Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Prevalence and Trends in Obesity Among US Adults, 1999-2000

2002 • 6,312 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

1999 • 4,825 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000

2002 • 4,212 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia

2001 • 3,408 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients

2000 • 3,142 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

2001 • 2,534 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

2002 • 2,081 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

2001 • 1,903 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Adipose Tissue as an Endocrine Organ

2000 • 1,568 citations

Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

2002 • 1,540 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

1994 • 1,302 citations

The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition

2002 • 1,291 citations

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

1997 • 1,246 citations

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

2002 • 1,210 citations

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

2001 • 1,202 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

2001 • 1,144 citations

Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation

2002 • 1,132 citations

Adiponectin and protection against type 2 diabetes mellitus

2003 • 1,130 citations

Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys

2001 • 1,091 citations

Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

2003 • 1,063 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

Adipose tissue as an endocrine and paracrine organ

1998 • 1,000 citations

Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

2003 • 922 citations

Stromal Effects on Mammary Gland Development and Breast Cancer

2002 • 902 citations

Resistin is expressed in human macrophages and directly regulated by PPARγ activators

2003 • 898 citations

Adipose tissue mass can be regulated through the vasculature

2002 • 821 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

2002 • 806 citations

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

1994 • 792 citations

Life without white fat: a transgenic mouse

1998 • 782 citations

Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans

2001 • 748 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 694 citations

Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome 3q27-qter and Independent Replication of a Type 2–Diabetes Locus on Chromosome 1q21–q24

2000 • 686 citations

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

2000 • 669 citations

Hormonal Regulation of Adiponectin Gene Expression in 3T3-L1 Adipocytes

2002 • 665 citations

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome

2000 • 638 citations

Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

1998 • 625 citations

An Iron Delivery Pathway Mediated by a Lipocalin

2002 • 619 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 614 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 588 citations

Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization

2002 • 575 citations

Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

2002 • 557 citations

Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation

2001 • 554 citations

Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States).

2002 • 552 citations

Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin

2003 • 539 citations

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

2002 • 529 citations

Leptin-specific patterns of gene expression in white adipose tissue

2000 • 519 citations

The Function of Leptin in Nutrition, Weight, and Physiology

2002 • 512 citations

Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in Morbidly Obese Subjects

2003 • 509 citations

Preadipocyte Conversion to Macrophage

2003 • 508 citations

Trends and Correlates of Class 3 Obesity in the United States From 1990 Through 2000

2002 • 469 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

2003 • 427 citations

Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists

2001 • 419 citations

Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

1987 • 398 citations

Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control

2003 • 385 citations

The expression of adipogenic genes is decreased in obesity and diabetes mellitus

2000 • 383 citations

Decreased food intake does not completely account for adiposity reduction after ob protein infusion.

1996 • 380 citations

Genomic structure and mutations in adipose-specific gene, adiponectin

2000 • 379 citations

How Drosophila combats microbial infection: a model to study innate immunity and host–pathogen interactions

2002 • 365 citations

The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes

2000 • 348 citations

Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

2003 • 346 citations

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

2003 • 344 citations

Increased Resistin Gene and Protein Expression in Human Abdominal Adipose Tissue

2002 • 343 citations

Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin Resistance

2002 • 327 citations

Severely Impaired Adipsin Expression in Genetic and Acquired Obesity

1987 • 319 citations

Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity

1989 • 303 citations

Adipose Tissue Is a Major Source of Interleukin-1 Receptor Antagonist

2003 • 284 citations

Inflammatory pathways in atherosclerosis and acute coronary syndromes

2001 • 283 citations

Resistin release by human adipose tissue explants in primary culture

2003 • 258 citations

Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue

2001 • 257 citations

A Proteomic Approach for Identification of Secreted Proteins during the Differentiation of 3T3-L1 Preadipocytes to Adipocytes

2002 • 251 citations

Role of Serum Amyloid A During Metabolism of Acute-Phase HDL by Macrophages

2000 • 238 citations

Minireview: Human Obesity—Lessons from Monogenic Disorders

2003 • 224 citations

Leptin: a multifunctional hormone

2000 • 211 citations

Leptin Transport Across the Blood-Brain Barrier: Implications for the Cause and Treatment of Obesity

2001 • 144 citations

Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility

2003 • 140 citations

Analysis of gene expression profile during 3T3-L1 preadipocyte differentiation

2000 • 138 citations

Cloning of cell-specific secreted and surface proteins by subtractive antibody screening

1998 • 135 citations

Characterization of the long pentraxin PTX3 as a TNFα-induced secreted protein of adipose cells

2003 • 135 citations

Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle

2003 • 135 citations

1-Butyryl-Glycerol: A novel angiogenesis factor secreted by differentiating adipocytes

1990 • 124 citations

The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inflammatory status in obese subjects

2002 • 118 citations

Capacity of adipose tissue to promote growth and metastasis of a murine mammary carcinoma: Effect of estrogen and progesterone

1992 • 104 citations

White Adipocyte Vascular Endothelial Growth Factor: Regulation by Insulin

2002 • 100 citations

Acylation-stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/obMice

2002 • 98 citations

Identification of Macrophage Migration Inhibitory Factor in Adipose Tissue and Its Induction by Tumor Necrosis Factor-α

1997 • 89 citations

The genetics of adiponectin

2003 • 85 citations

Of mice and men (and women) and the acylation-stimulating protein pathway

2000 • 64 citations

Functional Characterization of the Human Resistin Promoter with Adipocyte Determination- and Differentiation-Dependent Factor 1/Sterol Regulatory Element Binding Protein 1c and CCAAT Enhancer Binding Protein-α

2003 • 59 citations

Resistin: a new link between obesity and insulin resistance?

2001 • 55 citations

Leptin and the pituitary.

2001 • 46 citations

Identification and characterization of leptin-containing intracellular compartment in rat adipose cells

2000 • 46 citations

[The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure].

2002 • 44 citations

Lipoprotein Lipase and Leptin Are Accumulated in Different Secretory Compartments in Rat Adipocytes

2001 • 35 citations

NFκB Interacts with Serum Amyloid A3 Enhancer Factor to Synergistically Activate Mouse Serum Amyloid A3 Gene Transcription

2000 • 34 citations

Leptin: a novel therapeutic role in lipodystrophy

2002 • 32 citations

Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity.

1991 • 30 citations

Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol.

1993 • 20 citations