Inhibition of DNA synthesis and DNA fragmentation in stimulated splenocytes by the concerted action of topoisomerase I and II poisons

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

DNA Topoisomerases

1981 • 977 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Culture of Normal Human Leukocytes

1967 • 774 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 491 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1989 • 445 citations

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.

1990 • 427 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase α

1981 • 389 citations

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.

1989 • 368 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro.

1987 • 293 citations

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

1978 • 234 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells

1976 • 187 citations

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

1989 • 174 citations

Proliferation dependence of topoisomerase II-mediated drug action

1986 • 170 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product.

1987 • 167 citations

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

1991 • 165 citations

DNA topoisomerase II from Drosophila melanogaster. Purification and physical characterization.

1983 • 145 citations

Topoisomerase-specific drug sensitivity in relation to cell cycle progression.

1987 • 144 citations

Effects of the epipodophyllotoxin VP-16-213 on cell cycle traverse, DNA synthesis, and DNA strand size in cultures of human leukemic lymphoblasts.

1983 • 114 citations

Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin

1971 • 109 citations

Cell cycle stage-dependent variations in drug-induced topoisomerase II mediated DNA cleavage and cytotoxicity

1987 • 103 citations

DNA topoisomerase activities in concanavalin A‐stimulated lymphocytes

1984 • 102 citations

Cell death induced by topoisomerase inhibitors

1991 • 89 citations

DNA topoisomerase II as a target of antineoplastic drug therapy

1985 • 83 citations

Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes

1988 • 50 citations

Novobiocin induces the in vivo cleavage of active gene sequences in intact cells.

1986 • 24 citations

Measurement of the DNA Synthetic Capacity of Activated Lymphocytes: Nucleotide Triphosphate Incorporation by Permeabilized Cells

1978 • 10 citations

Measurement of the DNA synthetic capacity of activated lymphocytes: nucleotide triphosphate incorporation by permeabilized cells.

1978 • 10 citations

Effects of BD-40, an ellipticine analogue (aza-ellipticine) on cell cycle traverse and DNA synthesis in cultures of synchronized mouse fibroblasts

1984 • 7 citations

Influence on certain amino acids on steps leading to DNA synthesis in concanavalin A-treated guinea-pig lymphocytes.

1977 • 5 citations