Insights into host responses against pathogens from transcriptional profiling

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 • 3,507 citations

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

2001 • 2,152 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

Genome-Wide Location and Function of DNA Binding Proteins

2000 • 1,720 citations

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

2000 • 1,644 citations

Inferences, questions and possibilities in Toll-like receptor signalling

2004 • 1,458 citations

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages

2003 • 1,374 citations

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

2004 • 1,293 citations

Severe CD4⁺T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

2003 • 858 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages

2002 • 802 citations

The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

2001 • 760 citations

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

2003 • 709 citations

Human macrophage activation programs induced by bacterial pathogens

2002 • 697 citations

Toll-like receptors: key mediators of microbe detection

2002 • 689 citations

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

2003 • 660 citations

The damage-response framework of microbial pathogenesis

2003 • 574 citations

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.

2001 • 544 citations

Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection

2003 • 516 citations

The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

2002 • 481 citations

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

2001 • 458 citations

Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma

2004 • 457 citations

Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays

1998 • 445 citations

DNA Microarray Analysis of Chimpanzee Liver during Acute Resolving Hepatitis C Virus Infection

2001 • 442 citations

Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus

2003 • 418 citations

Stereotyped and specific gene expression programs in human innate immune responses to bacteria

2002 • 396 citations

Papillomavirus Type 16 Oncogenes Downregulate Expression of Interferon-Responsive Genes and Upregulate Proliferation-Associated and NF-κB-Responsive Genes in Cervical Keratinocytes

2001 • 374 citations

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus

2004 • 371 citations

Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza

2002 • 370 citations

Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver

2001 • 354 citations

Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock

2004 • 346 citations

Bacterial pathogens modulate an apoptosis differentiation program in human neutrophils

2003 • 333 citations

Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

2003 • 311 citations

Microarray Analysis Identifies Interferon-Inducible Genes and Stat-1 as Major Transcriptional Targets of Human Papillomavirus Type 31

2000 • 285 citations

Altered Cellular mRNA Levels in Human Cytomegalovirus-Infected Fibroblasts: Viral Block to the Accumulation of Antiviral mRNAs

2001 • 273 citations

Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts

2003 • 270 citations

Nef Triggers a Transcriptional Program in T Cells Imitating Single-Signal T Cell Activation and Inducing HIV Virulence Mediators

2001 • 269 citations

Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

2001 • 263 citations

Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method.

2002 • 246 citations

Elevated Levels of Interleukin-8 in Serum Are Associated with Hepatitis C Virus Infection and Resistance to Interferon Therapy

2001 • 242 citations

Flagellin Is the Major Proinflammatory Determinant of Enteropathogenic Salmonella

2003 • 229 citations

Molecular Characterization of the Acute Inflammatory Response to Infections with Gram-Negative versus Gram-Positive Bacteria

2003 • 225 citations

HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages

2003 • 219 citations

Expression of Respiratory Syncytial Virus-Induced Chemokine Gene Networks in Lower Airway Epithelial Cells Revealed by cDNA Microarrays

2001 • 215 citations

A Comprehensive View of Regulation of Gene Expression by Double-stranded RNA-mediated Cell Signaling

2001 • 212 citations

Salmonella typhimuriumInfection and Lipopolysaccharide Stimulation Induce Similar Changes in Macrophage Gene Expression

2000 • 212 citations

Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection

2002 • 207 citations

Global modulation of cellular transcription by human cytomegalovirus is initiated by viral glycoprotein B

2001 • 206 citations

Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile

2003 • 203 citations

Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses

2002 • 199 citations

The interferon in TLR signaling: more than just antiviral

2003 • 195 citations

Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells

2003 • 192 citations

Interaction of Pseudomonas aeruginosa with epithelial cells: Identification of differentially regulated genes by expression microarray analysis of human cDNAs

2000 • 179 citations

Gene expression and viral prodution in latently infected, resting CD4 ⁺ T cells in viremic versus aviremic HIV-infected individuals

2003 • 176 citations

Cellular Gene Expression upon Human Immunodeficiency Virus Type 1 Infection of CD4⁺-T-Cell Lines

2002 • 176 citations

Induction of Pathogenic Sets of Genes in Macrophages and Neurons in NeuroAIDS

2003 • 167 citations

The transcriptional responses of respiratory epithelial cells toBordetella pertussisreveal host defensive and pathogen counter-defensive strategies

