Release of Glutamate, Aspartate, and γ‐Aminobutyric Acid from Isolated Nerve Terminals

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

1984 • 824 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

THE STRUCTURAL SPECIFICITY OF THE HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMATE AND <scp>l</scp>‐ASPARTATE BY RAT BRAIN SLICES

1972 • 694 citations

Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

1975 • 559 citations

Protein Phosphorylation and Neuronal Function

1985 • 525 citations

GABA in Nervous System Function

1977 • 503 citations

High affinity uptake systems for glycine, glutamic and aspartic acids in synaptosomes of rat central nervous tissues

1972 • 476 citations

Mechanism of Transport and Storage of Neurotransmitter

1987 • 471 citations

Calcium‐Dependent and‐Independent Release of Glutamate from Synaptosomes Monitored by Continuous Fluorometry

1987 • 459 citations

A simple apparatus for studying the release of neurotransmitters from synaptosomes

1974 • 456 citations

Characterization of Glutamate Uptake into Synaptic Vesicles

1985 • 437 citations

Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ

1980 • 391 citations

Membrane potentials in pinched‐off presynaptic nerve ternimals monitored with a fluorescent probe: evidence that synaptosomes have potassium diffusion potentials.

1975 • 389 citations

Synaptosomes possess an exocytotic pool of glutamate

1986 • 368 citations

Calcium channel currents and their inhibition by (‐)‐baclofen in rat sensory neurones: modulation by guanine nucleotides.

1987 • 342 citations

Mitochondrial calcium transport

1980 • 304 citations

Phorbol Ester Enhancement of Neurotransmitter Release from Rat Brain Synaptosomes

1987 • 273 citations

Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart

1978 • 264 citations

ACTION OF THE NEUROTOXIN KAINIC ACID ON HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMIC ACID IN RAT BRAIN SLICES

1979 • 263 citations

Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids

1972 • 260 citations

Evaluation of glutamate as a neurotransmitter of cerebellar parallel fibers

1978 • 238 citations

Ca2+-dependent and Ca2+- independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: Possible relevance to hyoglycaemia and anoxia

1988 • 228 citations

Occurrence of a Large Ca²⁺‐Independent Release of Glutamate During Anoxia in Isolated Nerve Terminals (Synaptosomes)

1988 • 212 citations

Adenosine triphosphate-dependent uptake of glutamate into protein I-associated synaptic vesicles.

1983 • 206 citations

Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release.

1976 • 183 citations

Bioenergetics of neurotransmitter transport

1983 • 181 citations

RESPIRATION IN VITRO OF SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 181 citations

Non vesicular release of neurotransmitter.

1982 • 170 citations

The Ca²⁺/Cl⁻ dependent L‐[³H]glutamate binding: a new receptor or a particular transport process?

1984 • 169 citations

Exchange of neurotransmitter amino acid at nerve endings can simulate high affinity uptake

1974 • 168 citations

Mechanisms of secretion from adrenal chromaffin cells

1984 • 162 citations

Chemiluminescent determination of acetylcholine, and continuous detection of its release from torpedo electric organ synapses and synaptosomes

1981 • 152 citations

Synaptosomal bioenergetics

1986 • 149 citations

EFFECTS OF ELEVATED [K⁺]₀ ON THE RELEASE OF NEUROTRANSMITTERS FROM CORTICAL SYNAPTOSOMES: EFFLUX OR SECRETION?

1978 • 143 citations

AMINO ACIDS IN SYNAPTIC VESICLES FROM MAMMALIAN CEREBRAL CORTEX: A REAPPRAISAL

1973 • 142 citations

METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 142 citations

⁴⁵Ca²⁺ Uptake into Rat Whole Brain Synaptosomes Unaltered by Dihydropyridine Calcium Antagonists

1983 • 137 citations

Putative acidic amino acid transmitters in the cerebellum I. Depolarization-induced release

1982 • 137 citations

Characterization of the Exocytotic Release of Glutamate from Guinea‐Pig Cerebral Cortical Synaptosomes

1987 • 135 citations

Initial release of [3H]dopamine from rat striatal synaptosomes: correlation with calcium entry

