Distinct Roles of the Steroid Receptor Coactivator 1 and of MED1 in Retinoid-induced Transcription and Cellular Differentiation

Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter

2003 • 1,422 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

1995 • 1,085 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

Induction of an interferon response by RNAi vectors in mammalian cells

2003 • 972 citations

Elongation by RNA polymerase II: the short and long of it

2004 • 701 citations

Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

1998 • 685 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

1999 • 630 citations

Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14

2000 • 562 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

1998 • 454 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Dynamic regulation of pol II transcription by the mammalian Mediator complex

2005 • 382 citations

TFIIH is negatively regulated by cdk8-containing mediator complexes

2000 • 381 citations

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

1998 • 337 citations

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

1998 • 330 citations

A Set of Consensus Mammalian Mediator Subunits Identified by Multidimensional Protein Identification Technology

2004 • 314 citations

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

1998 • 305 citations

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

2002 • 300 citations

Involvement of the TRAP220 Component of the TRAP/SMCC Coactivator Complex in Embryonic Development and Thyroid Hormone Action

2000 • 287 citations

Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

2001 • 273 citations

Mice deficient in the steroid receptor co-activator 1(SRC-1) are resistant to thyroid hormone

1999 • 255 citations

Progesterone and Glucocorticoid Receptors Recruit Distinct Coactivator Complexes and Promote Distinct Patterns of Local Chromatin Modification

2003 • 244 citations

From embryonal carcinoma cells to neurons: The P19 pathway

1994 • 239 citations

PARP-1 Determines Specificity in a Retinoid Signaling Pathway via Direct Modulation of Mediator

2005 • 227 citations

A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription

2003 • 204 citations

Physical and Functional Interactions between Cellular Retinoic Acid Binding Protein II and the Retinoic Acid-Dependent Nuclear Complex

1999 • 200 citations

Antiapoptotic role of the p38 mitogen-activated protein kinase–myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

2000 • 193 citations

ATP-Driven Chromatin Remodeling Activity and Histone Acetyltransferases Act Sequentially during Transactivation by RAR/RXR In Vitro

2000 • 184 citations

Transcriptional Activities of Retinoic Acid Receptors

2005 • 122 citations

Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity

2001 • 120 citations

Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1-Responsive Promoter

2002 • 115 citations

The Targeted Disruption of Both Alleles of RARβ2 in F9 Cells Results in the Loss of Retinoic Acid-associated Growth Arrest

1999 • 113 citations

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

2002 • 110 citations

Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters

1994 • 110 citations

Application of a Fluorescent Histone Acetyltransferase Assay to Probe the Substrate Specificity of the Human p300/CBP-Associated Factor

2000 • 89 citations

Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins.

1995 • 83 citations

Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction

2004 • 82 citations

Commitment to differentiation induced by retinoic acid in P19 embryonal carcinoma cells is cell cycle dependent

1987 • 76 citations

RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells

1996 • 68 citations

The Thyroid Hormone Receptor-Associated Protein TRAP220 Is Required at Distinct Embryonic Stages in Placental, Cardiac, and Hepatic Development

2003 • 59 citations

Phosphorylation of histone H3 is functionally linked to retinoic acid receptor β promoter activation

2002 • 49 citations

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression

1999 • 45 citations

Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RARα

1992 • 43 citations

Retinobenzoic acids. 3. Structure-activity relationships of retinoidal azobenzene-4-carboxylic acids and stilbene-4-carboxylic acids

1989 • 43 citations

Allosteric Regulation of the Discriminative Responsiveness of Retinoic Acid Receptor to Natural and Synthetic Ligands by Retinoid X Receptor and DNA

1999 • 39 citations

Identification of Mouse TRAP100: a Transcriptional Coregulatory Factor for Thyroid Hormone and Vitamin D Receptors

1999 • 36 citations

Control of Retinoic Acid Receptor Heterodimerization by Ligand-induced Structural Transitions

2001 • 34 citations

Expression of the Ligand-Binding Domain-Containing Region of Retinoic Acid Receptors .ALPHA., .BETA. and .GAMMA. in Escherichia coli and Evaluation of Ligand-Binding Selectivity.

1993 • 26 citations

Chromosomal Integration of Retinoic Acid Response Elements Prevents Cooperative Transcriptional Activation by Retinoic Acid Receptor and Retinoid X Receptor

2002 • 26 citations

The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein-protein interaction

2005 • 25 citations

Retinoid Isomers Differ in the Ability to Induce Release of SMRT Corepressor from Retinoic Acid Receptor-α

1999 • 22 citations

H11-H12 Loop Retinoic Acid Receptor Mutants Exhibit Distinct trans-Activating and trans-Repressing Activities in the Presence of Natural or Synthetic Retinoids

1998 • 21 citations

Neurons derived from embryonal carcinoma (P19) cells express multiple GABAA receptor subunits and fully functional GABAA receptors

1994 • 21 citations

Selective alteration of gene expression in response to natural and synthetic retinoids.

2002 • 15 citations

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression [published erratum appears in Proc Natl Acad Sci U S A 1999 Mar 16;96(6):3330]

1999 • 14 citations

Correction

1998 • 1 citations