Irinotecan (CPT-11): pharmacology and clinical applications

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung Cancer

1991 • 1,401 citations

DNA Topoisomerases

1981 • 977 citations

Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium

1988 • 961 citations

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

Dose: A critical factor in cancer chemotherapy

1980 • 851 citations

EFFECT OF GRANULOCYTE COLONY STIMULATING FACTOR ON NEUTROPENIA INDUCED BY CYTOTOXIC CHEMOTHERAPY

1988 • 740 citations

Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer

1987 • 605 citations

Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer.

1986 • 454 citations

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer.

1992 • 443 citations

Topoisomerase-targeting antitumor drugs

1989 • 441 citations

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

1992 • 438 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Effect of Granulocyte Colony-Stimulating Factor after Intensive Induction Therapy in Relapsed or Refractory Acute Leukemia

1990 • 403 citations

Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.

1993 • 392 citations

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

1981 • 350 citations

Irinotecan is an active agent in untreated patients with metastatic colorectal cancer.

1996 • 340 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Phase I and pharmacokinetic trial of weekly CPT-11.

1993 • 300 citations

Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients.

1995 • 296 citations

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

1990 • 292 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

Pregnancy-specific beta-glycoprotein in complications of early pregnancy.

1980 • 280 citations

Phase I Study of Weekly Intravenous Infusions of CPT-11, a New Derivative of Camptothecin, in the Treatment of Advanced Non-Small-Cell Lung Cancer

1991 • 275 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

Irinotecan (CPT-11) High-Dose Escalation Using Intensive High-Dose Loperamide to Control Diarrhea

1994 • 242 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

1980 • 232 citations

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

1991 • 231 citations

Effects of CPT‐11 in combination with other anti‐cancer agents in culture

1992 • 226 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin

1971 • 213 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks.

1994 • 195 citations

Action of camptothecin on mammalian cells in culture.

1972 • 190 citations

The chemotherapy of lymphomas: looking back, moving forward--the Richard and Hinda Rosenthal Foundation award lecture.

1987 • 180 citations

Mechanism of action of cis-dichlorodiammineplatinum(II).

1979 • 173 citations

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

1989 • 172 citations

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

1991 • 168 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.

1991 • 159 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients.

1994 • 151 citations

CPT-11 in combination with cisplatin for advanced non-small-cell lung cancer.

1992 • 144 citations

Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

1991 • 144 citations

CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties.

1991 • 139 citations

Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.

1990 • 133 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content.

1990 • 124 citations

Phase I Study and Pharmacokinetics of CPT-11 With 5-Day Continuous Infusion

1992 • 122 citations

Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice

1992 • 112 citations

Nonlinear pharmacokinetics of CPT-11 in rats.

1990 • 109 citations

Sequential administration of camptothecin and etoposide circumvents the antagonistic cytotoxicity of simultaneous drug administration in slowly growing human colon carcinoma HT-29 cells

1992 • 109 citations

Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors

1995 • 107 citations

Unknotting the Complexities of Multidrug Resistance: The Involvement of DNA Topoisomerases in Drug Action and Resistance

1989 • 107 citations

Review of the current clinical status of platinum coordination complexes in cancer chemotherapy.

1975 • 104 citations

Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion

1991 • 101 citations

New Natural Products in Cancer Chemotherapy

1990 • 101 citations

Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancer

1993 • 94 citations

Phase I study of irinotecan and cisplatin with granulocyte colony-stimulating factor support for advanced non-small-cell lung cancer.

1994 • 93 citations

Inhibition of spontaneous and experimental metastasis by a new derivative of camptothecin, CPT-11, in mice

1988 • 87 citations

[A late phase II study of CPT-11 on uterine cervical cancer and ovarian cancer. Research Groups of CPT-11 in Gynecologic Cancers].

1991 • 82 citations

The application of dose intensity to problems in chemotherapy of ovarian and endometrial cancer.

1987 • 77 citations

Enhanced Antitumor Efficacy of a Combination of CPT‐11, a New Derivative of Camptothecin, and Cisplatin against Human Lung Tumor Xenografts

1993 • 70 citations

Plasma camptothecin (NSC-100880) levels during a 5-day course of treatment: relation to dose and toxicity.

1972 • 68 citations

[Phase I clinical study of CPT-11. Research group of CPT-11].

1990 • 65 citations

Phase I and pharmacologic study of irinotecan and etoposide with recombinant human granulocyte colony-stimulating factor support for advanced lung cancer.

1994 • 62 citations

Lethal activity of camptothecin sodium on human lymphoma cells.

1974 • 54 citations

Activity of CPT-11 (irinotecan hydrochloride), a topoisomerase I inhibitor, against human tumor colony-forming units

1994 • 52 citations

Phase I study of CPT-11 and etoposide in patients with refractory solid tumors.

1993 • 48 citations

[An early phase II study of CPT-11 in primary lung cancer].

1991 • 38 citations

[Effect of administration schedules on the antitumor activity of CPT-11, a camptothecin derivative].

1990 • 25 citations

The Treatment of Hodgkin's Disease.

1970 • 23 citations

[An early phase II study of CPT-11 in gynecologic cancers. Research Group of CPT-11 in Gynecologic Cancers].

1991 • 21 citations

CODE Chemotherapy with or without Recombinant Human Granulocyte Colony-Stimulating Factor in Extensive-Stage Small Cell Lung Cancer

1992 • 21 citations

[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].

1988 • 19 citations

Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors.

1987 • 18 citations

Inhibition of DNA synthesis and DNA fragmentation in stimulated splenocytes by the concerted action of topoisomerase I and II poisons

1993 • 18 citations

[Conversion of CPT-11 into SN-38 in human tissues].

1991 • 18 citations

Action of 7-ethylcamptothecin on tumor cells and its disposition in mice.

1987 • 18 citations

Action of (S)-10-hydroxycamptothecin on P388 leukemia and distribution of the drug in mice.

1983 • 7 citations

[Preclinical evaluation of a new camptothecin derivative, CPT-11, on the subrenal capsule assay].

1987 • 7 citations

[Distribution and excretion of 10-hydroxycamptothecin and its influence on immune response (author's transl)].

1980 • 5 citations

TREATMENT OF HODGKIN'S DISEASE

1973 • 2 citations

33 Pharmacokinetic variability of active lactones of CPT-11 and SN-38

1993 • 1 citations

Deleted Work

1955 • 0 citations