Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood–brain barrier

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Astrocytes induce blood–brain barrier properties in endothelial cells

1987 • 1,593 citations

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

1997 • 889 citations

Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord

1998 • 593 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

1990 • 534 citations

Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells

1980 • 389 citations

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

1999 • 362 citations

Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model

1987 • 353 citations

In vitro model for evaluating drug transport across the blood–brain barrier

1999 • 349 citations

Role of the CNS microvascular pericyte in the blood-brain barrier

1998 • 301 citations

Drug Transfer Across the Blood‐Brain Barrier: Correlation Between In Vitro and In Vivo Models

1992 • 289 citations

Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes

1997 • 266 citations

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

1997 • 249 citations

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

2000 • 233 citations

Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes.

1994 • 223 citations

Bovine Brain Endothelial Cells Express Tight Junctions and Monoamine Oxidase Activity in Long‐Term Culture

1989 • 210 citations

Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers.

1999 • 204 citations

Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

1998 • 202 citations

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

2001 • 176 citations

Functional expression of p-glycoprotein and multidrug resistance-associated protein (mrp1) in primary cultures of rat astrocytes

2000 • 156 citations

Brain Microvascular and Astrocyte Localization of P‐Glycoprotein

1997 • 146 citations

Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones

2002 • 133 citations

Neurons and ECM regulate occludin localization in brain endothelial cells

2000 • 122 citations

A co-culture-based model of human blood–brain barrier: application to active transport of indinavir and in vivo–in vitro correlation

2002 • 115 citations

Endothelin-1 as a Mediator of Endothelial Cell–Pericyte Interactions in Bovine Brain Capillaries

1997 • 107 citations

Isolation of Endothelial Cells from Brain, Lung, and Kidney: Expression of the Multidrug Resistance P-Glycoprotein Isoforms

2001 • 104 citations

Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture

2003 • 88 citations

Functional expression of P-glycoprotein in rat brain microglia.

2001 • 86 citations

Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human Epilepsy

2003 • 81 citations

Multidrug resistance-associated protein: A protein distinct from P-glycoprotein involved in cytotoxic drug expulsion

1997 • 78 citations

Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.

1998 • 77 citations

Differentiation of Brain Endothelial Cells in Cell Culture

1991 • 67 citations

Protective effect of glial cells against lipopolysaccharide‐mediated blood‐brain barrier injury

2003 • 60 citations

P-glycoprotein and caveolin-1α in endothelium and astrocytes of primate brain

2003 • 57 citations

Regulation of a Blood-Brain Barrier—Specific Enzyme Expressed by Cerebral Pericytes (Pericytic Aminopeptidase N/pAPN) under Cell Culture Conditions

1998 • 36 citations

[Transport of glutathione].

1988 • 14 citations