Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Origin, maturation and antigen presenting function of dendritic cells

1997 • 1,375 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Induction of Immunological Tolerance by Porcine Liver Allografts

1969 • 826 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

2000 • 723 citations

Local control of the immune response in the liver

2000 • 593 citations

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

1999 • 586 citations

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

1997 • 493 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

2001 • 351 citations

Scavenger functions of the liver endothelial cell

1990 • 324 citations

Structure and Function of Sinusoidal Lining Cells in the Liver

1996 • 293 citations

The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo

1994 • 291 citations

Induction of cytokine production in naive CD4+ T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells☆, ☆☆

1999 • 288 citations

Hepatic Suppression of Sensitization to Antigen absorbed into the Portal System

1967 • 253 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells

1996 • 213 citations

Passage of Undegraded Dietary Antigen into the Blood of Healthy Adults

1985 • 203 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

ANTIBODIES TO INTESTINAL MICROBES IN SERUM OF PATIENTS WITH CIRRHOSIS OF THE LIVER

1972 • 191 citations

Expression patterns of leukocyte adhesion ligand molecules on human liver endothelia. Lack of ELAM-1 and CD62 inducibility on sinusoidal endothelia and distinct distribution of VCAM-1, ICAM-1, ICAM-2, and LFA-3.

1993 • 189 citations

Endotoxin Down-Regulates T Cell Activation by Antigen-Presenting Liver Sinusoidal Endothelial Cells

1999 • 181 citations

Are dendritic cells the key to liver transplant tolerance?

1999 • 180 citations

Endothelial Cell Phenotypic Diversity: In Situ Demonstration of Immunologic and Enzymatic Heterogeneity that Correlates with Specific Morphologic Subtypes

1987 • 149 citations

Dendritic Cell Immunization Breaks Cytotoxic T Lymphocyte Tolerance in Hepatitis B Virus Transgenic Mice

1998 • 147 citations

Extremely rapid endocytosis mediated by the mannose receptor of sinusoidal endothelial rat liver cells

1989 • 145 citations

The essential roles of parenchymal tissues and passenger leukocytes in the tolerance induced by liver grafting in rats

1995 • 138 citations

Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases

1997 • 137 citations

Failure to induce organ-specific autoimmunity by breaking of tolerance: importance of the microenvironment

1998 • 131 citations

Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells.

1996 • 127 citations

In situ immunophenotyping study of endothelial cells of the human hepatic sinusoid: Results and functional implications

1991 • 125 citations

Intermittence of blood flow in liver sinusoids, studied by high-resolution in vivo microscopy

1995 • 121 citations

CTL access to tissue antigen is restricted in vivo.

1994 • 120 citations

Vascular adhesion protein 1 mediates binding of T cells to human hepatic endothelium

1996 • 119 citations

Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction

1994 • 117 citations

A comparison of the antigen‐presenting capabilities of class II MHC‐expressing human lung epithelial and endothelial cells

1997 • 114 citations

Characteristics of virus-specific CD8⁺T cells in the liver during the control and resolution phases of influenza pneumonia

1998 • 109 citations

Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells

1998 • 102 citations

Human Vascular Endothelial Cells Stimulate Memory But Not Naive CD8+ T Cells to Differentiate into CTL Retaining an Early Activation Phenotype

2000 • 101 citations

Passage of Undegraded Dietary Antigen into the Blood of Healthy Adults Further Characterization of the Kinetics of Uptake and the Size Distribution of the Antigen

1986 • 98 citations

PROLONGATION OF RAT SMALL BOWEL OR RENAL ALLOGRAFT SURVIVAL BY PRETRANSPLANT TRANSFUSION AND/OR BY VARYING THE ROUTE OF ALLOGRAFT VENOUS DRAINAGE

1994 • 87 citations

Kupffer cell blockade inhibits induction of tolerance by the portal venous route.

1989 • 87 citations

KUPFFER CELL BLOCKADE INHIBITS INDUCTION OF TOLERANCE BY THE PORTAL VENOUS ROUTE

1989 • 85 citations

Enhanced Expression of CD80 (B7-1), CD86 (B7-2), and CD40 and Their Ligands CD28 and CD154 in Fulminant Hepatic Failure

1999 • 80 citations

Liver sinusoidal lining cells express class II major histocompatibility antigens but are poor stimulators of fresh allogeneic T lymphocytes.

1986 • 78 citations

Evidence That an OX-2-Positive Cell Can Inhibit the Stimulation of Type 1 Cytokine Production by Bone Marrow-Derived B7-1 (and B7-2)-Positive Dendritic Cells

1999 • 78 citations

The cell adhesion molecules of hepatic sinusoidal endothelial cells

1994 • 78 citations

Both macrophages and endothelial cells of the human hepatic sinusoid express the CD4 molecule, a receptor for the human immunodeficiency virus

1990 • 68 citations

Distribution of the major histocompatibility complex antigens on different cellular components of human liver

1984 • 63 citations

Fc receptors of liver sinusoidal endothelium in normal rats and humans

1987 • 52 citations

Major histocompatibility complex antigens in human liver transplants

1990 • 49 citations

Major histocompatibility complex class II–dependent antigen presentation by human intestinal endothelial cells

1998 • 47 citations

Mouse Vascular Adhesion Protein 1 Is a Sialoglycoprotein with Enzymatic Activity and Is Induced in Diabetic Insulitis

1999 • 45 citations

Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.

1994 • 29 citations

Fc receptors of liver sinusoidal endothelium in normal rats and humans

1987 • 19 citations

6 Immunopathogenesis of viral hepatitis

1996 • 15 citations

Visualization of the uptake and processing of oxidized low-density lipoproteins in human and rat liver

1993 • 11 citations

Cluster mannosides can inhibit mannose receptor-mediated tissue-type plasminogen activator degradation by both rat and human cells.

1997 • 10 citations

Cluster mannosides can inhibit mannose receptor-mediated tissue-type plasminogen activator degradation by both rat and human cells

1997 • 2 citations