations

Mechanism of voltage-dependent gating in skeletal muscle chloride channels

1996 • 69 citations

Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.

1998 • 61 citations

Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels

1997 • 61 citations

Comparison of Voltage-activated Cl − Channels in Rat Parotid Acinar Cells with ClC-2 in a Mammalian Expression System

1998 • 58 citations

Cl- channels of the gastric parietal cell that are active at low pH

1993 • 56 citations

The chloride channel ClC‐2 contributes to the inwardly rectifying Cl⁻ conductance in cultured porcine choroid plexus epithelial cells

2000 • 54 citations

ATP counteracts the rundown of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation

1999 • 48 citations

Characterization of the human pH- and PKA-activated ClC-2G(2 alpha) Cl- channel

1997 • 47 citations

The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms

1994 • 45 citations

Omeprazole has a dual mechanism of action: it inhibits both H(+)K(+)ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments).

1999 • 43 citations

Identification of the pH sensor and activation by chemical modification of the ClC-2G Cl⁻ channel

1998 • 41 citations

Inhibition of cystic fibrosis transmembrane conductance regulator chloride channel currents by arachidonic acid

2000 • 40 citations

Inhibition of cystic fibrosis transmembrane conductance regulator chloride channel currents by arachidonic acid

2000 • 33 citations

Keratinocyte Growth Factor Stimulates CLC-2 Expression in Primary Fetal Rat Distal Lung Epithelial Cells

1999 • 28 citations

Perinatal regulation of the ClC-2 chloride channel in lung is mediated by Sp1 and Sp3

1999 • 26 citations

The gastric H,K‐ATPase blocker lansoprazole is an inhibitor of chloride channels

2000 • 15 citations

Intra-atrial communication and control of atrial natriuretic factor (ANF) release

2000 • 14 citations

Mechanism of Inhibition of H+, K+-ATPase by Sodium 2-((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-lH- benzimidazole (E3810).

1996 • 13 citations

Ca²⁺-activated Cl⁻channels Focus on “Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland”

1999 • 11 citations

Activation Of Human Clc‐2 Cl^– Channels: Implications For Cystic Fibrosis

2000 • 10 citations

Inhibitory action of YJA20379, a new proton pump inhibitor onHelicobacter pylori growth and urease

1998 • 7 citations

Possible Role of Ion Channels in the Action of Nonsteroidal Anti-Inflammatory Drugs

2000 • 6 citations

[45] Preparation and properties of cyclic AMP-dependent protein kinases from rabbit red blood cells

1974 • 5 citations

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