Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood–brain barrier

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Mammalian ABC Transporters in Health and Disease

2002 • 1,531 citations

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

2004 • 1,329 citations

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

2012 • 1,196 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

Drug resistance in brain diseases and the role of drug efflux transporters

2005 • 848 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

The multidrug resistance protein family

1999 • 654 citations

Neurotrophic and Neuroprotective Actions of Estrogens and Their Therapeutic Implications

2001 • 537 citations

Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations.

2001 • 537 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

MDR1 Gene Expression in Brain of Patients with Medically Intractable Epilepsy

1995 • 525 citations

Aquaporin-4 in the central nervous system: Cellular and subcellular distribution and coexpression with KIR4.1

2004 • 485 citations

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

2002 • 479 citations

(Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) The MRP-Related and BCRP / ABCG2 Multidrug Resistance Proteins: Biology, Substrate Specificity and Regulation

2004 • 477 citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

2000 • 473 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs

2002 • 409 citations

Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain

2004 • 369 citations

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

2000 • 358 citations

Xenobiotic Transport across Isolated Brain Microvessels Studied by Confocal Microscopy

2000 • 310 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

2000 • 233 citations

Multidrug Resistance Protein MRP2 Contributes to Blood-Brain Barrier Function and Restricts Antiepileptic Drug Activity

2003 • 232 citations

Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats

2002 • 211 citations

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

2000 • 206 citations

Multidrug resistance and the role of P-glycoprotein knockout mice

1995 • 199 citations

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors

2003 • 198 citations

Expression and Cellular Distribution of Multidrug Resistance–related Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy

2004 • 195 citations

Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine

2002 • 167 citations

CONSTITUTIVE EXPRESSION OF VARIOUS XENOBIOTIC AND ENDOBIOTIC TRANSPORTER mRNAs IN THE CHOROID PLEXUS OF RATS

2003 • 161 citations

Potential role of ABC transporters as a detoxification system at the blood?CSF barrier

2004 • 157 citations

Tissue distribution of the human MDR3 P-glycoprotein.

1994 • 153 citations

Mechanisms of antiepileptic drug resistance

2003 • 152 citations

Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood–brain barrier

2004 • 146 citations

Mechanisms of antiepileptic drug resistance

2003 • 141 citations

Multidrug Resistance‐Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates

1998 • 139 citations

Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones

2002 • 133 citations

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures

2003 • 127 citations

Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

2000 • 115 citations

Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

2002 • 106 citations

Isolation of Endothelial Cells from Brain, Lung, and Kidney: Expression of the Multidrug Resistance P-Glycoprotein Isoforms

2001 • 104 citations

Organic anion transport across the choroid plexus

2000 • 91 citations

C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins

2003 • 90 citations

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

1999 • 76 citations

The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCS) in the choroid plexus and microvasculature of the brain

2004 • 68 citations

Differential expression of utrophin and dystrophin in CNS neurons: An in situ hybridization and immunohistochemical study

2000 • 64 citations

Brain Access and Anticonvulsant Efficacy of Carbamazepine, Lamotrigine, and Felbamate in ABCC2/MRP2‐Deficient TR⁻ Rats

2003 • 62 citations

Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy.

2004 • 61 citations

Identification of the Apical Membrane-targeting Signal of the Multidrug Resistance-associated Protein 2 (MRP2/cMOAT)

2001 • 55 citations

Widespread Upregulation of Drug‐resistance Proteins in Fatal Human Status Epilepticus

2003 • 54 citations