Ethanol and oxidative mechanisms in the brain

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Wine, alcohol, platelets, and the French paradox for coronary heart disease

1992 • 3,600 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids

1995 • 2,134 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine

1993 • 1,665 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

1997 • 1,018 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Properties and Regulation of Cytosolic Phospholipase A2

1997 • 814 citations

Concentration of the Phytoalexin Resveratrol in Wine

1992 • 711 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Regulatory Functions of Phospholipase A2

1997 • 551 citations

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1992 • 484 citations

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1998 • 455 citations

The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach

1998 • 352 citations

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease

1997 • 350 citations

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1998 • 313 citations

Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

1989 • 298 citations

Risk factors for late‐ onset Alzheimer's disease: A population‐ based, case‐control study

1993 • 289 citations

Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression

1991 • 253 citations

Effects of stilbene components of the roots of Polygonum cuspidatum Sieb. et Zucc. on lipid metabolism.

1982 • 251 citations

Phospholipase A(2)s in cell injury and death.

2000 • 244 citations

Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro.

1987 • 242 citations

Ethanol Increases Cytochrome P4502E1 and Induces Oxidative Stress in Astrocytes

1995 • 218 citations

Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

1997 • 216 citations

Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain

1996 • 211 citations

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system

1990 • 202 citations

NITRIC OXIDE ACTIONS IN NEUROCHEMISTRY

1996 • 184 citations

Hydroxyl Radical Formation from Cuprous Ion and Hydrogen Peroxide: A Spin-Trapping Study

1995 • 182 citations

β-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

1996 • 168 citations

Peroxynitrite‐Induced Alterations in Synaptosomal Membrane Proteins

1999 • 165 citations

Plasticity of astrocytes

1994 • 165 citations

In vivo formation of a free radical metabolite of ethanol.

1990 • 164 citations

Patterns of neuronal loss in the cerebral cortex in chronic alcoholic patients

1989 • 154 citations

Chronic Ethanol IncreasesN-Methyl-d-Aspartate-Stimulated Nitric Oxide Formation but Not Receptor Density in Cultured Cortical Neurons

1997 • 135 citations

Inhibition of lipopolysaccharide-mediated NFκB activation by ethanol in human monocytes

1999 • 133 citations

Amyloid β-peptide and oxidative cellular injury in Alzheimer’s disease

1996 • 132 citations

Relation of Smoking and Alcohol Consumption to Incident Alzheimer's Disease

1992 • 127 citations

Induction of Cyclooxygenase‐2 in Brain During Acute and Chronic Ethanol Treatment and Ethanol Withdrawal

1999 • 124 citations

Effect of ethanol on cytochrome P450 in the rat brain.

1994 • 123 citations

Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells.

1995 • 122 citations

Brain iNOS: current understanding and clinical implications

1999 • 119 citations

Ethanol-induced cell death by lipid peroxidation in PC12 cells.

1997 • 114 citations

Isoflavonoid Compounds Extracted from Pueraria lobata Suppress Alcohol Preference in a Pharmacogenetic Rat Model of Alcoholism

1996 • 112 citations

Genes encoding multiple forms of phospholipase A2 are expressed in rat brain

1998 • 108 citations

Peroxynitrite Induces Tyrosine Nitration and Modulates Tyrosine Phosphorylation of Synaptic Proteins

1999 • 102 citations

Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids

1988 • 100 citations

trans‐Resveratrol Protects Embryonic Mesencephalic Cells from tert‐Butyl Hydroperoxide

2000 • 91 citations

Involvement of phospholipase A2 in neurodegeneration

1997 • 87 citations

β‐Amyloid Peptide Interacts Specifically with the Carboxyl‐Terminal Domain of Human Apolipoprotein E

1999 • 86 citations

Role of antioxidant nutrients in aging: Overview

1995 • 84 citations

Spin-trapping studies of hepatic free radicals formed following the acute administration of ethanol to rats: In vivo detection of 1-hydroxyethyl radicals with PBN

1991 • 81 citations

Chronic Alcohol Administration Stimulates Nitric Oxide Formation in the Rat Liver With or Without Pretreatment by Lipopolysaccharide

1995 • 79 citations

Oxidized lipoproteins activate NF-κB binding activity and apoptosis in PC12 cells

1998 • 73 citations

Dietary supplementation of grape polyphenols and chronic ethanol administration on LDL oxidation and platelet function in rats

1998 • 70 citations

Temporal Relations Among Amyloid β-Peptide-Induced Free-Radical Oxidative Stress, Neuronal Toxicity, and Neuronal Defensive Responses

1998 • 61 citations

Cytokine Induction of iNOS and sPLA2 in Immortalized Astrocytes (DITNC): Response to Genistein and Pyrrolidine Dithiocarbamate

1999 • 56 citations

Effect of chronic ethanol exposure on mouse brain arachidonic acid specific phospholipase A2

1998 • 55 citations

■ REVIEW : Glial NO: Normal and Pathological Roles

1996 • 54 citations

Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration

1999 • 51 citations

Phospholipases as mediators of amyloid beta peptide neurotoxicity: an early event contributing to neurodegeneration characteristic of Alzheimer's disease

1998 • 44 citations

Suppression by ethanol of inducible nitric oxide synthase expression in C6 glioma cells.

