Back to search

Irinotecan is an active agent in untreated patients with metastatic colorectal cancer.

Data up to Jan 2025

Published1996
Citations340
References30

Total Citations Per Year

Abstract

References (30)

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

1966 • 2,159 citations

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.

1992 • 1,198 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

The Current Status of Camptothecin Analogues as Antitumor Agents

1993 • 614 citations

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer.

1992 • 443 citations

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

1992 • 438 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

1981 • 350 citations

Phase I and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients.

1995 • 296 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Irinotecan (CPT-11) High-Dose Escalation Using Intensive High-Dose Loperamide to Control Diarrhea

1994 • 242 citations

Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.

1990 • 226 citations

Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors

1994 • 208 citations

Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks.

1994 • 195 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

1991 • 168 citations

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice

1991 • 163 citations

Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.

1995 • 157 citations

Prognostic factors in advanced colorectal carcinoma

1983 • 144 citations

Inhibition of spontaneous and experimental metastasis by a new derivative of camptothecin, CPT-11, in mice

1988 • 87 citations

Characterization of a camptothecin-resistant human DNA topoisomerase I.

1988 • 82 citations

Topoisomerase I and II activity in human breast, cervix, lung and colon cancer

1994 • 81 citations

Topoisomerase I alteration in a camptothecin-resistant cell line derived from Chinese hamster DC3F cells in culture.

1992 • 71 citations

Pharmacological Correlation between Total Drug Concentration and Lactones of CPT‐11 and SN‐38 in Patients Treated with CPT‐11

1995 • 54 citations

Systemic Therapy in Metastatic Colorectal Cancer

1990 • 22 citations

[Effect of chemotherapy using irinotecan (CPT-11) against recurrent colorectal cancer].

1995 • 10 citations

Cited By (0)

No citing papers found in database

Irinotecan is an active agent in untreated patients with metastatic colorectal cancer. (1996) – Journal of Clinical Oncology | Metascience Observatory Explorer