A survey of protein‐DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ₅₂ element

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1981 • 959 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.

1988 • 670 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.

1988 • 429 citations

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1987 • 346 citations

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

1986 • 344 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult β-globin gene: Nature of the binding domain

1985 • 255 citations

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

1987 • 229 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining

1987 • 222 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

1986 • 186 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

1988 • 177 citations

Effects of tRNATyr point mutations on the binding of yeast RNA polymerase III transcription factor C.

1986 • 147 citations

T cell receptor β gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining

1987 • 144 citations

A sensitive and rapid gel retention assay for nuclear factor I and other DNA-binding proteins in crude nuclear extracts

1986 • 143 citations

Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo.

1988 • 119 citations

A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer.

1989 • 116 citations

Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.

1983 • 113 citations

Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

1987 • 113 citations

Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development.

1980 • 89 citations

Coordination of immunoglobulin DJH transcription and D-to-JH rearrangement by promoter-enhancer approximation.

1991 • 77 citations

Rearrangement of IgH genes in normal thymocyte development.

1988 • 71 citations

DNA-binding properties and characterization of human transcription factor TFIIIC2.

1987 • 70 citations

Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.

1989 • 67 citations

Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.

1991 • 65 citations

The Immunoglobulin Heavy-Chain Enhancer Functions as the Promoter for Iμ Sterile Transcription

1990 • 61 citations

Rearrangement of immunoglobulin heavy chain genes in human T leukaemic cells shows preferential utilization of the D segment (DQ52) nearest to the J region.

1986 • 57 citations

Estimation of D segment usage in initial D to JH joinings in a murine immature B cell line. Preferential usage of DFL16.1, the most 5' D segment and DQ52, the most JH-proximal D segment.

1990 • 46 citations

T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line

1989 • 37 citations

The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription.

1990 • 33 citations

Insertion of L1 elements into sites that can form non-B DNA

1989 • 24 citations

Lineage-specific expression of a T cell receptor variable gene promoter controlled by upstream sequences.

1989 • 22 citations

Rearrangement of exogenous immunoglobulin VH and DJH gene segments after retroviral transduction into immature lymphoid cell lines.

1988 • 15 citations

The tetrameric structure of NF-mu NR provides a mechanism for cooperative binding to the immunoglobulin heavy chain mu enhancer.

1992 • 12 citations

Chapter 4 Assembly of immunoglobulin variable region gene segments

1987 • 9 citations

DNA bending induced by specific interaction of decamer binding proteins with immunoglobulin gene control sequences

1988 • 3 citations