Kainic Acid-Mediated Excitotoxicity as a Model for Neurodegeneration

Biological effects of resveratrol

2000 • 1,620 citations

Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology

2000 • 1,555 citations

Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity

2003 • 801 citations

The Role of Excitotoxicity in Neurodegenerative Disease

1999 • 717 citations

Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury

2004 • 635 citations

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

1998 • 575 citations

The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

1997 • 538 citations

Resveratrol protects against global cerebral ischemic injury in gerbils

2002 • 515 citations

Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases.

2003 • 453 citations

Neuropharmacology of AMPA and kainate receptors

1998 • 362 citations

β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism

2000 • 353 citations

Phospholipase A₂ and Its Role in Brain Tissue

1997 • 337 citations

Up-Regulated Production and Activation of the Complement System in Alzheimer's Disease Brain

1999 • 325 citations

The “French paradox” and beyond: neuroprotective effects of polyphenols1,2 1Guest editor: Arthur Cederbaum 2This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury.” The full list of papers may be found on the homepage of the journal.

2002 • 325 citations

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons

2000 • 302 citations

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

2000 • 300 citations

Effects of resveratrol on the rat brain respiratory chain.

1999 • 256 citations

Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

2000 • 246 citations

Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

1997 • 216 citations

Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells

2001 • 211 citations

Pathophysiology of perinatal brain damage

1999 • 207 citations

Resveratrol inhibition of lipid peroxidation

2000 • 204 citations

Oxidative stress and neurodegenerative disorders

1998 • 203 citations

Biochemical Diagnosis of Alzheimer Disease by Measuring the Cerebrospinal Fluid Ratio of Phosphorylated tau Protein to β-Amyloid Peptide42

2003 • 192 citations

Nitric Oxide, Mitochondria, and Cell Death

2001 • 174 citations

Astrocytes as mediators of immune and inflammatory responses in the CNS.

1998 • 169 citations

Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury

2002 • 151 citations

Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death

2000 • 141 citations

Agrin Is a Major Heparan Sulfate Proteoglycan Accumulating in Alzheimer's Disease Brain

1999 • 129 citations

Ethanol and oxidative mechanisms in the brain

2001 • 127 citations

Neurochemical consequences of kainate-induced toxicity in brain: involvement of arachidonic acid release and prevention of toxicity by phospholipase A2 inhibitors

2001 • 126 citations

CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy

2000 • 125 citations

Resveratrol Protects Against Neurotoxicity Induced by Kainic Acid

2004 • 122 citations

Role of PKC and MAPK in cytosolic PLA₂ phosphorylation and arachadonic acid release in primary murine astrocytes

2002 • 119 citations

Ethanol-induced cell death by lipid peroxidation in PC12 cells.

1997 • 114 citations

Nitric oxide synthase induction in astroglial cell cultures: Effect on heat shock protein 70 synthesis and oxidant/antioxidant balance

2000 • 110 citations

Excitotoxins, Aging, and Environmental Neurotoxins: Implications for Understanding Human Neurodegenerative Diseases

1995 • 109 citations

Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain

2002 • 109 citations

Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease

1998 • 104 citations

Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons

1994 • 103 citations

Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment

1999 • 103 citations

Protective Effect Of Resveratrol On Oxidative Damage In Male And Female Stroke‐Prone Spontaneously Hypertensive Rats

2001 • 100 citations

Ethanol and Oxidative Stress

2001 • 99 citations

Microglial activation and increased synthesis of complement component C1q precedes blood–brain barrier dysfunction in rats

2003 • 98 citations

Inflammatory Activation of Human Brain Endothelial Cells by Hypoxic Astrocytes In Vitro is Mediated by IL-1β

2000 • 98 citations

Heparan sulfate proteoglycan expression in cerebrovascular amyloid β deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains

2001 • 95 citations

The biochemical mechanisms of the excitotoxicity of Kainic acid

1992 • 95 citations

Age dependence of seizure-induced oxidative stress

2003 • 94 citations

Dendritic localization of Ca2+-permeable AMPA/kainate channels in hippocampal pyramidal neurons

1999 • 87 citations

Mechanisms of cell death in neurodegenerative disorders

2000 • 82 citations

Different effects of genistein and resveratrol on oxidative DNA damage in vitro

2002 • 81 citations

Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse

2002 • 80 citations

Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices

1993 • 80 citations

Oxidant-mediated AA release from astrocytes involves cPLA2 and iPLA2

2003 • 75 citations

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration

1999 • 74 citations

Oxidized lipoproteins activate NF-κB binding activity and apoptosis in PC12 cells

1998 • 73 citations

Changes in Nitric Oxide Synthesis and Epileptic Activity in the Contralateral Hippocampus of Rats Following Intrahippocampal Kainate Injection