2000 • 154 citations

Dengue Virus Induces Novel Changes in Gene Expression of Human Umbilical Vein Endothelial Cells

2003 • 148 citations

Kaposi's Sarcoma-Associated Herpesvirus-Induced Upregulation of the c-kitProto-Oncogene, as Identified by Gene Expression Profiling, Is Essential for the Transformation of Endothelial Cells

2002 • 145 citations

Maturation of Human Monocyte-Derived Dendritic Cells Studied by Microarray Hybridization

2000 • 144 citations

Identification of NF-κB-Dependent Gene Networks in Respiratory Syncytial Virus-Infected Cells

2002 • 135 citations

Cellular Gene Expression Survey of Vaccinia Virus Infection of Human HeLa Cells

2003 • 124 citations

Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death

2001 • 124 citations

Identification of a TLR4‐ and TRIF‐dependent activation program of dendritic cells

2004 • 123 citations

Human Cytomegalovirus Elicits a Coordinated Cellular Antiviral Response via Envelope Glycoprotein B

2004 • 116 citations

Gene Expression Profiling of the Cellular Transcriptional Network Regulated by Alpha/Beta Interferon and Its Partial Attenuation by the Hepatitis C Virus Nonstructural 5A Protein

2003 • 114 citations

Host Gene Regulation During Coxsackievirus B3 Infection in Mice

2000 • 111 citations

Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter- induced mucosa-associated lymphoid tissue lymphoma

2003 • 108 citations

Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells

2003 • 105 citations

Temporal Gene Regulation During HIV-1 Infection of Human CD4⁺T Cells

2001 • 102 citations

Cumulative Toll-Like Receptor Activation in Human Macrophages Treated with Whole Bacteria

2003 • 100 citations

Distinctive gene expression profiles associated with Hepatitis B virus x protein

2001 • 97 citations

Identification of Genes Involved in the Host Response to Neurovirulent Alphavirus Infection

2001 • 96 citations

Microarray Analysis Reveals Characteristic Changes of Host Cell Gene Expression in Response to Attenuated Modified Vaccinia Virus Ankara Infection of Human HeLa Cells

2004 • 84 citations

Gene Expression Pattern in Caco-2 Cells following Rotavirus Infection

2002 • 84 citations

Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells

2003 • 82 citations

Temporal Gene Regulation During HIV-1 Infection of Human CD4+ T Cells

2001 • 79 citations

Pneumolysin-Dependent and -Independent Gene Expression Identified by cDNA Microarray Analysis of THP-1 Human Mononuclear Cells Stimulated byStreptococcus pneumoniae

2003 • 78 citations

Novel Program of Macrophage Gene Expression Induced by Phagocytosis ofLeishmania chagasi

2004 • 78 citations

Regulation of mRNA Expression in Macrophages afterYersinia enterocolitica Infection

2002 • 73 citations

An Altered Cellular Response to Interferon and Up-Regulation of Interleukin-8 Induced by the Hepatitis C Viral Protein NS5A Uncovered by Microarray Analysis

2002 • 71 citations

JC Virus-Induced Changes in Cellular Gene Expression in Primary Human Astrocytes

2003 • 70 citations

High-throughput gene expression profiling indicates dysregulation of intestinal cell cycle mediators and growth factors during primary simian immunodeficiency virus infection

2003 • 69 citations

Microarray Analysis of Host Cell Gene Transcription in Response to Varicella-Zoster Virus Infection of Human T Cells and Fibroblasts In Vitro and SCIDhu Skin Xenografts In Vivo

2002 • 69 citations

Latent Herpes Simplex Virus Infection of Sensory Neurons Alters Neuronal Gene Expression

2003 • 64 citations

Protective immunity against Helicobacter is characterized by a unique transcriptional signature

2003 • 63 citations

Differential Expression of Proinflammatory Cytokine Genes In Vivo in Response to Pathogenic and Nonpathogenic Pneumovirus Infections

2002 • 61 citations

Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV‐encephalitis

2003 • 53 citations

Gene expression patterns of epithelial cells modulated by pathogenicity factors ofYersinia enterocolitica

2004 • 52 citations

A Role for Toll-Like Receptor 4 in Dendritic Cell Activation and Cytolytic CD8+ T Cell Differentiation in Response to a Recombinant Heat Shock Fusion Protein

2004 • 46 citations