1983 • 135 citations

Uptake of γ‐Aminobutyric Acid by a Synaptic Vesicle Fraction Isolated from Rat Brain

1988 • 134 citations

KINETICS OF THE SODIUM‐DEPENDENT TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES

1973 • 133 citations

Heterogeneity of sodium‐dependent excitatory amino uptake mechanisms in rat brain

1986 • 133 citations

Presynaptic calcium channels in rat cortical synaptosomes: fast- kinetics of phasic calcium influx, channel inactivation, and relationship to nitrendipine receptors

1986 • 116 citations

PATTERNS OF AMINO ACID RELEASE FROM NERVE-ENDINGS ISOLATED FROM SPINAL CORD AND MEDULLA

1973 • 114 citations

Regulation of cytosolic calcium concentration in presynaptic nerve endings isolated from rat brain.

1985 • 113 citations

Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates

1987 • 111 citations

ON THE SITE OF ORIGIN OF TRANSMITTER AMINO ACIDS RELEASED BY DEPOLARIZATION OF NERVE TERMINALS IN VITRO

1977 • 111 citations

The early time course of potassium‐stimulated calcium uptake in presynaptic nerve terminals isolated from rat brain.

1985 • 105 citations

Stimulus-Coupled Secretion of γ-Aminobutyric Acid from Rat Brain Synaptosomes

1973 • 103 citations

Studies on [3H] GABA and endogenous GABA release in rat cerebral cortex suggest the presence of autoreceptors of the GABAB type

1987 • 101 citations

Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential

1980 • 100 citations

Aspartate transport in synaptosomes from rat brain.

1983 • 99 citations

BAY K 8644, a 1,4‐Dihydropyridine Ca²⁺ Channel Activator: Dissociation of Binding and Functional Effects in Brain Synaptosomes

1984 • 99 citations

Influence of membrane potential on the sodium-dependent uptake of gamma-aminobutyric acid by presynaptic nerve terminals: Experimental observations and theoretical considerations

1976 • 98 citations

alpha-latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes.

1982 • 97 citations

A reevaluation of veratridine as a tool for studying the depolarization-induced release of neurotransmitters from nerve endings

1980 • 93 citations

Calcium Transport by Intact Synaptosomes

2005 • 91 citations

CALCIUM‐DEPENDENT RELEASE OF EXOGENOUSLY LOADED γ‐AMINO‐[U‐¹⁴C]BUTYRATE FROM SYNAPTOSOMES: TIME COURSE OF STIMULATION BY POTASSIUM, VERATRIDINE, AND THE CALCIUM IONOPHORE, A23187

1976 • 90 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Sodium‐Dependent Efflux of [³H]GABA from Synaptosomes Probably Related to Mitochondrial Calcium Mobilization

1980 • 87 citations

Inhibition by botulinum toxin of depolarization-evoked release of (14C)acetylcholine from synaptosomes in vitro

1976 • 85 citations

Relationships Among ATP Synthesis, K⁺ Gradients, and Neurotransmitter Amino Acid Levels in Isolated Rat Brain Synaptosomes

1987 • 82 citations

Botulinum toxin A blocks glutamate exocytosis from guinea-pig cerebral cortical synaptosomes

1987 • 81 citations

Evaluation of glutamate as a hippocampal neurotransmitter: Glutamate uptake and release from synaptosomes

1978 • 81 citations

A comparison of sodium-dependent glutamate binding with high-affinity glutamate uptake in rat striatum

1980 • 81 citations

Effects of Kainic Acid in Rat Brain Synaptosomes: The Involvement of Calcium

1984 • 80 citations

ON THE MECHANISM BY WHICH VERATRIDINE CAUSES A CALCIUM‐INDEPENDENT RELEASE OF γ‐AMINOBUTYRIC ACID FROM BRAIN SLICES

1981 • 80 citations

On the mechanism of acetylcholine release

1986 • 79 citations

Ca²⁺ Transport by Intact Synaptosomes: the Voltage‐Dependent Ca²⁺ Channel and a Re‐evaluation of the Role of Sodium/Calcium Exchange

1981 • 77 citations

Energetics of gamma-aminobutyrate transport in rat brain synaptosomes.

