Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Turns in Peptides and Proteins

1985 • 1,658 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Immunoblotting and dot immunobinding — Current status and outlook

1984 • 979 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

1981 • 350 citations

High Titers of Autoantibodies to Topoisomerase I (Scl-70) in Sera from Scleroderma Patients

1986 • 307 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

1988 • 260 citations

Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene.

1985 • 193 citations

Identification of a vaccinia virus gene encoding a type I DNA topoisomerase.

1987 • 148 citations

Characterization of vaccinia virus DNA topoisomerase I expressed in Escherichia coli.

1988 • 143 citations

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

1989 • 137 citations

Camptothecin-resistant mutants of Chinese hamster ovary cells containing a resistant form of topoisomerase I.

1988 • 125 citations

Radial Locations of Amino Acid Residues in a Globular Protein: Correlation with the Sequence1

1986 • 97 citations

Effects of camptothecin on RNA synthesis in leukemia L1210 cells

1971 • 94 citations

Camptothecin effects on DNA synthesis in murine leukemia cells

1972 • 87 citations

Selective Interruption of High Molecular Weight RNA Synthesis in HeLa Cells by Camptothecin

1972 • 87 citations

Cloning and sequencing ofSchizosaccharomyces pombeDNA topoisomerase I gene, and effect of gene disruption

1987 • 85 citations

Characterization of a camptothecin-resistant human DNA topoisomerase I.

1988 • 82 citations

Efficient secretion and purification of human insulin-like growth factor I with a gene fusion vector inStaphylococci

1985 • 80 citations

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli.

1987 • 66 citations

Rapid purification and characterization of DNA topoisomerase I from cultured mouse mammary carcinoma FM3A cells.

1983 • 64 citations

Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1

1989 • 54 citations

Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli.

1989 • 31 citations