1997 • 43 citations

Amyloid β-peptide(1–40)-mediated oxidative stress in cultured hippocampal neurons

1998 • 43 citations

Ethanol Inhibition of Inducible Nitric Oxide Synthase Activity in C₆ Glioma Cells

1995 • 43 citations

Role of cytochrome P-450 in the stimulation of microsomal production of reactive oxygen species by ferritin

1996 • 41 citations

The Intracellular Signaling Network as a Target for Ethanol

1998 • 39 citations

Alcohol and Nitric Oxide Production by Cells of the Brain

1998 • 38 citations

Ganglioside GM1 reduces ethanol induced phospholipase A2 activity in synaptosomal preparations from mice

1994 • 38 citations

1-Hydroxyethyl radical formation during NADPH- and NADH-dependent oxidation of ethanol by human liver microsomes.

1996 • 37 citations

Ethanol potentiates interleukin-1 β-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells

1995 • 36 citations

Chronic Ethanol and Iron Administration on Iron Content, Neuronal Nitric Oxide Synthase, and Superoxide Dismutase in Rat Cerebellum

1999 • 34 citations

Mechanism of amyloid β protein induced neuronal cell death: current concepts and future perspectives

1997 • 33 citations

Stimulation of group II phospholipase A2 mRNA expression and release in an immortalized astrocyte cell line (DITNC) by LPS, TNFα, and IL-1β

1995 • 32 citations

Dietary Supplementation of Grape Polyphenols to Rats Ameliorates Chronic Ethanol-Induced Changes in Hepatic Morphology without Altering Changes in Hepatic Lipids

1999 • 32 citations

Ethanol potentiates lipopolysaccharide- or interleukin-1 β-induced nitric oxide generation in RBE4 cells

1996 • 31 citations

REGULATION OF RAT NEURONAL NITRIC OXIDE SYNTHASE ACTIVITY BY CHRONIC ALCOHOLIZATION

1997 • 30 citations

Alzheimer's disease and alcoholism: Possible interactions

1992 • 25 citations

Ethanol inhibits cytokine-induced iNOS and sPLA2 in immortalized astrocytes: Evidence for posttranscriptional site of ethanol action

2001 • 24 citations

Oxidized lipoproteins, beta amyloid peptides and alzheimer’s disease

2001 • 24 citations

Potentiation of ethanol-induced lipid peroxidation of biological membranes by vitamin C

1988 • 22 citations

Interaction of Ferric Complexes with NADH–Cytochrome b5 Reductase and Cytochrome b5: Lipid Peroxidation, H2O2Generation, and Ferric Reduction

1996 • 22 citations

The involvement of ethanol in the free radical reaction of 6-hydroxydopamine

1991 • 20 citations

Studies on the cytosolic phospholipase A2 in immortalized astrocytes (DITNC) revealed new properties of the calcium ionophore, A23187.

1999 • 20 citations

Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC).

2000 • 20 citations

Induction of Cyclooxygenase-2 in Brain During Acute and Chronic Ethanol Treatment and Ethanol Withdrawal

1999 • 18 citations

The Potential Mechanism of Induction of Inducible Nitric Oxide Synthase mRNA in Alveolar Macrophages by Lipopolysaccharide and Its Suppression by Ethanol, In Vivo

1998 • 14 citations

The role of prostaglandin synthetase in the rate depressant effects and narcosis caused by ethanol.

1991 • 12 citations

The role of specific eicosanoids in mediating the acute narcotic effects of ethanol.

1996 • 10 citations

Spin Trapping Studies of the Influence of Alcohol on Lipid Peroxidation

1989 • 8 citations

Development of glial cells cultured from prenatally alcohol treated rat brain: Effect of supplementation of the maternal alcohol diet with a grape extract

1996 • 7 citations

Effect of ethanol on expression of nitric oxide synthases in the cerebral culture cells from chick embryo.

1996 • 6 citations

Mechanism of amyloid β protein induced neuronal cell death: current concepts and future perspectives

1997 • 6 citations

Prostaglandin involvement in ethanol's mechanism of action.

1987 • 5 citations

Atypical SCH23390 binding sites are present on bovine adrenal medullary membranes.

2000 • 5 citations

Neurotoxicity and substance abuse: Further fuel for regulatory dilemma

2001 • 4 citations

Chronic Ethanol and Iron Administration on Iron Content, Neuronal Nitric Oxide Synthase, and Superoxide Dismutase in Rat Cerebellum

1999 • 3 citations