Delivery of the Cu/Zn–Superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

[13] Catalase in vitro

1984 • 22,648 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Glutathione: Metabolism and function

1978 • 971 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

1991 • 743 citations

Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

1999 • 704 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

1994 • 627 citations

Inactivation of Kupffer cells prevents early alcohol-induced liver injury

1994 • 550 citations

A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

1989 • 517 citations

Alcohol and the liver: 1994 update

1994 • 511 citations

Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat

1997 • 510 citations

NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease

2000 • 476 citations

Biochemical and Molecular Basis of Alcohol-Induced Injury to Liver and Other Tissues

1988 • 452 citations

Alcohol and the Liver

1992 • 421 citations

Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.

1987 • 400 citations

The Utility of Superoxide Dismutase in Studying Free Radical Reactions

1970 • 389 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice

1993 • 345 citations

Preparation of Pure Hepatocytes and Reticuloendothelial Cells in High Yield From a Single Rat Liver by Means of Percoll Centrifugation and Selective Adherence

1985 • 324 citations

Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil

1998 • 310 citations

Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol

1996 • 278 citations

Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation

1998 • 263 citations

Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro.

1987 • 242 citations

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

1992 • 228 citations

Recombinant superoxide dismutase reduces oxygen free radical concentrations in reperfused myocardium.

1987 • 190 citations

Tumor Necrosis Factor Stimulates Hepatic Lipid Synthesis and Secretion*

1989 • 183 citations

Long-term cannulation model for blood sampling and intragastric infusion in the rat

1984 • 175 citations

Immune Responses to Reporter Proteins and High Viral Dose Limit Duration of Expression with Adenoviral Vectors: Comparison of E2a Wild Type and E2a Deleted Vectors

1997 • 173 citations

In vivo formation of a free radical metabolite of ethanol.

1990 • 164 citations

Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats

1978 • 163 citations

CYP2E1 is not involved in early alcohol-induced liver injury

1999 • 160 citations

Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis

1993 • 151 citations

Mitochondrial glutathione depletion in alcoholic liver disease

1993 • 151 citations

Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats.

1993 • 143 citations

Spin trapping of free radical species produced during the microsomal metabolism of ethanol

1988 • 131 citations

Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells.

1995 • 122 citations

The formation of a novel free radical metabolite from CCl4 in the perfused rat liver and in vivo.

1986 • 108 citations

O2-. release by activated Kupffer cells upon hypoxia-reoxygenation

1991 • 103 citations

Enhanced activity of the free radical producing enzyme xanthine oxidase in hypoxic rat liver. Regulation and pathophysiologic significance.

1991 • 101 citations

Overexpression of Human Superoxide Dismutase Inhibits Oxidation of Low-Density Lipoprotein by Endothelial Cells

1998 • 94 citations

Lipid peroxidation as a mechanism of alcoholic liver injury: Role of iron mobilization and microsomal induction

1988 • 90 citations

WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes

1998 • 83 citations

Allopurinol prevents early alcohol-induced liver injury in rats.

2000 • 81 citations

Increased oxygen radical‐dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption

1988 • 70 citations

Nutrition in the pathogenesis of alcoholic liver disease.

1993 • 68 citations

CYP-2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet.

1995 • 67 citations

Hydroxyl Radical Generation by Microsomes after Chronic Ethanol Consumption

1987 • 55 citations

Cloning Vectors Derived from Animal Viruses

1983 • 54 citations

Effects of the superoxide radical scavenger superoxide dismutase, and of the hydroxyl radical scavenger mannitol, on reperfusion injury in isolated rabbit hearts

1992 • 52 citations

LEUCOCYTE ADHESION MOLECULES AND ALCOHOLIC LIVER DISEASE

1994 • 34 citations

NUTRITION IN THE PATHOGENESIS OF ALCOHOLIC LIVER DISEASE

1993 • 30 citations