Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status epilepticus but prior to cell loss

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1979 • 54,907 citations

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Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

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1991 • 1,458 citations

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

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2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody

1994 • 860 citations

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

1996 • 835 citations

Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels

1991 • 827 citations

Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism

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Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

Kainic acid seizures in the rat

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Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

Kainic acid as a tool for the study of temporal lobe epilepsy

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Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient GluR-B Allele in Mice

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1990 • 555 citations

Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

1990 • 498 citations

Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons

1992 • 416 citations

Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells

1992 • 413 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration

1993 • 396 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure

1989 • 355 citations

Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain

1989 • 330 citations

Acute dendrotoxic changes in the hippocampus of kainate treated rats

1979 • 306 citations

Selective neuronal death after transient forebrain ischemia in the mongolian gerbil: A silver impregnation study

1988 • 298 citations

Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors.

1992 • 284 citations

Fractional contribution of calcium to the cation current through glutamate receptor channels

1993 • 281 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study

1994 • 271 citations

Evidence suggesting secondary epileptogenic lesions after kainic acid: pretreatment with diazepam reduces distant but not local brain damage

1979 • 249 citations

Biochemical Characterization and Localization of a Non‐N‐Methyl‐D‐Aspartate Glutamate Receptor in Rat Brain

1992 • 242 citations

A Reliable and Sensitive Method to Localize Terminal Degeneration and Lysosomes in the Central Nervous System

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Heterogeneity of synaptic glutamate receptors on CA3 stratum radiatum interneurones of rat hippocampus.

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Ca(2+)‐permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus.

1995 • 225 citations

Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo

1993 • 216 citations

Instantaneous Perturbation of Dentate Interneuronal Networks by a Pressure Wave-Transient Delivered to the Neocortex

1997 • 201 citations

Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia

1993 • 196 citations

Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: Comparison with the mRNA for the D₂ receptor, tyrosine hydroxylase and calbindin immunoreactivity

1995 • 195 citations

The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain

1991 • 189 citations

Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity

1996 • 188 citations

AMPA receptors in the rat and primate hippocampus: a possible absence of GLUR2/3 subunits in most interneurons

1996 • 180 citations

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

1995 • 171 citations

Regulation of Ca++ influx into striatal neurons by kainic acid.

1989 • 162 citations

Ca²⁺-Permeable AMPA/Kainate and NMDA Channels: High Rate of Ca²⁺Influx Underlies Potent Induction of Injury

1996 • 156 citations

Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey

1993 • 146 citations

Changes in intracellular pH associated with glutamate excitotoxicity

1993 • 144 citations

The Cerebral Microvessels in Culture, an Update

1992 • 144 citations

Blockade of both NMDA and non-NMDA receptors is required for optimal protection against ischemic neuronal degeneration in the in vivo adult mammalian retina

1991 • 142 citations

AMPA receptors with high Ca2+ permeability mediate synaptic transmission in the avian auditory pathway.

1995 • 140 citations

Secondary Ca2+ overload indicates early neuronal injury which precedes staining with viability indicators

1993 • 135 citations

The role of brain edema in epileptic brain damage induced by systemic kainic acid injection

1984 • 134 citations

Distribution of the excitatory amino acid receptor subunits GluR2(4) in monkey hippocampus and colocalization with subunits GluR5-7 and NMDAR1

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Synaptic Distribution of the AMPA-GluR2 Subunit and Its Colocalization with Calcium-Binding Proteins in Rat Cerebral Cortex: An Immunohistochemical Study Using a GluR2-Specific Monoclonal Antibody

1996 • 116 citations

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

1991 • 110 citations

Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures

1992 • 109 citations

Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy

1994 • 104 citations

Selective neuronal vulnerability in the hippocampus — a role for gene expression?

1995 • 102 citations

Down‐Regulation of AMPA Receptor Subunit GluR2 in Amygdaloid Kindling

1995 • 88 citations

Enkephalin biosynthesis and enkephalin gene expression are increased in hippocampal mossy fibers following a unilateral lesion of the hilus

1987 • 86 citations

Cerebral Blood Flow, Metabolism and Epilepsy

1986 • 86 citations

Systemic administration of kainic acid differentially regulates the levels of prodynorphin and proenkephalin mRNA and peptides in the rat hippocampus

1991 • 78 citations

Fractional calcium current through neuronal AMPA-receptor channels with a low calcium permeability

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Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons.

1995 • 73 citations

Long-term observation of rats after unilateral intra-amygdaloid injection of kainic acid

1988 • 61 citations

Suppression of programmed neuronal death by a thapsigargin‐induced Ca²⁺ influx

1995 • 58 citations

Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus

1991 • 57 citations

Developmental Regulation of Glutamate and GABA<sub>A</sub> Receptor Gene Expression in Rat Hippocampus following Kainate-Induced Status epilepticus

1997 • 57 citations

Excitatory and inhibitory synaptic currents and receptors in rat medial septal neurones.

1992 • 49 citations

Elevated Intracellular Calcium Blocks Programmed Neuronal Death

1994 • 45 citations

Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain

1994 • 44 citations

Changes in glutamate receptor and proenkephalin gene expression after kindled seizures

1994 • 43 citations

Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR 5/6/7 in the human epileptogenic neocortex

1994 • 43 citations

Seizures induce tenascin-C mRNA expression in neurons

1996 • 39 citations

Neuronal death, a tradition of dying

1992 • 38 citations

Unchanged balance between levels of mRNA encoding AMPA glutamate receptor subtypes following global cerebral ischemia in the rat.

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Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats

1996 • 33 citations

In situ nick end-labeling detects necrosis of hippocampal pyramidal cells induced by kainic acid

1996 • 32 citations

Hypoxia prevents seizures and neuronal damages of the hippocampus induced by kainic acid in rats

1990 • 28 citations

Combined kainate and ischemia produces ‘mesial temporal sclerosis’

1990 • 28 citations

NBQX prevents contralateral but not ipsilateral seizure-induced cytotoxicity of kainate but not AMPA-reversal at high doses of NBQX

1994 • 8 citations