Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

Somatic generation of antibody diversity

1983 • 3,275 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.

1983 • 810 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Evidence of functional lymphocytes in some (leaky) scid mice.

1988 • 347 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

GENETICS OF A NEW IgVH (T15 IDIOTYPE) MARKER IN THE MOUSE REGULATING NATURAL ANTIBODY TO PHOSPHORYLCHOLINE

1974 • 247 citations

Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines

1982 • 228 citations

Population Dynamics of Bone Marrow B Lymphocytes

1986 • 210 citations

VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

1986 • 186 citations

Developmentally regulated and strain-specific expression of murine VH gene families.

1988 • 186 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

1985 • 147 citations

Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.

1988 • 141 citations

Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c mice

1986 • 139 citations

One heavy chain variable region gene segment subfamily in the BALBc mouse contains 500–1000 or more members

1986 • 132 citations

Antibody Repertoires of Normal BALB/c Mice: B Lymphocyte Populations Defined by State of Activation

1986 • 129 citations

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

1986 • 127 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.

1975 • 117 citations

The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.

1988 • 116 citations

Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

1982 • 107 citations

During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation

1986 • 105 citations

Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression.

1988 • 104 citations

An immunofluorescence analysis of the ontogeny of myeloid, T, and B lineage cells in mouse hemopoietic tissues.

1984 • 104 citations

Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

1987 • 100 citations

A MEMBER OF A NEW V_H GENE FAMILY ENCODES ANTI‐BROMELINIZED MOUSE RED BLOOD CELL AUTOANTIBODIES

1988 • 92 citations

Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development.

1980 • 89 citations

High connectivity, natural antibodies preferentially use 7183 and QUPC52 V_H families

1987 • 88 citations

The mechanism of thymus-dependent antibody formation in bone marrow.

1981 • 81 citations

Late acquisition of a germ line antibody specificity

1976 • 81 citations

A new murine Ig VH gene family.

1988 • 75 citations

Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.

1987 • 72 citations

Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

1981 • 69 citations

Specificities and V genes encoding monoclonal autoantibodies from viable motheaten mice.

1988 • 66 citations

Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.

1979 • 64 citations

Characterization of Productive and Sterile Transcripts from the Immunoglobulin Heavy-Chain Locus: Processing of μ_m and μ_s mRNA

1983 • 63 citations

Immunological unresponsiveness to native dextran B512 in young animals of dextran high responder strains is due to lack of Ig receptors expression. Evidence for a nonrandom expression of V-genes.

1978 • 62 citations

Murine V kappa gene expression does not follow the VH paradigm.

1989 • 61 citations

Induction of Antibody Formation In Mouse Bone Marrow

1981 • 60 citations

Organization of the murine immunoglobulin VH complex in the inbred strains.

1987 • 59 citations

Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny.

1979 • 55 citations

Strain-dependent expression of VH gene families.

1988 • 53 citations

Immunoglobulin V_H region genes of the mouse are organized in overlapping clusters

1987 • 51 citations

Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes.

1986 • 47 citations

Organization of genes and spacers within the mouse immunoglobulin VH locus.

1981 • 46 citations

Ontogeny of B cell precursors responding to alpha 1- greater than 3 dextran in BALB/c mice.

1984 • 44 citations

VH gene family utilization is regulated by a locus outside of the VH region.

1988 • 36 citations

Isotype, VH genes, and antigen-binding analysis of hybridomas from newborn normal BALB/c mice.

1988 • 36 citations

Genetic and temporal control of neonatal antibody expression.

1983 • 36 citations

The Ontogeny and Organization of the Lymphoid System

1985 • 36 citations

Late clonal selection and expansion of the TEPC-15 germ-line specificity.

1980 • 34 citations

Highly preferential VH-VL pairing in normal B cells results in antigen-independent selection of the available repertoire.

1987 • 30 citations

B cell immune repertoire diversifies in a predictable temporal order in vitro.

1985 • 26 citations

Selective use of the VHQ52 family in functional VH to DJH rearrangements in a B precursor cell line.

1987 • 23 citations

Changes in B lineage cell population in liver and spleen of normal neonatal mice.

1983 • 15 citations

Ig gene rearrangement and expression in the progeny of B-cell progenitors in the course of clonal expansion in bone marrow cultures.

1987 • 14 citations

Patterns of Ig V region expression among neonatal hemagglutinin-responsive B cells. Evidence for non-random VH gene representation during later stages of development.

1988 • 9 citations

The Effect of the scid Mutation on Mechanism and Control of Immunoglobulin Heavy and Light Chain Gene Rearrangement

1989 • 7 citations