A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

The Protein Data Bank

2000 • 35,287 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

2002 • 1,160 citations

DOCK 4.0: search strategies for automated molecular docking of flexible molecule databases.

2001 • 1,132 citations

Further development and validation of empirical scoring functions for structure-based binding affinity prediction.

2002 • 1,097 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation

1998 • 666 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

2001 • 617 citations

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

2003 • 562 citations

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

2002 • 526 citations

Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway

2003 • 502 citations

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

2003 • 441 citations

Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation

2001 • 436 citations

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene

1999 • 383 citations

Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.

1997 • 370 citations

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

2002 • 369 citations

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

2002 • 310 citations

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

2001 • 263 citations

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C

2004 • 257 citations

IL-6 up-regulates Mcl-1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway

1999 • 249 citations

Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

2003 • 238 citations

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells.

2000 • 212 citations

Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells

1999 • 196 citations

Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.

1997 • 189 citations

STAT proteins as novel targets for cancer therapy

1999 • 180 citations

Stat3 modulates heat shock 27 kDa protein expression in breast epithelial cells

2004 • 56 citations

Modulation of Janus kinase 2 by cisplatin in cancer cells

2004 • 26 citations