Molecular cloning, expression and characterization of the human serine/threonine kinase Akt‐3

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Integrins and anoikis

1997 • 1,145 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

1997 • 718 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

1999 • 470 citations

Modes of DAPI banding and simultaneous in situ hybridization

1993 • 397 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Activated Phosphatidylinositol 3-Kinase and Akt Kinase Promote Survival of Superior Cervical Neurons

1997 • 245 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity

1992 • 217 citations

A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain

1999 • 198 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

Molecular Cloning and Characterization of a New Member of the RAC Protein Kinase Family: Association of the Pleckstrin Homology Domain of 3 Types of RAC Protein Kinase with Protein Kinase C Subspecies and βγ Subunits of G Proteins

1995 • 189 citations

Identification of a Human Akt3 (Protein Kinase B γ) Which Contains the Regulatory Serine Phosphorylation Site

1999 • 184 citations

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

1993 • 173 citations

Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

1995 • 101 citations

Molecular Cloning of Rat RAC Protein Kinase α and β and Their Association with Protein Kinase Cζ

1994 • 71 citations

Molecular cloning, expression and tissue distribution of glial‐cell‐line‐derived neurotrophic factor family receptor α‐3 (GFRα‐3)

1998 • 68 citations

A Surprising Function for the PTEN Tumor Suppressor

1998 • 41 citations