Stepwise activation of the immunoglobulin micro heavy chain gene locus

The language of covalent histone modifications

2000 • 8,260 citations

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1998 • 3,363 citations

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1998 • 2,686 citations

Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

1999 • 1,774 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

DNA methylation and chromatin modification

1999 • 641 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

2001 • 362 citations

Review: Chromatin Structural Features and Targets That Regulate Transcription

2000 • 348 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro

1996 • 305 citations

ACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements

1996 • 295 citations

A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

2000 • 286 citations

Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell Receptor

1997 • 253 citations

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

1999 • 251 citations

Analysis of the B-cell progenitor compartment at the level of single cells

1994 • 232 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Function of the TCRα Enhancer in αβ and γδ T Cells

1997 • 204 citations

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

1990 • 203 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

DNA methylation: A molecular lock

1997 • 179 citations

Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development

2000 • 161 citations

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

2000 • 158 citations

Control of V(D)J Recombinational Accessibility of the Dβ1 Gene Segment at the TCRβ Locus by a Germline Promoter

1999 • 145 citations

Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression

1998 • 138 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

Role of interleukin‐7 in T‐cell development from hematopoietic stem cells

1998 • 130 citations

Stimulation of V(D)J recombination by histone acetylation

2000 • 121 citations

The Interleukin 7 Receptor Is Required for T Cell Receptor γ Locus Accessibility to the V(D)j Recombinase

2000 • 103 citations

Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions

1999 • 97 citations

Deletion of Germline Promoter PDβ1 from the TCRβ Locus Causes Hypermethylation that Impairs Dβ1 Recombination by Multiple Mechanisms

2000 • 89 citations

Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene.

1994 • 85 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

Evidence that Immunoglobulin V_H-DJ Recombination Does Not Require Germ Line Transcription of the Recombining Variable Gene Segment

1998 • 81 citations

Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression.

1996 • 80 citations

Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation.

1991 • 77 citations

Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL- 7 receptor-deficient mice but can enhance survival of mature B cells

1998 • 70 citations

Nuclease Hypersensitive Sites In Chromatin

1988 • 69 citations

Murine Pro-B Cells Require IL-7 and Its Receptor Complex to Up-Regulate IL-7Rα, Terminal Deoxynucleotidyltransferase, and cμ Expression

2000 • 69 citations

Enhancer Control of Local Accessibility to V(D)J Recombinase

1997 • 68 citations

Functional GATA-3 binding sites within murine CD8 alpha upstream regulatory sequences.

1993 • 56 citations

VH gene family repertoire of resting B cells. Preferential use of D-proximal families early in development may be due to distinct B cell subsets.

1989 • 51 citations

A second promoter and enhancer element within the immunoglobulin heavy chain locus

1994 • 50 citations

Accessibility control of variable region gene assembly during T‐cell development

1998 • 48 citations

Definition of a T-Cell Receptor β Gene Core Enhancer of V(D)J Recombination by Transgenic Mapping

2000 • 44 citations

IL-7 Reconstitutes Multiple Aspects of v-Abl-Mediated Signaling

1998 • 35 citations

Accessibility changes across the mouse Igh-V locus during B cell development

1998 • 32 citations

Regulation of expression of T cell γ chain, L3T4 and Ly-2 messages in Abelson/moloney virus-transformed T cell lines

1988 • 30 citations

A V(D)J Recombinase-Inducible B-Cell Line: Role of Transcriptional Enhancer Elements in Directing V(D)J Recombination

1993 • 29 citations

Coordination of Immunoglobulin DJ_H Transcription and D-to-J_H Rearrangement by Promoter-Enhancer Approximation

1991 • 26 citations

A survey of protein‐DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ₅₂ element

1992 • 24 citations

Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate

1994 • 20 citations

Differential Usage of VH Gene Segments Is Mediated bycisElements

1998 • 18 citations

Accessibility changes across the mouse Igh-V locus during B cell development

1998 • 1 citations