Genetic and biochemical analysis of vesicular traffic in yeast

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway

1990 • 721 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

1991 • 604 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast

1990 • 578 citations

A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast

1989 • 570 citations

ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway

1990 • 548 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

An essential role for a phospholipid transfer protein in yeast Golgi function

1990 • 534 citations

Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport.

1988 • 519 citations

Involvement of GTP-binding “G” proteins in transport through the Golgi stack

1987 • 495 citations

A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus.

1989 • 443 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.

1990 • 372 citations

Binding of ARF and β-COP to Golgi Membranes: Possible Regulation by a Trimeric G Protein

1991 • 359 citations

Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

1991 • 359 citations

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein

1991 • 348 citations

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.

1991 • 347 citations

Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles.

1991 • 318 citations

Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic.

1989 • 314 citations

The signal recognition particle in S. cerevisiae

1991 • 299 citations

Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein

1989 • 288 citations

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast.

1988 • 275 citations

A multisubunit particle implicated in membrane fusion.

1992 • 271 citations

Dissection of a single round of vesicular transport: Sequential intermediates for intercisternal movement in the Golgi stack

1989 • 269 citations

Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae.

1991 • 268 citations

Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

1989 • 258 citations

Vesicle fusion following receptor-mediated endocytosis requires a protein active in Golgi transport

1989 • 250 citations

Functional compartments of the yeast Golgi apparatus are defined by the sec7 mutation.

1989 • 249 citations

Localization of components involved in protein transport and processing through the yeast Golgi apparatus.

1991 • 247 citations

Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calcium

1988 • 243 citations

The ERD2 gene determines the specificity of the luminal ER protein retention system

1990 • 243 citations

The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants.

1989 • 234 citations

Requirement of GTP Hydrolysis for Dissociation of the Signal Recognition Particle from Its Receptor

1991 • 222 citations

The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport.

1991 • 193 citations

SEC11 is required for signal peptide processing and yeast cell growth.

1988 • 185 citations

GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.

1990 • 177 citations

The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein.

1992 • 159 citations

Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein

1989 • 154 citations

Nucleotide binding and cofactor activities of purified bovine brain and bacterially expressed ADP-ribosylation factor

1989 • 150 citations

Sec12p-dependent membrane binding of the small GTP-binding protein Sar1p promotes formation of transport vesicles from the ER.

1991 • 143 citations

A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein.

1988 • 138 citations

Synthetic peptides of the Rab effector domain inhibit vesicular transport through the secretory pathway.

1990 • 134 citations

Yeast Sec23p acts in the cytoplasm to promote protein transport from the endoplasmic reticulum to the Golgi complex in vivo and in vitro.

1989 • 128 citations

Sec23p and a novel 105-kDa protein function as a multimeric complex to promote vesicle budding and protein transport from the endoplasmic reticulum.

1992 • 126 citations

Dependence of Ypt1 and Sec4 membrane attachment on Bet2

1991 • 118 citations

Trimeric G‐proteins of the trans‐Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules

1991 • 117 citations

Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.

1991 • 92 citations

Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport.

1991 • 84 citations

A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein.

1991 • 78 citations

Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum.

1991 • 76 citations

Yeast signal peptidase contains a glycoprotein and the Sec11 gene product.

1991 • 72 citations

Immuno-isolation of Sec7p-coated transport vesicles from the yeast secretory pathway

1992 • 63 citations

Co‐operative binding of hsp60 may promote transfer hsp70 and correct folding of imported proteins in mitochondria

1991 • 19 citations