CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*

1964 • 18,916 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

Isoelectric Fractionation, Analysis, and Characterization of Ampholytes in Natural pH Gradients. IV. Further Studies on the Resolving Power in Connection with Separation of Myoglobins.

1966 • 1,303 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

1990 • 292 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

1980 • 232 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin

1971 • 213 citations

Action of camptothecin on mammalian cells in culture.

1972 • 190 citations

alpha-Chymotrypsin: Enzyme concentration and kinetics

1967 • 175 citations

Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans

1990 • 162 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Lethal activity of camptothecin sodium on human lymphoma cells.

1974 • 54 citations

Purification and Enzymatic Properties of Rat Serum Carboxylesterase

1978 • 24 citations

[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].

1988 • 19 citations

Action of 7-ethylcamptothecin on tumor cells and its disposition in mice.

1987 • 18 citations