2001 • 71 citations

Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques

2002 • 68 citations

Modulation of Cell Death by Mouse Genotype: Differential Vulnerability to Excitatory Amino Acid-Induced Lesions

2002 • 68 citations

Selective vulnerability to kainate‐induced oxidative damage in different rat brain regions

2001 • 67 citations

Neuronal localization of C1q in preclinical Alzheimer's disease

2003 • 67 citations

Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status epilepticus but prior to cell loss

1998 • 61 citations

Cytokine Induction of iNOS and sPLA2 in Immortalized Astrocytes (DITNC): Response to Genistein and Pyrrolidine Dithiocarbamate

1999 • 56 citations

Kainate receptors in hippocampal CA3 subregion: evidence for a role in regulating neurotransmitter release

1998 • 55 citations

Dietary vitamin E and physical exercise: II. Antioxidant status and lipofuscin-like substances in aging rat heart

2003 • 53 citations

Heterogeneity of Ca²⁺-Permeable AMPA/Kainate Channel Expression in Hippocampal Pyramidal Neurons: Fluorescence Imaging and Immunocytochemical Assessment

2003 • 51 citations

Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment

2002 • 47 citations

Distinct involvement of NF‐κB and p38 mitogen‐activated protein kinase pathways in serum deprivation‐mediated stimulation of inducible nitric oxide synthase and its inhibition by 4‐hydroxynonenal

2001 • 46 citations

Nuclear factor κB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca2+ channel following severe global ischemia in rat hippocampus

2002 • 46 citations

Kainic Acid: Insights into Excitatory Mechanisms Causing Selective Neuronal Degeneration

2007 • 44 citations

Kainic Acid and Decorticating Lesions Stimulate the Synthesis of C1q Protein in Adult Rat Brain

1997 • 43 citations

Glutamate toxicity enhances tau gene expression in neuronal cultures

1997 • 42 citations

The effects of excitotoxicity on the expression of the amyloid precursor protein gene in the brain and its modulation by neuroprotective agents

1998 • 36 citations

The effect of neuroleptic treatment and of high dosage diazepam therapy onβ-endorphin immunoreactivity in plasma of schizophrenic patients

1984 • 34 citations

Complement C1q expression induced by Aβ in rat hippocampal organotypic slice cultures

2003 • 33 citations

In situ nick end-labeling detects necrosis of hippocampal pyramidal cells induced by kainic acid

1996 • 32 citations

Neuroprotection Abilities of Cytosolic Phospholipase A2 Inhibitors in Kainic acid-induced Neurodegeneration

2004 • 29 citations

Dual role of glutamatergic neurotransmission on amyloid β1–42 aggregation and neurotoxicity in embryonic avian retina

2001 • 28 citations

Secreted phospholipase A2-induced neurotoxicity and epileptic seizures after intracerebral administration: An unexplained heterogeneity as emphasized with paradoxin and crotoxin

1998 • 26 citations

In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons

2002 • 25 citations

Leupeptin Causes an Accumulation of Lipofuscin‐Like Substances and Other Signs of Aging in Kidneys of Young Rats: Further Evidence for the Protease Inhibitor Model of Aginga

1996 • 24 citations

Inhibition of C1q-$beta;-amyloid binding protects hippocampal cells against complement mediated toxicity

2003 • 24 citations

Neuronal apoptosis is associated with a decrease in tau mRNA expression

1998 • 24 citations

Distribution of perlecan in mouse hippocampus following intracerebroventricular kainate injections

1998 • 22 citations

Local injection of kainic acid causes widespread degeneration of NADPH-d neurons and induction of NADPH-d in neurons, endothelial cells and reactive astrocytes

1996 • 22 citations

Down-regulation of GluR2 is associated with Ca2+-dependent protease activities in kainate-induced apoptotic cell death in culturd rat hippocampal neurons

2003 • 21 citations

TOXIC NEURONAL APOPTOSIS AND MODIFICATIONS OF TAU AND APP GENE AND PROTEIN EXPRESSIONS*

1999 • 20 citations

Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC).

2000 • 20 citations

Markers of apoptosis and models of programmed cell death in Alzheimer’s disease

2000 • 19 citations

Chapter 23: Kainic acid-induced excitotoxicity in neurons and glial cells

1992 • 17 citations

The Distribution of β-Amyloid Precursor Protein in Rat Cortex after Systemic Kainate-Induced Seizures

1997 • 17 citations

Kainate exacerbates β-amyloid toxicity in rat hippocampus

2003 • 8 citations

Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates.

2003 • 7 citations

Reduced susceptibility to Kainic Acid-induced excitoxicity in T-cell deficient CD4/CD8(−/−) and middle-aged C57BL/6 mice

2003 • 7 citations

Distribution of amyloid beta-protein immunoreactivity in the hippocampus of rats injected with kainate.

1997 • 1 citations