1982 • 74 citations

RELATIONSHIP BETWEEN Ca²⁺‐DEPENDENT AND INDEPENDENT RELEASE OF [³H]GABA EVOKED BY HIGH K⁺, VERATRIDINE OR ELECTRICAL STIMULATION FROM RAT CORTICAL SLICES

1979 • 74 citations

A Bioluminescence Method for the Measurement of l‐Glutamate: Applications to the Study of Changes in the Release of l‐Glutamate from Lateral Geniculate Nucleus and Superior Colliculus After Visual Cortex Ablation in Rats

1986 • 73 citations

Ionophore A23187, Verapamil, Protonophores, and Veratridine Influence the Release of γ‐Aminobutyric Acid from Synaptosomes by Modulation of the Plasma Membrane Potential Rather than the Cytosolic Calcium

1984 • 72 citations

Failure to Maintain Glycolysis in Anoxic Nerve Terminals

1986 • 71 citations

4‐Aminobutyrate Can Be Released Exocytotically from Guinea‐Pig Cerebral Cortical Synaptosomes

1987 • 70 citations

AMINO ACIDS AS PUTATIVE TRANSMITTERS: FAILURE TO BIND TO SYNAPTIC VESICLES OF GUINEA PIG CEREBRAL CORTEX¹

1972 • 69 citations

Kainic Acid Inhibits the Synaptosomal Plasma Membrane Glutamate Carrier and Allows Glutamate Leakage from the Cytoplasm but Does Not Affect Glutamate Exocytosis

1988 • 66 citations

Characteristics of chloride-dependent incorporation of glutamate into brain membranes argue against a receptor binding site

1987 • 60 citations

Glutamate Release from Guinea‐Pig Synaptosomes: Stimulation by Reuptake‐Induced Depolarization

1989 • 59 citations

Kainic Acid Differentially Affects the Synaptosomal Release of Endogenous and Exogenous Amino Acidic Neurotransmitters

1985 • 59 citations

Ammonia‐Induced Release of Neurotransmitters from Rat Brain Synaptosomes: Differences Between the Effects on Amines and Amino Acids

1987 • 58 citations

Glutamate as a Putative Transmitter in the Cerebellum: Stimulation by GABA of Glutamic Acid Release from Specific Pools

1981 • 58 citations

Changes in the Relative Amounts of Aspartate and Glutamate Released and Retained in Hippocampal Slices During Stimulation

1988 • 55 citations

Relation of Acetylcholine Release to Ca²⁺ Uptake and Intraterminal Ca²⁺ Concentration in Guinea‐Pig Cortex Synaptosomes

1987 • 54 citations

Modulation of γ-aminobutyric acid transport in nerve endings: Role of extracellular γ-aminobutyric acid and of cationic fluxes

1978 • 54 citations

Evidence for GABAB autoreceptors in median eminence

1985 • 53 citations

Botulinum toxin types A, B and D inhibit catecholamine secretion from bovine adrenal medullary cells

1986 • 53 citations

Na⁺‐Dependent “Binding” of D‐Aspartate in Brain Membranes Is Largely Due to Uptake into Membrane‐Bounded Saccules

1986 • 52 citations

Phorbol ester translocation of protein kinase C in guinea-pig synaptosomes and the potentiation of calcium-dependent glutamate release

1988 • 52 citations

NET UPTAKE OF L‐GLUTAMATE AND GABA BY HIGH AFFINITY SYNAPTOSOMAL TRANSPORT SYSTEMS

1978 • 48 citations

Changes in free-calcium levels and pH in synaptosomes during transmitter release

1984 • 44 citations

Selective release of newly synthesised and newly captured GABA from synaptosomes by potassium depolarisation

1975 • 41 citations

Studies on synaptic vesicles in mammalian brain characterization of highly purified synaptic vesicles from bovine cerebral cortex

1979 • 40 citations

Effects of Ca²⁺ Channel Blockers on Ca²⁺ Translocation Across Synaptosomal Membranes

1986 • 40 citations

Glutamate, aspartate, and γ-aminobutyrate transport by membrane vesicles prepared from rat brain

