NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

The Myofibroblast

2007 • 1,901 citations

How cells read TGF-β signals

2000 • 1,843 citations

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

1998 • 801 citations

international consensus statement

2000 • 794 citations

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

2009 • 777 citations

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

2005 • 739 citations

NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

2007 • 591 citations

Direct Interaction of the Novel Nox Proteins with p22phox Is Required for the Formation of a Functionally Active NADPH Oxidase

2004 • 526 citations

Role of Reactive Oxygen Species in TGF-β1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells

2005 • 506 citations

Oxidative Stress in Pulmonary Fibrosis

2005 • 410 citations

The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis.

1991 • 406 citations

Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

2005 • 387 citations

TGF-β1-mediated fibroblast–myofibroblast terminal differentiation—the role of smad proteins

2003 • 360 citations

Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression

2001 • 348 citations

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

1996 • 326 citations

Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature

2007 • 321 citations

Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?

2007 • 318 citations

Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation

2005 • 224 citations

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

2008 • 183 citations

Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells

2005 • 160 citations

Nox1 Mediates Basic Fibroblast Growth Factor-Induced Migration of Vascular Smooth Muscle Cells

2007 • 143 citations

Nox4 mediates TGF-β1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells

2007 • 128 citations

NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts

2008 • 124 citations

The Myofibroblast: one function, multiple origins

2010 • 120 citations

Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism

2007 • 91 citations

Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25-T cells

2007 • 85 citations

Defect of Hepatocyte Growth Factor Secretion by Fibroblasts in Idiopathic Pulmonary Fibrosis

2003 • 70 citations

Tobacco smoke extract induces age‐related changes due to modulation of TGF‐β

2003 • 59 citations

In situ hybridization analysis of rat lung alpha 1(I) and alpha 2(I) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection.

1994 • 55 citations

Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance

2009 • 48 citations

Clinical review: Idiopathic pulmonary fibrosis—Past, present and future

2006 • 47 citations

Tumor Necrosis Factor-α Increases Airway Smooth Muscle Oxidants Production through a NADPH Oxidase-like System to Enhance Myosin Light Chain Phosphorylation and Contractility

2002 • 43 citations

The use of diphenylene iodonium and its analogues to investigate the role of the nadph oxidase in the tumoricidal activity of macrophages in vitro

1991 • 24 citations