Alcohol and Oxidative Liver Injury

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Cytochrome P-4502E1: its physiological and pathological role

1997 • 881 citations

Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

1999 • 704 citations

Role of CYP2E1 in the Hepatotoxicity of Acetaminophen

1996 • 641 citations

Implication of free radical mechanisms in ethanol-induced cellular injury

1992 • 614 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

1994 • 550 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

Experimental liver cirrhosis induced by alcohol and iron.

1995 • 520 citations

Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat

1997 • 510 citations

Oxidative Stress, Toxicology, and Pharmacology of CYP2E1

2004 • 500 citations

Alcohol and mitochondria: A dysfunctional relationship

2002 • 484 citations

Oxidants and antioxidants in alcohol-induced liver disease

2003 • 483 citations

NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease

2000 • 476 citations

The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough

2002 • 463 citations

Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)

1994 • 441 citations

Current concepts in the pathogenesis of alcoholic liver injury

2001 • 384 citations

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

1998 • 361 citations

Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation

1990 • 361 citations

Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil

1998 • 310 citations

Pathogenesis of alcohol-induced accumulation of protein in the liver.

1977 • 308 citations

Hepatic mitochondrial glutathione: transport and role in disease and toxicity

2004 • 290 citations

Contribution of mitochondria to oxidative stress associated with alcoholic liver disease1 1This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury”. The full list of papers may be found on the homepage of the journal.

2002 • 289 citations

Markedly Enhanced Cytochrome P450 2E1 Induction and Lipid Peroxidation Is Associated with Severe Liver Injury in Fish Oil—Ethanol‐Fed Rats

1994 • 265 citations

Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts.

1986 • 263 citations

Alcohol-induced generation of lipid peroxidation products in humans

1999 • 249 citations

The role of kupffer cell oxidant production in early ethanol-induced liver disease,

2001 • 248 citations

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.

1991 • 247 citations

Impaired liver regeneration in inducible nitric oxide synthasedeficient mice

1998 • 246 citations

Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice

2003 • 236 citations

Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology

1997 • 235 citations

Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis

1992 • 235 citations

Nitric Oxide Prevents Tumor Necrosis Factor α–Induced Rat Hepatocyte Apoptosis by the Interruption of Mitochondrial Apoptotic Signaling Through S-Nitrosylation of Caspase-8

2000 • 233 citations

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

1992 • 228 citations

Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats

1983 • 224 citations

Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication

1997 • 221 citations

Ethanol toxicity and oxidative stress

1992 • 220 citations

Acute ethanol administration oxidatively damages and depletes mitochondrial dna in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants.

2001 • 220 citations

Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III

1999 • 218 citations

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride— and iron-dependent microsomal lipid peroxidation

1992 • 212 citations

CYP2E1-dependent toxicity and oxidative stress in HepG2 cells,

2001 • 210 citations

Feeding S -adenosyl-l-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

1995 • 205 citations

The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine

2003 • 203 citations

Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes

1998 • 203 citations

Role of malondialdehyde-acetaldehyde adducts in liver injury1,2 1Guest editor: Arthur Cederbaum 2This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury.” The full list of papers may be found on the homepage of the journal.

2002 • 202 citations

An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice

1999 • 201 citations

Cytochrome P450 2E1: its clinical and toxicological role

2000 • 200 citations

ETHANOL-INDUCED LIPID PEROXIDATION AND OXIDATIVE STRESS IN EXTRAHEPATIC TISSUES

1990 • 190 citations

Introduction—serial review: alcohol, oxidative stress and cell injury

2001 • 185 citations

Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury,

2001 • 178 citations

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease

1995 • 175 citations

Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver.

1967 • 171 citations

THE EFFECTS OF CHRONIC ETHANOL CONSUMPTION ON HEPATIC MITOCHONDRIAL ENERGY METABOLISM

1990 • 170 citations

Modification of the Mitochondrial Proteome in Response to the Stress of Ethanol-dependent Hepatotoxicity

2004 • 169 citations

Chronic Ethanol Consumption Alters the Glutathione/Glutathione Peroxidase‐1 System and Protein Oxidation Status in Rat Liver

2001 • 168 citations

Inhibition of Ethanol-Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole

2000 • 165 citations

Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease

2000 • 164 citations

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors

1995 • 164 citations

In vivo formation of a free radical metabolite of ethanol.

1990 • 164 citations

Gadolinium Chloride Blocks Alcohol-Dependent Liver Toxicity in Rats Treated Chronically with Intragastric Alcohol Despite the Induction of CYP2E1

1997 • 162 citations

Signaling Role of Intracellular Iron in NF-κB Activation

2003 • 161 citations

CYP2E1 is not involved in early alcohol-induced liver injury

1999 • 160 citations

Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption.