1981 • 38 citations

γ-Aminobutyric acid release from synaptosomes as influenced by Ca2+ and Ca2+ channel blockers

1986 • 36 citations

Dependence of cytoplasmic calcium transients on the membrane potential in isolated nerve endings of the guinea pig

1985 • 36 citations

Release and exchange of neurotransmitters in synaptosomes: Effects of the ionophore A23187 and of ouabain

1976 • 36 citations

Studies on the relationship between Ca2+ efflux from mitochondria and the release of amino acid neurotransmitters

1980 • 35 citations

Calcium efflux and cycling across the synaptosomal plasma membrane

1985 • 34 citations

Release studies related to the neurotransmitter role of glutamate in the cerebellum: An overview

1986 • 34 citations

Effects of L-glutamic acid on synaptosomal and synaptic membrane Na+ fluxes and (Na+-K+)-ATPase.

1980 • 33 citations

Acetylcholine quanta are released from vesicles by exocytosis (and why some think not)

1988 • 33 citations

A novel superfusion chamber for the measurement of endogenous glutamate release from cerebellar slices

1988 • 32 citations

The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels

1986 • 31 citations

Presence of Radiolabelled Metabolites in Release Studies Using [3H]?-Aminobutyric Acid

1981 • 27 citations

THE INFLUENCE OF SODIUM, POTASSIUM AND LANTHANUM ON AMINO ACID RELEASE FROM SPINAL–MEDULLARY SYNAPTOSOMES

1975 • 26 citations

External calcium, intrasynaptosomal free calcium and neurotransmitter release

1986 • 24 citations

Depolarization of the mitochondrial membrane potential increases free cytosolic calcium in synaptosomes

1984 • 23 citations

On the Metabolic and Intrasynaptic Origin of Amino Acid Transmitters

1978 • 21 citations

Net uptake of gamma-aminobutyric acid by a high-affinity system of rat brain synaptosomes.

1981 • 21 citations

l-Glutamate effects on electrical potentials of synaptic plasma membrane vesicles

1982 • 20 citations

L-glutamate stimulation of Na+ efflux from brain synaptic membrane vesicles.

1981 • 20 citations

Synthesis and Release of Amino Acid Transmitters

1986 • 20 citations

Patch-clamp recording from single glutamate-receptor channels

1987 • 20 citations

Studies on the release of exogenous and endogenous GABA and glutamate from rat brain synaptosomes

1981 • 19 citations

Mechanism of depolarization of rat cortical synaptosomes at submicromolar external Ca2+ activity. The use of Ca2+ buffers to control the synaptosomal membrane potential

1985 • 18 citations

Protein kinase C in the nervous system of insects: effects of phorbol esters on cholinergic synapses

1987 • 17 citations

Kinetics ofd-aspartic acid release from rat cortical synaptosomes

1984 • 17 citations

Synaptic vesicles from hog brain—their isolation and the coupling between synthesis and uptake of γ-aminobutyrate by glutamate decarboxylase

1983 • 17 citations

A kinetic analysis of the release of acidic amino acids from rat cortical synaptosomes following pre-loading with [14C]glutamic acid

1983 • 16 citations

ON THE FUNCTIONAL COUPLING OF NEUROTRANSMITTER UPTAKE AND RELEASE IN BRAIN

1976 • 14 citations

Quantal currents evoked by graded intracellular depolarization of crayfish motor axon terminals.

1987 • 14 citations

Compartmentation of Ca2+ -dependent pools of glutamate and aspartate in isolated cerebral cortical nerve terminals by isotopic exchange and fractionation

1988 • 12 citations

Substrate specificity and developmental aspects of a presynaptic gaba receptor regulating glutamate release in the rat cerebellum

1983 • 12 citations

The content of GABA and other amino acids in bovine cerebral cortex synaptic vesicles

1978 • 9 citations

On the Role of Mitochondria in Neurotransmitter Release

1981 • 9 citations

Presynaptic regulation of glutamate release from guinea-pig cortical synaptosomes

1988 • 9 citations

Depolarization-induced release of l-glutamic acid from isolated-resealed synaptic membrane vesicles

1984 • 7 citations