Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

2002 • 10,002 citations

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

1997 • 6,073 citations

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

2001 • 1,477 citations

Prediction of Type I Diabetes in First-Degree Relatives Using a Combination of Insulin, GAD, and ICA512bdc/IA-2 Autoantibodies

1996 • 788 citations

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

1999 • 633 citations

EVIDENCE FOR A LONG PREDIABETIC PERIOD IN TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS

1981 • 480 citations

Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives

1994 • 360 citations

Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes

1990 • 356 citations

Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation

2003 • 355 citations

Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.

1998 • 283 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

First-Degree Relatives of Patients with Type I Diabetes Mellitus

1985 • 226 citations

Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.

1994 • 184 citations

Successful Prospective Prediction of Type 1 Diabetes in Schoolchildren Through Multiple Defined Autoantibodies

2002 • 174 citations

Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome.

1993 • 162 citations

Natural History of β-Cell Autoimmunity in Young Children with Increased Genetic Susceptibility to Type 1 Diabetes Recruited from the General Population

2002 • 147 citations

Life-Table Analysis of Progression to Diabetes of Anti-Insulin Autoantibody-Positive Relatives of Individuals With Type I Diabetes

1989 • 141 citations

Antibodies to Islet 37k Antigen, But Not to Glutamate Decarboxylase, Discriminate Rapid Progression to IDDM in Endocrine Autoimmunity

1994 • 134 citations

Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-Specific Regulation

1999 • 131 citations

Autoantibody Response to Islet Transplantation in Type 1 Diabetes

2001 • 126 citations

Interactions of Age, Islet Cell Antibodies, Insulin Autoantibodies, and First-Phase Insulin Response in Predicting Risk of Progression to IDDM in ICA+ Relatives: The ICARUS Data Set

1996 • 122 citations

Screening Strategies for the Identification of Multiple Antibody-Positive Relatives of Individuals with Type 1 Diabetes

2003 • 122 citations

Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives

1994 • 114 citations

Only Multiple Autoantibodies to Islet Cells (ICA), Insulin, GAD65, IA-2 and IA-2β Predict Immune-Mediated (Type 1) Diabetes in Relatives

1999 • 112 citations

Early Development and Spreading of Autoantibodies to Epitopes of IA-2 and Their Association with Progression to Type 1 Diabetes

1998 • 100 citations

Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes.

2000 • 100 citations

IA-2 autoantibodies predict impending Type I diabetes in siblings of patients

2002 • 91 citations

Immune reactivity to glutamic acid decarboxylase 65 in stiff-man syndrome and type 1 diabetes mellitus

2000 • 90 citations

IgE and IgG subclass regulation by IL-4 and IFN-gamma in human helminth infections. Assessment by B cell precursor frequencies.

1993 • 84 citations

IA-2 (Islet Cell Antigen 512) Is the Primary Target of Humoral Autoimmunity Against Type 1 Diabetes-Associated Tyrosine Phosphatase Autoantigens

1998 • 79 citations

Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality.

2000 • 78 citations

Autoantibody Recognition of COOH-Terminal Epitopes of GAD65 Marks the Risk for Insulin Requirement in Adult-Onset Diabetes Mellitus¹

2000 • 78 citations

Progression to diabetes in relatives with islet autoantibodies. Is it inevitable?

1999 • 73 citations

Proposed Guidelines on Screening for Risk of Type 1 Diabetes

2001 • 73 citations

GADIA2-combi determination as first-line screening for improved prediction of type 1 diabetes in relatives.

1998 • 64 citations

Life-table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with type I diabetes

1989 • 61 citations

Autoantibody Recognition of COOH-Terminal Epitopes of GAD65 Marks the Risk for Insulin Requirement in Adult-Onset Diabetes Mellitus

2000 • 52 citations

Prevalence, Characteristics and Diabetes Risk Associated with Transient Maternally Acquired Islet Antibodies and Persistent Islet Antibodies in Offspring of Parents with Type 1 Diabetes

2001 • 46 citations

Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA+ relatives: the ICARUS data set. Islet Cell Antibody Register Users Study

1996 • 44 citations

Immunoglobulin G Insulin Autoantibodies in BABYDIAB Offspring Appear Postnatally: Sensitive Early Detection Using a Protein A/G-Based Radiobinding Assay¹

1999 • 43 citations

Antibodies to islet 37k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity

1994 • 41 citations

IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes

1998 • 38 citations

Progression to Type 1 Diabetes Is Associated with a Change in the Immunoglobulin Isotype Profile of Autoantibodies to Glutamic Acid Decarboxylase (GAD65)

1999 • 35 citations

Immunoglobulin G Insulin Autoantibodies in BABYDIAB Offspring Appear Postnatally: Sensitive Early Detection Using a Protein A/G-Based Radiobinding Assay

1999 • 30 citations

IA-2 Autoantibodies Restricted to the IgG4 Subclass are Associated with Protection from Type 1 Diabetes

2002 • 15 citations

ICA512(IA-2) Epitope Specific Assays Distinguish Transient from Diabetes Associated Autoantibodies

2002 • 11 citations