1991 • 155 citations

Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat

2001 • 154 citations

Role of mitochondria in alcoholic liver injury

2002 • 154 citations

Increased Production of Reactive Oxygen Species by Rat Liver Mitochondria After Chronic Ethanol Treatment

1994 • 153 citations

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

2002 • 153 citations

Effects of Alcohol Consumption on Indices of Iron Stores and of Iron Stores on Alcohol Intake Markers

2001 • 153 citations

Lipid peroxidation in ethanol poisoning: a critical reconsideration.

1985 • 153 citations

Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation.

1994 • 152 citations

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

2005 • 151 citations

Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis

1993 • 151 citations

CYP2E1: Biochemistry, Toxicology, Regulation and Function in Ethanol-Induced Liver Injury

2003 • 150 citations

Ethanol‐Inducible Cytochrome P450 (CYP2E1): Biochemistry, Molecular Biology and Clinical Relevance: 1996 Update

1996 • 150 citations

Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease*1

1995 • 146 citations

Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols

1991 • 146 citations

Effect of Ethanol on Cytochrome P450 2E1 (CYP2E1), Lipid Peroxidation, and Serum Protein Adduct Formation in Relation to Liver Pathology Pathogenesis

1993 • 144 citations

Impaired adaptive resynthesis and prolonged depletion of hepatic mitochondrial DNA after repeated alcohol binges in mice

2002 • 140 citations

Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients

1997 • 137 citations

Delivery of the Cu/Zn–Superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats

2001 • 136 citations

Spin trapping of free radical species produced during the microsomal metabolism of ethanol

1988 • 131 citations

Effects of Chronic Ethanol Administration on Rat Liver Proteasome Activities: Relationship With Oxidative Stress

1999 • 130 citations

The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes

2001 • 129 citations

Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress

1997 • 129 citations

Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion

2002 • 128 citations

Iron primes hepatic macrophages for NF-κB activation in alcoholic liver injury

1999 • 126 citations

Ebselen prevents early alcohol-induced liver injury in rats

2001 • 124 citations

The glutathione precursorL-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat

2000 • 123 citations

Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells.

1995 • 122 citations

Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol

1997 • 122 citations

Depressed selenium and vitamin E levels in an alcoholic population

1986 • 119 citations

Chronic Ethanol Consumption Affects Glutathione Status in Rat Liver , ,

1998 • 117 citations

Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis

1995 • 116 citations

Nitric Oxide in Liver Diseases

2002 • 116 citations

Iron activates NF-κB in Kupffer cells

2002 • 116 citations

INCREASED FREE-RADICAL ACTIVITY IN ALCOHOLICS

1985 • 112 citations

Nitric oxide production in experimental alcoholic liver disease in the rat: Role in protection from injury

1995 • 112 citations

Free radical mechanisms in immune reactions associated with alcoholic liver disease

2002 • 112 citations

The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice

2004 • 111 citations

Evidence of Proteasome-mediated Cytochrome P-450 Degradation

1997 • 109 citations

Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase

2003 • 107 citations

The Effect of Ethanol-Induced Cytochrome p4502E1 on the Inhibition of Proteasome Activity by Alcohol

2000 • 107 citations

Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers.

1993 • 100 citations

Modulation of Caspase‐3 Activity and Fas Ligand mRNA Expression in Rat Liver Cells In Vivo by Alcohol and Lipopolysaccharide

1999 • 99 citations

Expression of Base Excision DNA Repair Genes Is a Sensitive Biomarker for in Vivo Detection of Chemical-induced Chronic Oxidative Stress

2004 • 98 citations

Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration.

1989 • 98 citations

Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: Relationship to liver disease severity and alcohol consumption

1997 • 96 citations

Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture

1997 • 93 citations

Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration.

2001 • 93 citations

Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation

1995 • 93 citations

Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats

1998 • 92 citations

ReviewA Review of the Role of Reactive Oxygen and Nitrogen Species in Alcohol-induced Mitochondrial Dysfunction

2003 • 90 citations

Alcohol Mediates Increases in Hepatic and Serum Nonheme Iron Stores in a Rat Model for Alcohol‐Induced Liver Injury

1996 • 88 citations

Delivery of I[kappa ]B superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats

2001 • 85 citations

Myocardial Oxidative Stress and Toxicity Induced by Acute Ethanol Exposure in Mice

2004 • 83 citations

Alcohol-induced free radicals in mice: Direct toxicants or signaling molecules?

2001 • 80 citations

Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats

1999 • 80 citations

Chronic Alcohol Administration Stimulates Nitric Oxide Formation in the Rat Liver With or Without Pretreatment by Lipopolysaccharide

1995 • 79 citations

Potentiation by Chronic Ethanol Treatment of the Mitochondrial Permeability Transition

1999 • 77 citations

Ethanol-derived immunoreactive species formed by free radical mechanisms.

1994 • 76 citations

Chronic ethanol administration causes oxidative stress in the rat pancreas

1998 • 76 citations

Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease.

1996 • 75 citations

Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration

1998 • 73 citations

ORAL TREATMENT OF PERNICIOUS ANÆMIA WITH LOW DOSES OF H.P.P./1

1960 • 71 citations

The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats

2002 • 69 citations

LIPID PEROXIDATION IN ETHANOL POISONING: A CRITICAL RECONSIDERATION

1985 • 66 citations

Lipid peroxidation: A mechanism for alcohol-induced testicular injury

1989 • 65 citations

Role of Superoxide and Trace Transition Metals in the Production of α-Hydroxyethyl Radical from Ethanol by Microsomes from Alcohol Dehydrogenase-Deficient Deermice

1993 • 64 citations

Iron and CYP2E1-dependent oxidative stress and toxicity

2003 • 63 citations

Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration.

2001 • 62 citations

Effect of Chronic Ethanol Administration on Protein Catabolism in Rat Liver

1989 • 62 citations

Evidence That the Rat Hepatic Mitochondrial Carrier Is Distinct from the Sinusoidal and Canalicular Transporters for Reduced Glutathione

1995 • 59 citations

Adduction of Soluble Proteins with Malondialdehyde‐Acetaldehyde (MAA) Induces Antibody Production and Enhances T‐Cell Proliferation

2002 • 59 citations

The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats.

1994 • 58 citations

Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide

2003 • 58 citations

Autoimmune Responses Against Oxidant Stress and Acetaldehyde‐Derived Epitopes in Human Alcohol Consumers

2000 • 54 citations

Hepatic Iron Uptake in Alcoholic Liver Disease

1983 • 53 citations

NADPH-Dependent Microsomal Electron Transfer Increases Degradation of CYP2E1 by the Proteasome Complex: Role of Reactive Oxygen Species

1999 • 52 citations

Hepatotoxicity induced by iron overload and alcohol

1996 • 52 citations

Immunohistochemical Detection of 4-Hydroxy-2-nonenal-Modified-Protein Adducts in Human Alcoholic Liver Diseases

1998 • 50 citations

Generation of reactive oxygen intermediates by human liver microsomes in the presence of NADPH or NADH.

1994 • 49 citations

Possible Roles of Free Radicals in Alcoholic Tissue Damage

1990 • 48 citations

Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite.

1999 • 45 citations

Spin trapping evidence for alcohol-associated oxidative stress1,2 1This article is part of a series of reviews on “Alcohol, Oxidative Stress, and Cell Injury.” The full list of papers may be found on the homepage of the journal.

2002 • 43 citations

Oxidative stress from alcohol in the brain.

1987 • 41 citations

The ubiquitin‐proteasome system and its role in ethanol‐induced disorders

2002 • 39 citations

Effect of acute ethanol administration on the subcellular distribution of iron in rat liver and cerebellum

1990 • 36 citations

Immunohistochemical Detection of 4-Hydroxy-2-nonenal-Modified-Protein Adducts in Human Alcoholic Liver Diseases

1998 • 35 citations

Metabolism of ethanol to 1-hydroxyethyl radicals in vivo: detection with intravenous administration of alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone.

1995 • 34 citations

Inhibition of Ethanol-Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole

2000 • 34 citations

Plasma phosphatidylcholine hydroperoxide as a new marker of oxidative stress in alcoholic patients

2004 • 33 citations

Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity

2004 • 31 citations

Mitochondrial Glutathione and Chemically Induced Stress Including Ethanol

2004 • 31 citations

Evidence for Increased Oxidative Stress in Alcohol‐Dependent Patients Provided by Quantification of in Vivo Salicylate Hydroxylation Products

1997 • 29 citations

Increase in cellular pool of low-molecular-weight iron during ethanol metabolism in rat hepatocyte cultures

1995 • 28 citations

Effect of Chronic Alcohol Feeding on Hepatic Iron Status and Ferritin Uptake by Rat Hepatocytes

1993 • 26 citations

Interaction of 1-Hydroxyethyl Radical with Antioxidant Enzymes

1999 • 23 citations

Chronic ethanol feeding causes oxidative stress in rat liver mitochondria. Prevention by S-adenosyl methionine

1999 • 23 citations

The effect of Viagra (sildenafil citrate) on liver injury caused by chronic ethanol intragastric feeding in rats

2004 • 21 citations

COMPARISON OF THE FORMATION OF PROTEINS MODIFIED BY DIRECT AND INDIRECT ETHANOL METABOLITES IN THE LIVER AND BLOOD OF RATS FED THE LIEBER-DE CARLI LIQUID DIET

2000 • 21 citations

Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication

1997 • 21 citations

In Vitro Exposure to Malondialdehyde‐Acetaldehyde Adducted Protein Inhibits Cell Proliferation and Viability

2002 • 12 citations

Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture

1997 • 11 citations

Roles of Kupffer Cells in Alcoholic Liver Disease

2005 • 11 citations

Deleted Work

1955 • 0 citations